Navigation Links
Inhibiting Protein May Keep Cancer Cells From Refueling
Date:11/20/2008

Researchers say finding could be key to new disease-fighting therapies

THURSDAY, Nov. 20 (HealthDay News) -- New research on mice suggests inhibiting a protein that allows certain tumor cells to refuel may prove to be key to cancer-fighting treatments.

A study by Pierre Sonveaux and colleagues at Universite catholique de Louvain, in Belgium, found that tumor cells use different fuel sources depending on whether they are in regions rich in oxygen or deprived of oxygen, called hypoxic regions. The researchers found that cells in hypoxic regions use glucose to generate energy, but well-oxygenated tumor cells instead use lactate.

The findings were published in the Nov. 20 online issue of The Journal of Clinical Investigation.

By inhibiting the protein MCT1, which takes in the lactate to convert it to fuel, in the well-oxygenated cells, they switched to using glucose. This upset the symbiotic relationship between the hypoxic and well-oxygenated tumor cells, causing decreased tumor growth in two mouse models.

As the hypoxic tumor cells became deprived of the glucose now going to the oxygen-rich tumor cells, they became sensitive to irradiation.

More information

The U.S. National Cancer Institute has more about biological cancer therapies.



-- Kevin McKeever



SOURCE: The Journal of Clinical Investigation, news release, Nov. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhibiting Protein May Keep Cancer Cells From Refueling
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: