Navigation Links
Inhibitors of shuttle molecule show promise in acute leukemia
Date:6/19/2012

  • An estimated 10,200 Americans will die of acute myeloid leukemia (AML) in 2012, so new ways of treating the disease are needed.
  • This study uses a novel class of experimental drugs to halt a process that helps AML cells develop and survive.
  • The findings show that the agent is promising and should be considered for clinical trials testing.

COLUMBUS, Ohio A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia, according to a study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

The agents, called KPT-SINEs (selective inhibitors of nuclear export), target a transport protein called CRM1. Using acute myeloid leukemia (AML) cells and an animal model, the researchers showed that these agents inhibited leukemia-cell proliferation, arrested cell division, and induced cell death and differentiation.

In the animal model of AML, KPT-SINEs described by the researchers as one of the most advanced agents in pre-clinical development extended survival by 46 percent compared with controls.

KPT-SINEs were particularly effective when the leukemia cells also had mutations in the tumor-suppressor gene NPM1, which are present in about one-third of all adult AML.

The findings were published online in the journal Blood.

"Our study suggests that these agents might be an effective therapy for AML, particularly for patients with NPM1 mutations," says principal investigator Dr. Ramiro Garzon, assistant professor of medicine and a researcher with the OSUCCC James Molecular Biology and Cancer Genetics Program.

"We hope to start a phase I trial using one of these agents soon and to pursue further preclinical studies using this drug in combination with other current chemotherapies," Garzon says.

CRM1 normal
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecule movements that make us think
2. Prions in the brain eliminated by homing molecules
3. Researchers identify a life-and-death molecule on chronic leukemia cells
4. Early Study Finds Some Promise for Lung Cancer Vaccine
5. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
6. Nonsurgical Method to Measure Brain Pressure Shows Promise
7. Immunotherapy for elderly cancer patients finds new promise in drug combination
8. Experimental Pill for Multiple Sclerosis Shows Promise
9. Mechanical tissue resuscitation technology shows promise
10. Brain Tumor Vaccine Shows Promise in Early Trial
11. New Method to Reveal Alzheimers Marker Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... In an article published last month in Ergonomics ... occurring during the use of handheld electronic devices such as ... use of a tablet increases mechanical demand on neck muscles ... than when the neck is in a neutral position. Perhaps ... out the potential hazards of overuse of mobile technology may ...
(Date:4/25/2015)... 2015 The National League for ... national endeavor to prepare nurses to provide high quality, ... success, according to a new report by the John ... partners. , The project began in 2007 as ... the direction of Elaine Tagliareni, EdD, RN, CNE, FAAN, ...
(Date:4/25/2015)... Washington, D.C. (PRWEB) April 25, 2015 ... for Bangladesh Worker Safety issues the following statement following ... 7.8 earthquake hit Kathmandu, Nepal, resulting in the deaths ... this massive earthquake were felt across Nepal, Bangladesh, India ... to offer my heartfelt condolences to the people of ...
(Date:4/25/2015)... By definition, a CIO’s responsibility is to support ... on their judgement and expertise to keep digital assets and ... article published in National Mortgage News on April 22nd, ... disservice to their responsibilities by focusing too heavily on making ... when it comes to company policy and industry best practices, ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Parker and Sons ... and cooling, has spiked in Arizona alongside the growing economy. ... additional forty employees for April to help account for the ... forty employees in April is something we are enthusiastic about. ... said Paul Kelly, president at Parker and Sons. , Indeed, ...
Breaking Medicine News(10 mins):Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5Health News:Parker and Sons Plans to Expand in 2015 2
... Study says surgical advances may explain away the link ... News) -- Cataract surgery doesn,t hasten vision loss in ... conclusion of a new study that challenges the findings ... between cataract surgery and accelerated AMD progression. , AMD ...
... mouse model of human leukemia has provided critical insight into ... myeloid leukemia stem cells. The study, published by Cell Press ... Stem Cell , is likely to have a profound impact ... stem cells. , Leukemia stem cells (LSCs) were initially described ...
... Patient Advocate Foundation (NPAF) -- a national, non-profit organization ... patient access to health care through public policy reform ... Congress for passing and President Obama for signing the ... extend health coverage to four million uninsured American children. ...
... disease, A Su Salud revealed high incidence of diabetes, ... $55 million in free and low cost medical services ... -- CVS/pharmacy, the nation,s leading retail ... Salud" (To Your Health) health fairs, providing free health ...
... Montreal, Canada February 05, 2009 A ... who have received kidney transplants and compares them ... a significantly higher prevalence of psychiatric conditions (depression, ... adolescents who had undergone a transplant. The study ...
... recent survey of in-house,physician recruiters across the country ... on hospital systems throughout the United States, and,recruiting ... the lack,of physicians to fill key provider roles. ... from their most recent recruitment,and retention survey of ...
Cached Medicine News:Health News:Cataract Surgery Doesn't Worsen AMD 2Health News:Leukemia stem cells have more in common with embryonic stem cells than adult stem cells 2Health News:National Patient Advocate Foundation Applauds Congress' and President Obama's Decision to Extend Health Coverage to Four Million Uninsured Children 2Health News:CVS/pharmacy Launches 2009 'A Su Salud' Health Fairs Providing Free Health Screenings to the Community 2Health News:CVS/pharmacy Launches 2009 'A Su Salud' Health Fairs Providing Free Health Screenings to the Community 3Health News:Psychological impact found in adolescents with kidney transplants 2Health News:PracticeMatch: Healthcare Survey Defines Physician Recruitment Challenges 2
(Date:4/24/2015)... , April 24, 2015 ... of automated, indication-specific planning tools for radiosurgery/SBRT   ... software applications aimed at enhancing the workflow for ... spine introduced in 2013 - comes full circle ... planning tools. These new Elements enable on-the-fly generation ...
(Date:4/24/2015)... April 24, 2015 The National Institute ... the National Institutes of Health [NIH])  provided grants ... projects for the development of diagnostic tests for ... outbreaks at U.S. health facilities , the NIAID ... rapid, multiplexed and effective tests using alternative methods ...
(Date:4/24/2015)... -- Lannett Company, Inc. (NYSE: LCI ) today announced ... credit facility to $120 million from $50 million.  The ... the company to increase borrowings by a total of ... additional commitments from existing lenders or new lending institutions.  ... 18, 2018.   "The amended credit facility, ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4Lannett Expands Revolving Credit Facility To $120 Million 2
... Laboratories , announced today it has signed a marketing and ... LLY ) to market the Authorized Generic version ... Tablets, in the U.S. Prasco will begin ... the market.  Prasco will market all six strengths of Olanzapine ...
... 2011 InaVein, LLC today announced publication of a ... powered phlebectomy (TIPP) System for removal of varicose veins ... The paper, Transilluminated Powered Phlebectomy in an Office ... by Gregory A. Spitz, M.D., FACS (AmeriVein Systems, Aurora, ...
Cached Medicine Technology:Prasco® Selected as Eli Lilly and Company's Authorized Generics Partner 2InaVein, LLC Announces First Peer-reviewed Publication of TRIVEX® Used In-Office 2
Full Handle Laseredge Slit Blade Knife, 3.0 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.0 mm x 3.7 mm....
Full Handle Laseredge Slit Blade Knife, 2.85 mm slit. Blade tip dimension: 14.1 mm x 2.85 mm x 3.3 mm....
Full Handle Laseredge Slit Blade Knife, 2.65 mm angled double bevel. Blade tip dimension: N/A x 2.65 mm x N/A....
Full Handle Laseredge Slit Blade Knife, 2.65 mm angled bevel up. Blade tip dimension: 14.4 mm x 2.65 mm x 3.7 mm....
Medicine Products: