Navigation Links
Inhibiting key enzymes kills difficult tumor cells in mice
Date:8/15/2011

Tumors that do not respond to chemotherapy are the target of a cancer therapy that prevents the function of two enzymes in mouse tumor cells, according to Pennsylvania medical researchers.

"We've known for well over a decade that when tumors become hypoxic they become resistant to chemotherapy and radiotherapy," said Wafik S. El-Deiry, M.D. Ph.D., American Cancer Society Research Professor, Rose Dunlap Professor and chief of hematology/oncology, Penn State College of Medicine. "This is a huge problem in the treatment of patients with cancer. As tumors progress, they have regions that are not well perfused with blood vessels and tumors become hypoxic."

A hypoxic tumor lacks oxygen because there are not enough blood vessels within the tumor to allow red blood cells to transport oxygen throughout the tumor.

El-Deiry and his team report in a recent issue of Cancer Research that the drug sangivamycin-like molecule 3 (SLM3) helps keep tumor cells from multiplying in lab mice.

Treating a tumor with SLM3 inhibits two kinase, or enzymes: GSK-3, which regulates cell growth and cell death, and CDK1, which regulates cell division and blood vessel growth. Tumor cells treated with SLM3 become more sensitive to chemotherapy and die, according to El-Deiry and his colleagues.

"If you just inhibit GSK-3, that may not be enough and not necessarily desirable," said El-Deiry, who is also the associate director for translational research, Cancer Institute. "But there's something fortuitous about the dual targeting of these two kinases, (GSK-3 and CDK-1), with respect to cancer therapy. If you inhibit these two kinases, the dual inhibition works together to kill hypoxic tumor cells.

"While pure inhibition of GSK-3 can promote cell proliferation, the combination of GSK-3 and CDK-1 inhibition not only inhibits cell proliferation but also promotes cell death," El-Deiry added.

To find SLM3, the researchers screened a chemical library looking for molecul
'/>"/>

Contact: Victoria M. Indivero
vmi1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Inhibiting fatty acids in immune cells decreases atherosclerosis risk
2. Inhibiting prostate cancer without disturbing regular body processes
3. Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
4. New evidence that smokeless tobacco damages DNA and key enzymes
5. Heart Enzymes May Predict Outcome After Bypass Surgery
6. New York Truck Driver Watching Porn Kills Mother, Appalls Personal Injury Lawyers Such As David Perecman
7. Cognitive Skills May Shrink With Tamoxifen
8. Stethoscope App gives iPhone New Clinical Skills
9. Paper Kills 2.0 Book by Center for Health Transformation Features Chapter by StatCom
10. PeopleStreme Collaborates with SkillSoft for Learning Management Content
11. New agent chokes off energy supply, kills cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... Park Cities Pet Sitter is offering a 5-week “Training and ... June 6th at 10:30am. The classes will be held ... with a maximum of six dogs allowed in the class. ... class being held over the 4th of July weekend. ... level class, dogs will solidify their practical behavior skills, but ...
(Date:5/28/2015)... Galloway Township, NJ (PRWEB) May 28, 2015 ... a gift of $2,500 from Horizon Blue Cross Blue Shield ... of pro golfer Natalie Gulbis, the club can receive much ... Classic Presented by Acer. , A former Boys & Girls ... growing up in Sacramento, California, Ms. Gulbis has accepted the ...
(Date:5/28/2015)... May 28, 2015 Dr. Jenyons’ ... an exclusive deal to patients looking to undergo its ... through 30, patients will be able to get a ... for just $600. For a three-treatment package, which costs ... at no cost. , Dr. Juanita Jenyons, M.D., says ...
(Date:5/28/2015)... 2015 AMVETS leaders this week congratulated ... Robert Davis of Newark, Del. AMVETS National Commander Larry ... winning the $10,000 sweepstakes grand prize. , AMVETS selected ... from around the country for prizes ranging from $500 ... on May 21 at the AMVETS National Headquarters in ...
(Date:5/28/2015)... Melbourne, Florida (PRWEB) May 28, 2015 ... facial plastic surgeon , has hired Teresa Beard as ... Specialists. In her role, Beard will oversee all marketing ... 20 years of experience leading teams and developing compelling ... Clevens Face and Body Specialists, Beard served as guest ...
Breaking Medicine News(10 mins):Health News:Dallas-based Park Cities Pet Sitter to Offer “Training and Enrichment 2” Group Dog Training Class Beginning Saturday, June 6th, 2015. 2Health News:Dallas-based Park Cities Pet Sitter to Offer “Training and Enrichment 2” Group Dog Training Class Beginning Saturday, June 6th, 2015. 3Health News:Golf Pro Natalie Gulbis to Chip in with Horizon Blue Cross Blue Shield of New Jersey to Support Boys & Girls Club of Atlantic City 2Health News:Golf Pro Natalie Gulbis to Chip in with Horizon Blue Cross Blue Shield of New Jersey to Support Boys & Girls Club of Atlantic City 3Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 3Health News:AMVETS Announces Summer Sweepstakes Winners 2Health News:Clevens Face and Body Specialists Welcomes Teresa Beard as Marketing Director 2
... of thiamine (vitamin B1) states that a deficiency in ... surgery to treat obesity//. This is based on ... the American Academy of Neurology. ,The ... can lead to Wernicke’s encephalopathy, a severe neurological condition. ...
... or sell Viagra, as they fear it may result in ... ,"We will not sale the drug as it may lead ... problems," said Amar Sinha, general secretary of the Jharkhand Chemist ... added: "The common practice here is to sell medicines even ...
... The Westin Hotels and Resorts has banned smoking in the ... in the US, Canada and the Caribbean from January 2006//., ... or in other outdoor areas. , ,Westin said research ... wanted a non-smoking room. , ,"Nobody likes to walk ...
... out OraTest, its detection drug for oral cancer, according to ... is caused by chewing tobacco and smoking. ,The ... with oral cancer every year. Marc Robins, founder of The ... are subduing the dangers of breast and cervical cancers in ...
... Picower Institute for Learning and Memory shows that neurons tend to ... of adult brain // lacks the capacity to grow as a ... research on the various techniques that could induce growth in the ... genetic or the sensory or by other ways that could lead ...
... and Finch showed the effect of childhood infections and ... diseases // . ,They collected mortality data ... and Switzerland from different years but ending with individuals ... was an important factor in treating childhood illness. ...
Cached Medicine News:Health News:More The Usage More The Growth In The Adult Brain. 2
(Date:5/28/2015)...   Eli Lilly and Company (NYSE: LLY ) ... webcast on June 11 to discuss data from the first ... from these two trials, RA-BEACON and RA-BUILD, will be presented ... Congress 2015 in Rome, Italy . ... Eastern Daylight Time. The live audio webcast can be accessed ...
(Date:5/28/2015)... U.S. Department of Justice (DOJ) has entered into a ... to resolve a lawsuit that began more than five ... by two former employees of Orbit.  The whistleblowers alleged ... of Orbit,s top executives, Jake Kilgore , forged ... Medicare for electric wheelchairs.  The lawsuit was brought under ...
(Date:5/28/2015)... PORTLAND, Oregon , May 28, 2015 ... titled, "Global Syphilis Testing Market - Size, Industry Analysis, Trends, Opportunities, ... market to reach $3.6 billion by 2020. The secondary ... segment through 2020. Latin America , ... Africa (LAMEA) market accounted for about 43% ...
Breaking Medicine Technology:Lilly and Incyte Announce Webcast to Discuss Baricitinib Phase III Data 2Lilly and Incyte Announce Webcast to Discuss Baricitinib Phase III Data 3Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 2Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 3Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 4Global Syphilis Testing Market is Expected to Reach $3.6 Billion, by 2020 - Allied Market Research 2Global Syphilis Testing Market is Expected to Reach $3.6 Billion, by 2020 - Allied Market Research 3
... Seal-Away CS and Alliance Catheter ... for the introduction of catheters ... sinus from a superior approach. ... Medical's outstanding peel-away introducer performance ...
... the world leader in peel-away introducers. ... for permanent pacemaker and defibrillator lead ... implantation, and for temporary pacemaker insertions. ... Medical Peel-Away introducers includes the Di-Lock™ ...
The RX HERCULINK® PLUS Biliary Stent System is Guidant's high performance .014" guide wire compatible system. It is available in stent diameters of 4.0-6.5mm for the 12mm stent length and 4.0-7.0...
... catheters comprise the world's broadest line ... procedures. Their advanced catheter design and ... response with a soft, atraumatic tip. ... sizes, Supreme and Response catheters provide ...
Medicine Products: