Navigation Links
Inhibition of GRK2 is protective against acute cardiac stress injuries
Date:11/17/2009

(PHILADELPHIA) Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion, according to two studies conducted at the Center for Translational Medicine at Thomas Jefferson University. The studies will be presented at the American Heart Association Scientific Sessions 2009 in Orlando, Fla.

The first study was presented by Henriette Brinks, M.D., a postdoctoral fellow in the Center for Translational Medicine. The researchers, led by Walter J. Koch, Ph.D., director of the Center for Translational Medicine, examined mice that overexpressed the G-Protein coupled Receptor Kinase-2 (GRK2). This overexpression was deleterious in ischemic myocardium, according to Dr. Koch, in that these mice had larger areas of infarction or myocardial death. However, inhibition of GRK2 activity with the peptide GRK2 inhibitor, ARKct, was cardioprotective, and resulted in less cell death and increased AKT signaling, with more viable myocardium and improved post-ischemic cardiac function.

In the second study, Dr. Koch, who is also the W.W. Smith Professor of Medicine at Jefferson Medical College of Thomas Jefferson University, and his team looked at mice that had a heart-specific deletion of the GRK2 gene. This study was presented by Erhe Gao, M.D., Ph.D, research associate professor in the Center for Translational Medicine. This study revealed that when the GRK2 protein is absent from heart cells, there is limited damage to the myocardium after ischemic injury, including decreased cell death. This leads to improved recovery from acute cardiac damage.

"We know that levels of GRK2 are increased in chronic heart failure, but studies have also shown that increases of GRK2 levels are one of the first changes observed after acute heart damages such as heart attack and ischemia," Dr. Koch said. "Both of these studies show that the absence of GRK2 activity protects the cardiac myocytes against ischemic reperfusion."

The results of these studies show that inhibiting GRK2 is a viable therapeutic approach that reduces acute ischemia injury to the myocardium, and is a strategy to limit acute myocardial ischemia.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish
2. Proteasome inhibition affects epigenetic mechanisms
3. An effective strategy for inhibition of cirrhosis
4. Webinar on June 25 to Focus on Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate
5. New York Merchants Protective Co. Designated as Authorized Geutebruck Solutions Provider
6. American Heart Association Meeting Report: High-Sugar Diet Increases Mens Blood Pressure; Gout Drug Protective
7. Makers of Trojan(R) Brand Condoms Introduce Trojan 2GO(R), a Unique, Portable, Protective and Discreet Packaging for Condoms
8. Flip for Fall Seasonal Household Tips Include Ten Million Reasons to Use Allergy-Protective Bedding
9. Personal Protective Equipment Conference Set for November 17 - 19 in Fort Lauderdale
10. New Study Reveals Mouthguards are Protective, but can Cause Harm
11. NBA All-Star Amare Stoudemire Discusses Season-Ending Eye Injury and the Importance of Protective Eyewear
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... Mich. (PRWEB) , ... October 12, 2017 , ... ... has been named one of Michigan’s 2017 Best and Brightest in Wellness® by ... Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Pa. and KALAMAZOO, Mich. , Sept. 18, ... , and OptiMed Specialty Pharmacy of ... to offer a strategic hub service that expedites and ... sought-after personal spirometer, Spiro PD 2.0, and wellness management ... spirometer is a medical device used to measure lung ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
(Date:9/12/2017)... N.J. , Sept. 12, 2017  Consumer reviews on the ... Hearing as the number one company for hearing aids, ranking ... and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high ...
Breaking Medicine Technology: