Navigation Links
Inhibiting Protein May Keep Cancer Cells From Refueling
Date:11/20/2008

Researchers say finding could be key to new disease-fighting therapies

THURSDAY, Nov. 20 (HealthDay News) -- New research on mice suggests inhibiting a protein that allows certain tumor cells to refuel may prove to be key to cancer-fighting treatments.

A study by Pierre Sonveaux and colleagues at Universite catholique de Louvain, in Belgium, found that tumor cells use different fuel sources depending on whether they are in regions rich in oxygen or deprived of oxygen, called hypoxic regions. The researchers found that cells in hypoxic regions use glucose to generate energy, but well-oxygenated tumor cells instead use lactate.

The findings were published in the Nov. 20 online issue of The Journal of Clinical Investigation.

By inhibiting the protein MCT1, which takes in the lactate to convert it to fuel, in the well-oxygenated cells, they switched to using glucose. This upset the symbiotic relationship between the hypoxic and well-oxygenated tumor cells, causing decreased tumor growth in two mouse models.

As the hypoxic tumor cells became deprived of the glucose now going to the oxygen-rich tumor cells, they became sensitive to irradiation.

More information

The U.S. National Cancer Institute has more about biological cancer therapies.



-- Kevin McKeever



SOURCE: The Journal of Clinical Investigation, news release, Nov. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhibiting Protein May Keep Cancer Cells From Refueling
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
Breaking Medicine Technology: