Navigation Links
Inhibiting prostate cancer without disturbing regular body processes
Date:8/9/2010

This release is available in French.

Inhibiting prostate cancer without disturbing regular body processes Researchers explain how a facultative enzyme governs tumour growth

A kinase is a type of enzyme the body uses to regulate the functions of the proteins required for cell growth and maintenance, and researchers have discovered that one in particular plays a key role in developing prostate cancer. "It's known as Mnk, and although it appears not to be essential for normal cell maintenance, it's important for cancer growth" said Dr. Luc Furic, a postdoctoral researcher working with Dr. Nahum Sonenberg at McGill University's Goodman Cancer Research Centre and Department of Biochemistry.

This is a very significant finding because the body's chemical processes are highly complex and interrelated, meaning that targeting one cause of cancer often involves affecting the body's normal functions. An important part of cancer research is about trying to find processes that can be inhibited or stopped without causing damages to normal tissue.

The chemical process Mnk uses is known as phosphorylation, and this process activates or inactivates the body's proteins, controlling mechanisms that can cause disease. In this case, Mnk works with a protein known as eIF4E to synthesize proteins in the cell.

Researchers at the Centre hospitalier de l'Universit de Montral Research Centre (CRCHUM), Universit de Montral and McGill University engineered mice that were able to block the phosphorylation process of this protein, and discovered that these mice became resistant to prostate cancer growth. "The PTEN gene and its protein act as a tumour suppressor," explained Dr. Fred Saad, researcher at the CRCHUM and at Universit de Montral's Department of Surgery. "By removing this gene in the mouse prostate, we were able to study eIF4E's effect on cell growth."

The research is directly related to humans, because PTEN is frequently mutated in human prostate cancer. Studies on cancer patients have confirmed eIF4E's involvement.

The task ahead will be to find a specific and selective pharmacological inhibitor of Mnks. Although some inhibitors are used for research purposes, these inhibitors are not highly specific to this kinase.


'/>"/>

Contact: William Raillant-Clark
william.raillant-clark@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related medicine news :

1. Inhibiting fatty acids in immune cells decreases atherosclerosis risk
2. Advance Toward Test for Aggressive Prostate Cancer
3. DASH FOR DAD Race Series Coming to 11 Cities to Raise Prostate Cancer Awareness
4. Jim Huber to Serve as National Spokesman for Know Your Score: Fight Prostate Campaign at Myrtle Beach Golf Holiday in August
5. Few differences in outcomes between open and laparoscopic prostate surgery
6. Two Surgical Methods Equally Successful for Prostate Cancer
7. Genetic Mutation Linked to Prostate Cancer in Blacks
8. Statins May Benefit Prostate Cancer Patients
9. Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010
10. Be a Star Athlete in the Fight Against Prostate Cancer
11. Do men with early prostate cancer commit suicide more frequently?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen ... Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years ... three acupuncturists to help patients realize their family building goals. Acupuncture helps ...
(Date:12/7/2016)... ... (PRWEB) December 07, 2016 , ... Angioma ... by cerebral cavernous angiomas, was awarded a grant from the Julian Grace Foundation ... New Mexico has more people with cavernous angioma than anywhere in the world. ...
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... their brain networks that can be seen on a type of MRI, according ... is a progressive disorder of the central nervous system characterized by tremors or ...
(Date:12/6/2016)... ... , ... An inventor, from Talladega, Ala., thought there needed to be a ... SLING-VEST. , The SLING-VEST provides an effective way to support and align the arm ... a result, it helps to reduce discomfort and shifting. The invention features an effective ...
(Date:12/6/2016)... ... 2016 , ... In anticipation for the New Year, Dr. Mayoor Patel has ... courses in 2017, dentists of all levels can continue to advance the services offered ... attend a variety of continuing education courses each month on topics ranging from sleep ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)...  Nearly 30 million people in the ... diabetes. 1 However, nearly 40% of diabetes patients ... and significant glucose variability. 2 These patients are at ... If left untreated, hyperglycemia can lead to cardiovascular disease, ... 3 As part of Diabetes Awareness ...
(Date:12/6/2016)... , Dec. 6, 2016  Arcturus Therapeutics, Inc. ... company, announced today that it entered into collaboration ... therapeutics for the treatment of NASH and other ... delivery platform LUNAR™ and UNA Oligomer chemistry. The ... Takeda,s long-standing commitment to and expertise in GI ...
(Date:12/6/2016)... Delaware , December 6, 2016 Breast Pump ... per a new research report by Global Market Insights, Inc. ... ... logo , ... Increasing global population, growing women employment rates and rising consumer awareness regarding ...
Breaking Medicine Technology: