Navigation Links
Inhibition of GRK2 is protective against acute cardiac stress injuries
Date:11/17/2009

(PHILADELPHIA) Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion, according to two studies conducted at the Center for Translational Medicine at Thomas Jefferson University. The studies will be presented at the American Heart Association Scientific Sessions 2009 in Orlando, Fla.

The first study was presented by Henriette Brinks, M.D., a postdoctoral fellow in the Center for Translational Medicine. The researchers, led by Walter J. Koch, Ph.D., director of the Center for Translational Medicine, examined mice that overexpressed the G-Protein coupled Receptor Kinase-2 (GRK2). This overexpression was deleterious in ischemic myocardium, according to Dr. Koch, in that these mice had larger areas of infarction or myocardial death. However, inhibition of GRK2 activity with the peptide GRK2 inhibitor, ARKct, was cardioprotective, and resulted in less cell death and increased AKT signaling, with more viable myocardium and improved post-ischemic cardiac function.

In the second study, Dr. Koch, who is also the W.W. Smith Professor of Medicine at Jefferson Medical College of Thomas Jefferson University, and his team looked at mice that had a heart-specific deletion of the GRK2 gene. This study was presented by Erhe Gao, M.D., Ph.D, research associate professor in the Center for Translational Medicine. This study revealed that when the GRK2 protein is absent from heart cells, there is limited damage to the myocardium after ischemic injury, including decreased cell death. This leads to improved recovery from acute cardiac damage.

"We know that levels of GRK2 are increased in chronic heart failure, but studies have also shown that increases of GRK2 levels are one of the first changes observed after acute heart damages such as heart attack and ischemia," Dr. Koch said. "Both of these studies show that the absence of GRK2 activity protects the cardiac myocytes against ischemic reperfusion."

The results of these studies show that inhibiting GRK2 is a viable therapeutic approach that reduces acute ischemia injury to the myocardium, and is a strategy to limit acute myocardial ischemia.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish
2. Proteasome inhibition affects epigenetic mechanisms
3. An effective strategy for inhibition of cirrhosis
4. Webinar on June 25 to Focus on Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate
5. New York Merchants Protective Co. Designated as Authorized Geutebruck Solutions Provider
6. American Heart Association Meeting Report: High-Sugar Diet Increases Mens Blood Pressure; Gout Drug Protective
7. Makers of Trojan(R) Brand Condoms Introduce Trojan 2GO(R), a Unique, Portable, Protective and Discreet Packaging for Condoms
8. Flip for Fall Seasonal Household Tips Include Ten Million Reasons to Use Allergy-Protective Bedding
9. Personal Protective Equipment Conference Set for November 17 - 19 in Fort Lauderdale
10. New Study Reveals Mouthguards are Protective, but can Cause Harm
11. NBA All-Star Amare Stoudemire Discusses Season-Ending Eye Injury and the Importance of Protective Eyewear
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... ... January 21, 2017 , ... Pacifica Graduate ... the electrifying line-up of events for its annual meeting “Coming Home 2017,” an ... “Coming Home 2017” will be held on Friday January 27 through Sunday, ...
(Date:1/21/2017)... ... January 21, 2017 , ... In the United States, 20 million ... freedom of recovery, they often feel shame for having struggled with an eating disorder ... In the workshop, “Rising Strong in Life After an Eating Disorder” -- to be ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... A new ... donate items they no longer use or need, from clothes to couches to dressers ... unwanted items and take them to the nearest Goodwill donation center through February 28th. ...
(Date:1/20/2017)... ... January 20, 2017 , ... Doctor C LLC, a company based ... ECRM trade show to continue the marketing and distribution of its product, The Right ... providing 400 percent better absorption than traditional vitamin C supplements. At the trade show, ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... to enhance people’s everyday lives, recently attended the January ECRM Trade Show in ... Science is known for its large range of supplements that keep the body ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... January 20, 2017 ... an Nothilfe   Die internationale humanitäre Stadt soll ... zu schaffen   Seine Hoheit Scheich ... VAE sowie Herrscher von Dubai , ... der Hilfe (International Humanitarian City IHC) zu verdreifachen, um ...
(Date:1/19/2017)... , Jan. 19, 2017 The global ... billion by 2025, according to a new study ... anticipated to be predominantly driven by high R&D ... the large-scale production of new and therapeutically advanced ... of drugs at an unprecedented rate into the ...
(Date:1/19/2017)... Jan. 19, 2017 The U.S. Food and Drug ... Idiopathic Constipation (CIC) in adult patients. "No ... disorders," said Julie Beitz , M.D., director of the ... Drug Evaluation and Research. "With the availability of new therapies, ... for their condition." ...
Breaking Medicine Technology: