Navigation Links
Inhibiting fatty acids in immune cells decreases atherosclerosis risk
Date:7/23/2010

substance called fatty acid synthase. This enzyme converts dietary sugars into fatty acids in the liver, where it plays an important role in energy metabolism. But fatty acids also are involved in atherosclerosis.

"The plaques that clog arteries contain large amounts of fatty acids," says senior investigator Clay F. Semenkovich, MD. "We engineered mice that are unable to make fatty acid synthase in one of the major cell types that contribute to plaque formation. On a standard Western diet high in fat, the mice had less atherosclerosis than their normal littermates."

Animals can't survive without fatty acid synthase, so mice in this study were able to make the substance in most of their tissues. They couldn't manufacture it, however, in macrophages, a type of white blood cell that surrounds and kills invading microorganisms, removes dead cells from the body and stimulates the action of other immune cells. Macrophages are dispatched in response to injury, infection and inflammation.

Atherosclerosis is the most common cause of heart disease, which is the leading cause of death in the United States. Semenkovich, the Herbert S. Gasser Professor and chief of the Division of Endocrinology, Metabolism and Lipid Research, says doctors tend to concentrate on treating the surrounding risk factors related to atherosclerosis, such as diabetes and high blood pressure, but he says the blockages themselves cause the most serious, life-threatening problems.

"With the current epidemic of obesity and diabetes, people sometimes forget that it's the blockages in the arteries that really kill people," he says. "We've made progress using statin drugs, for example, that lower cholesterol and fight plaque buildup, but a lot of people who take statins still die from cardiovascular disease. We need better therapies."

These mouse experiments suggest targeting fatty acid synthase in macrophages may provide a potential treatment strategy for humans.
'/>"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Fatty acid to enhance anticancer drug
2. Researchers Identify 2 Genes Linked to Fatty Liver Disease
3. Studies Detail Possible Benefits of omega-3 Fatty Acids for Dogs With Arthritis
4. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
5. UCLA scientists create army of tumor-fighting immune cells and watch as they attack cancer
6. New Anti-HIV Weapons Found in Immune System
7. Genetic regulator opens new avenues to AIDS, immune system research
8. Unlocking the Immune System's Response to Infection and Injury
9. Gene Mutations Offer Clues to Autoimmune Disorders
10. How bacteria boost the immune system
11. Immune system helps transplanted stem cells navigate in central nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhibiting fatty acids in immune cells decreases atherosclerosis risk
(Date:9/17/2014)... 17, 2014 (HealthDay News) -- A blood test that ... doctors with a better assessment of the state of ... If used routinely, this blood test could reveal when ... actually begins promoting tumor growth, the researchers suggested. ... patients with advanced prostate cancer and often initially very ...
(Date:9/17/2014)... this month for the November elections, one of the ... out the chamber door will be the Sustainable Growth ... of 2014. In a new commentary in the journal ... he and other advocates saw as the merits of ... Medicare pays doctors will return for the next Congress, ...
(Date:9/17/2014)... (PRWEB) September 18, 2014 Many countries ... influenza, instead of immunizations. The total number of poultry ... difficult to control, will result in huge losses. Therefore, ... avian influenza vaccines. , Avian influenza vaccines have been ... poultry farms in China began to use H5N1 avian ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Smart Flour ... Picks by Progressive Grocer, a leading trade magazine targeted ... awarded for originality and flavor, among other attributes. Smart ... an Editor’s Pick in the September print issue of ... website. , The pizza won based on its superior ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 A petition ... ) in laparoscopic hysterectomies and other gynecological surgeries has ... to figures posted on Change.org, at least 84,908 supporters ... , According to a recent report from ABC News, ... by Dr. Hooman Noorchashm, after his wife, Dr. Amy ...
Breaking Medicine News(10 mins):Health News:DNA Blood Test Might Identify Status of Prostate Cancer 2Health News:Failed Medicare payments law remains relevant 2Health News:Failed Medicare payments law remains relevant 3Health News:China Avian Influenza Vaccine Industry 2014-2018 Research Report Now Available at LifeScienceIndustryResearch.com 2Health News:China Avian Influenza Vaccine Industry 2014-2018 Research Report Now Available at LifeScienceIndustryResearch.com 3Health News:Smart Flour Foods Wins 2014 Progressive Grocer Editor’s Pick Award 2Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Petition Nears 85,000 Signatures, Bernstein Liebhard LLP Reports 4
... American Associations for Dental Research announced that its Journal ... Five-Year Scientific Impact Factor (SIF) from 4.195 to 4.389. In ... #1 in Article Influence. This news comes from the new ... Journal Citation Reports (JCR). This latest report also shows that ...
... researchers from Boston University School of Medicine (BUSM) and ... high rate of thyroid function testing in pregnant women. ... the Journal of Clinical Endocrinology & Metabolism , ... testing on pregnant women, approximately 80 percent of cases ...
... has discovered in young adult mice that a lone brain stem ... to specialized neurons and glia important types of brain cells ... new brain stem cells. A report on their study appears ... that the brain has the capacity to generate both neurons, which ...
... HealthDay Reporter , THURSDAY, June 30 (HealthDay News) -- The ... rooms for drinking-related injuries doubles over the July 4th weekend, ... sends a daily average of nearly 1,000 youth under 21 ... problems related to alcohol use, according to a report by ...
... Italy, 30 June 2011 Differences in male and female ... be more verbally fluent, have better manual dexterity and are ... the other hand often take less time parking their cars ... new city. The latter capacities, in which men tend to ...
... Insomnia is the most prevalent sleep disorder, affecting ... the United States on a weekly basis. ... ever, randomized, controlled clinical research study in the country ... Optimization is a non-invasive technology that helps the brain ...
Cached Medicine News:Health News:Journal of Dental Research increases its scientific impact factor 2Health News:BMC conducts high rates of thyroid testing in pregnant women, study finds 2Health News:Nervous system stem cells can replace themselves, give rise to variety of cell types, even amplify 2Health News:July 4 Weekend Dangerous for Underage Boys Who Drink: Report 2Health News:Sound localization at cocktail parties is easier for men 2Health News:Wake Forest Baptist conducts clinical study for insomnia using new technology 2
(Date:9/17/2014)... Sept. 17, 2014  Aratana Therapeutics, Inc. (NASDAQ: ... on licensing, developing and commercializing innovative biopharmaceutical products ... its public offering of 4,500,000 shares of its common stock ... per share. Aratana has granted the underwriters a ... 675,000 shares of its common stock. ...
(Date:9/17/2014)... Cardiac Dimensions ® , Inc. today announced ... II clinical trial of its enhanced CARILLON Mitral ... mitral regurgitation, functional improvement, quality of life and ... data, which was consistent with previous trials of ... 26 th annual Transcatheter Cardiovascular Therapeutics Conference ...
(Date:9/17/2014)... , Sept. 17, 2014  Neuraltus Pharmaceuticals, Inc. announced ... 2 clinical program of NP001 for the treatment of ... disease) are being highlighted today in an oral presentation ... Group , being held in Bloomington, Minnesota ... hoc  analysis, administration of a high dose of NP001 ...
Breaking Medicine Technology:Aratana Therapeutics, Inc. Announces Pricing of Public Offering 2Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 2Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 3Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 3
... Texas, Sept. 26, 2011 Vermillion, Inc. ... today announced the appointment of Donald Munroe, Ph.D. as ...  He will be responsible for furthering development of Vermillion,s ... continue the preclinical studies and initiate appropriate clinical studies ...
... SAN DIEGO, Sept. 26, 2011 Elevation Pharmaceuticals, Inc., ... aerosol therapies for patients with respiratory diseases, today announced ... and Chief Business Officer and Pravin Soni, PhD, as ... created positions. The company also announced that it drew ...
Cached Medicine Technology:Vermillion Enhances Management Team With A Key Addition 2Vermillion Enhances Management Team With A Key Addition 3Vermillion Enhances Management Team With A Key Addition 4Elevation Pharmaceuticals Strengthens Management Team with Appointment of Executives 2Elevation Pharmaceuticals Strengthens Management Team with Appointment of Executives 3
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: