Navigation Links
Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish

(PHILADELPHIA) Directly inhibiting the activity of a key protein mediator of inflammation reduced radiation toxicity in zebrafish embryos, and may ultimately be of help to patients receiving radiation therapy, according to researchers from the Kimmel Cancer Center at Jefferson.

Reporting in Molecular Cancer Therapeutics, the researchers found that inhibitors of NF-kappa B not only protected against radiation toxicity when given before exposure to treatment, but also lessened the radiation toxicity when given one to two hours post-exposure.

In the study, both NF-kappa B inhibitors and proteasome inhibitors were examined for their potential to alleviate the negative effects of radiation. However, the proteasome inhibitors tested, which included the FDA-approved bortezomib (Velcade), did not show the same effect. In fact, they actually exacerbated the harmful radiation effects.

"Although proteasome inhibitors demonstrate activity against NF-kappa B, they also target many other pathways," said Ulrich Rodeck, M.D., Ph.D., professor of Dermatology and Cutaneous Biology at Jefferson Medical College of Thomas Jefferson University. "We suspect that these agents may radiosensitize due to inhibition of these other targets."

This study was led by Dr. Rodeck and Adam Dicker, M.D., Ph.D., professor and interim chairman of the department Radiation Oncology at Jefferson.

"We started with the premise that NF-kappa B activity might be helpful in protecting cells against the harmful effects of radiation," Dr. Rodeck said. "We actually found quite the opposite - inhibiting the activity is an advantage that increased the survival in zebrafish and protected the individual organs from harmful effects of radiation."

According to Dr. Rodeck, the key is to downmodulate the NF-kappa B activity, rather than ablating it completely, as excessive NF-kappa B activation is potentially detrimental even in the absence of radiation therapy.

Drs. Rodeck and Dicker will be moving this research forward so that it may ultimately help individuals exposed to "dirty bombs," or cancer patients receiving radiation therapy. Their research team pioneered using zebrafish embryos as a vertebrate model system to investigate the effects of radiation therapy.


Contact: Emily Shafer
Thomas Jefferson University

Related medicine news :

1. Proteasome inhibition affects epigenetic mechanisms
2. An effective strategy for inhibition of cirrhosis
3. Webinar on June 25 to Focus on Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate
4. Researchers link inflammatory diseases to increased cardiovascular risk
5. Scientist at The Fienstein Instute for Medical Research Discovers Quitting Smoking Promotes Anti-Inflammatory Response
6. HerbalScience Research Identifies Specific Bioactives In Stabilized Rice Bran Extract that Impart Anti-Inflammatory Benefits
7. Study demonstrates the anti-inflammatory properties of pine bark extract
8. Study Demonstrates the Anti-Inflammatory Properties of Pine Bark Extract on Inflammatory Mediators COX-2 and 5-LOX
9. Oral/body inflammatory connection explained
10. Video: New Biological Therapy Ilaris(R) Approved in US to Treat Children and Adults with CAPS, a Serious Life-Long Auto-Inflammatory Disease
11. Drug May Help Against Inflammatory Breast Cancer
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... As part ... For Empowerment ™ attracts volunteers together who want to combine talents and resources ... key stakeholders in the process. The non-profit launched its first major fundraiser on ...
(Date:11/25/2015)... ... ... Finnleo, a leader in the traditional and far-infrared sauna industry, announced a sale ... , For traditional saunas, Finnleo is offering 20% off all Nordic Spruce ... only European Grade A Nordic White Spruce from sustainably grown trees. Because of the ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo ... parts and accessories. , Sauna accessories help improve the bather experience in the ... From basic styles for the purist looking for simplicity in design to accessories ...
(Date:11/25/2015)... , ... November 26, 2015 , ... ... Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public ... in Nairobi (UNON) for the opening of the 5th African Network for Drugs ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... CHAPEL HILL, N.C. , Nov. 24, 2015 /PRNewswire/ ... market research projects in an effort to quickly uncover ... market position. --> --> ... expeditiously launch a market research project and ensure that ... with company and industry standards. Another major barrier to ...
(Date:11/24/2015)... , 24. November 2015 ... Breathing Pacemaker Systems, ist erfreut, die Berufung ... Consultant bekannt geben zu können. ...   --> Foto - ... (Schweden). Von 1984-1986 war er Fellow ...
(Date:11/24/2015)... 24, 2015 Sectra (STO: SECT ... entered into a multi-year agreement to deploy Breast ... will provide the Breast Center a future-proof platform capable ... (STO: SECT B) announces that Breast Center of Acadiana ... Breast Imaging PACS in its two freestanding imaging centers. ...
Breaking Medicine Technology: