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Inhibition of oral biofilm and cell-cell communication using natural-products derivatives
Date:3/20/2014

indicating inhibition of AI-2 based QS. Gene expression analysis showed distinct down-regulation of genes previously related to quorum sensing and/or biofilm formation in S. mutans.

The use of plant-inspired cysteine derivatives to inhibit bacterial virulence may serve as a novel tool to improve oral health. The researchers of this study propose that the compounds used in this study may inhibit biofilm formation by interrupting bacterial communication pathways, particularly in AI-2 biosynthetic reactions. Since their library is derived from eukaryotic (plant) origins, this study may provide initial evidence of interkingdom signaling, which has implications for studies of the human microbiome.


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Contact: Ingrid L. Thomas
ithomas@aadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

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