Navigation Links
Innate immune system targets asthma-linked fungus for destruction
Date:9/2/2008

luorescence microscopy to determine the outcome of the interaction between eosinophils and A. alternata. The contact of fungus with eosinophils resulted in bright red fluorescence due to the damaged fungal cell wall and subsequent death of Alternaria. Immunohistochemistry confirmed the release of toxic granular proteins by eosinophils due to contact with the fungus.

Dr. Chris Lawrence, Associate Professor at VBI and the Department of Biological Sciences at Virginia Tech, remarked: "T helper 2 (Th2) cells in the immune system typically produce cytokine signaling molecules or interleukins that lead to the recruitment of eosinophils for the dysregulated immune response commonly associated with airway inflammatory disorders. Continual exposure of sensitized individuals to common environmental fungi like Alternaria may result in Th2 cells being constantly activated to recruit eosinophils and this sustained defense mechanism results in chronic inflammation. It has been shown previously that degranulation of eosinophils causes damage of airway mucosa and enhances inflammation. The next step in our transdisciplinary research collaboration will be to use recombinant fungal proteins and fungal knockout mutants for specific genes to dissect the different molecular steps involved in the development and progression of this acute immune response."

Hirohito Kita added: "We have taken an important step in showing that the innate immune system of eosinophils is capable of targeting an asthma-associated fungus for destruction. The biological significance of these results will need to be verified further in animal models and in humans and our collaborative efforts with Dr. Lawrence's research group for proteomics and functional genomics will be invaluable in this respect. We suspect that the dysregulated immune responses to Alternaria, other filamentous fungi, and perhaps chitin-encased insects, such as mites and cockroaches, may play a pivotal role in chron
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Protein that provides innate defense against HIV could lead to new treatments
2. VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma
3. Single microRNA fine-tunes innate immune response
4. UNC researcher aims to unmask cancer cells to trigger bodys immune system
5. Immune Response May Hinder Stem Cell Treatments
6. Survivors of 1918 Flu Pandemic Immune 90 Years Later
7. B Cells Can Act Alone in Autoimmune Diseases
8. Targeted drug therapy found effective in patients with common form of immune-mediated kidney disease
9. Hyperactive immune resistance brings blindness in old age
10. Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease
11. HIV conquers immune system faster than previously realized
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 13, 2014 Recently, 2014QuinceaneraDresses.com, the ... unveiled its new range of gorgeous Quinceanera ... the demand for elegant Quinceanera outfits is huge. ... items. All the company’s newly released dresses are ... are all elegant and vivid. , It ...
(Date:7/13/2014)... MyDressCity.com, one of the most popular suppliers of wedding ... new range of elegant Quinceanera dresses . What’s ... prices. Worldwide clients can enjoy this special offer before ... shop, there are plenty of beautiful dresses for sale, ... MyDressCity.com’s hot items are prom gowns, bridesmaid gowns, wedding ...
(Date:7/13/2014)... 13, 2014 Epidemiologists forecast an increase ... 6MM, from 8,062 diagnosed incident cases in 2013 to ... Growth Rate (AGR) of 4.35%, during the forecast period. ... of diagnosed incident cases of aGVHD in the 6MM, ... the lowest number of diagnosed incident cases of aGVHD, ...
(Date:7/13/2014)... July 13, 2014 A decreased ability to ... impairment and Alzheimer,s disease, while examinations of the ... protein associated with Alzheimer,s, in the brain, according ... today at the Alzheimer,s Association International Conference 2014 ... the studies, the decreased ability to identify odors ...
(Date:7/13/2014)... 13, 2014 Wright & Schulte LLC ... been scheduled in July of 2015, in U.S. District ... are in the discovery process in the South ... is presiding over the multidistrict litigation (MDL). The complaints ... of individuals who allege that they took the statin ...
Breaking Medicine News(10 mins):Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 3Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 4Health News:Smell and eye tests show potential to detect Alzheimer's early 2Health News:Smell and eye tests show potential to detect Alzheimer's early 3Health News:Smell and eye tests show potential to detect Alzheimer's early 4Health News:Smell and eye tests show potential to detect Alzheimer's early 5Health News:Smell and eye tests show potential to detect Alzheimer's early 6Health News:Smell and eye tests show potential to detect Alzheimer's early 7Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4
... (SAN DIEGO, December 11, 2011) Asymptomatic patients ... of non-Hodgkin lymphoma, have traditionally been watched for ... treated with a combination of rituximab and chemotherapy ... have suggested a role for treatment of asymptomatic ...
... is the first to systematically review and analyze the literature ... findings show a 74 percent greater risk of overdose among ... reasons for the increased risk are biological and behavioral, but ... now available online in advance of print in the journal ...
... COLLEGE PARK, Md. - Over the past decade, attacks and ... the work of extremists from across the political spectrum - ... actors - says an analysis by the National Consortium for ... at the University of Maryland. The statistics underscore the ...
... Norwegian University of Life Sciences (UMB) and Forschungszentrum Jlich ... analyses of electrical activity in the brain. The method, ... and researchers to better interpret brain cell signals. In ... terms of interpreting for example EEG measurements, making diagnoses ...
... Dec. 10 (HealthDay News) -- Giving low-dose aspirin to patients ... the lungs could cut their odds of redeveloping the clots, ... venous thromboembolisms (VTEs). These can include both the leg clots ... lungs that can cause rapid pulse, shortness of breath, chest ...
... By Steven Reinberg HealthDay Reporter , ... recommended Thursday that several newer forms of oral contraceptives ... potentially fatal blood clots. The U.S. Food ... the new labels for oral contraceptives such as Bayer,s ...
Cached Medicine News:Health News:Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma 2Health News:Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma 3Health News:RI Hospital study analyzes link between HIV infection and overdose risk 2Health News:RI Hospital study analyzes link between HIV infection and overdose risk 3Health News:Growing US violent extremism by the numbers: UMD database 2Health News:Growing US violent extremism by the numbers: UMD database 3Health News:Tapping the brain orchestra 2Health News:Low-Dose Aspirin After Lung Clot Could Prevent Recurrence 2Health News:Low-Dose Aspirin After Lung Clot Could Prevent Recurrence 3Health News:FDA Advisers: Newer Forms of the 'Pill' Need Revised Warning Labels 2Health News:FDA Advisers: Newer Forms of the 'Pill' Need Revised Warning Labels 3
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... , Jan. 15, 2014 Sono-Tek Corporation (OTC BB: ... ended November 30, 2013, compared to sales of $2,202,000 for ... Once again, this quarter has also shown growth over the ... first quarter of this fiscal year. Markets that experienced sales ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
... Sankyo Company, Limited (hereafter, Daiichi Sankyo) today announced the ... direct oral once-daily Factor Xa inhibitor, significantly reduced the ... or hip arthroplasty, when compared to enoxaparin. Patients receiving ... deep vein thrombosis (DVT) and pulmonary embolism (PE) than ...
... /PRNewswire-Asia/ -- WuXi PharmaTech (NYSE: WX ), ... outsourcing company with operations in China and the United ... Science and Chemistry Awards, held on December 12, 2011 ... theme of this year,s awards was Disease Biology. Guowei ...
Cached Medicine Technology:Edoxaban Significantly Reduces Risk of Venous Thromboembolism by Half Compared to Enoxaparin in Japanese and Taiwanese Patients Following Knee or Hip Arthroplasty Surgery 2Edoxaban Significantly Reduces Risk of Venous Thromboembolism by Half Compared to Enoxaparin in Japanese and Taiwanese Patients Following Knee or Hip Arthroplasty Surgery 3Edoxaban Significantly Reduces Risk of Venous Thromboembolism by Half Compared to Enoxaparin in Japanese and Taiwanese Patients Following Knee or Hip Arthroplasty Surgery 4Edoxaban Significantly Reduces Risk of Venous Thromboembolism by Half Compared to Enoxaparin in Japanese and Taiwanese Patients Following Knee or Hip Arthroplasty Surgery 5WuXi PharmaTech Presents the 2011 Life Science and Chemistry Awards 2WuXi PharmaTech Presents the 2011 Life Science and Chemistry Awards 3
... the Anterior Segment The BD is optimized ... ophthalmologists specializing in the anterior segment. It is ... c-mount camera on the BD 900- may be ... in 10 and 16 X times- through the ...
... The system that makes it ... Molecular Biology Workstation is an automated ... known sequences, such as in the ... and Short Tandem Repeats (STRs) using ...
... an integrated filter made of pure ... filter provides protection against carryover and ... does not swell up as a ... then be recovered easily. In line ...
Optimized 180W Xenon lamp, low fan noise with reduced air turbulence, compact housing. Built for monitor applications and all endoscope dimensions. Ideal for video recording applications....
Medicine Products: