Navigation Links
Inhibiting Protein May Keep Cancer Cells From Refueling
Date:11/20/2008

Researchers say finding could be key to new disease-fighting therapies

THURSDAY, Nov. 20 (HealthDay News) -- New research on mice suggests inhibiting a protein that allows certain tumor cells to refuel may prove to be key to cancer-fighting treatments.

A study by Pierre Sonveaux and colleagues at Universite catholique de Louvain, in Belgium, found that tumor cells use different fuel sources depending on whether they are in regions rich in oxygen or deprived of oxygen, called hypoxic regions. The researchers found that cells in hypoxic regions use glucose to generate energy, but well-oxygenated tumor cells instead use lactate.

The findings were published in the Nov. 20 online issue of The Journal of Clinical Investigation.

By inhibiting the protein MCT1, which takes in the lactate to convert it to fuel, in the well-oxygenated cells, they switched to using glucose. This upset the symbiotic relationship between the hypoxic and well-oxygenated tumor cells, causing decreased tumor growth in two mouse models.

As the hypoxic tumor cells became deprived of the glucose now going to the oxygen-rich tumor cells, they became sensitive to irradiation.

More information

The U.S. National Cancer Institute has more about biological cancer therapies.



-- Kevin McKeever



SOURCE: The Journal of Clinical Investigation, news release, Nov. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhibiting Protein May Keep Cancer Cells From Refueling
(Date:2/28/2015)... 28, 2015 Pioneer Millworks reclaimed USA ... Architecture & Construction Materials Show, an annual, premier sustainable ... 1,000 suppliers and top manufacturers of the latest building ... products sourced and manufactured by Pioneer Millworks from ... in Japan at restaurants, hotels, retailers, and corporate offices. ...
(Date:2/28/2015)... A case management conference ( http://www.testosteronelawsuithub.com/ ... been filed by law firms including Bernstein Liebhard LLP ... the Firm notes. , According to a Calendar ... federal litigation will meet on March 13, 2015 at ... treatments designed to raise levels of the male hormone. ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 The noted ... announce that they have officially relaunched their website. The ... user-friendly, but it contains a new section about their ... to read the full biographies of each Friedman Dental ... of the website was designed to provide our patients ...
(Date:2/28/2015)... 2015 “ Powermod ” was featured on ... a look at the latest and coolest technology products and ... NewsWatch and a technology expert, conducted the review and shared ... solutions. , Getting stuck with a low battery and no ... that people face on a daily basis. Even when a ...
(Date:2/28/2015)... My Shiney Hiney® LLC., the renowned brand in personal ... Nevada for the annual ASD Market Week tradeshow. , ... tradeshows and My Shiney Hiney will be one of the ... can be found at booth number C1663. , My Shiney ... hygiene brush and cleansing system exclusively created to clean and ...
Breaking Medicine News(10 mins):Health News:US Reclaimed Wood from Pioneer Millworks to be Featured at Architecture & Construction Materials Show in Tokyo. 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 3Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 4Health News:Friedman Dental Group Announces Their Updated Website 2Health News:Solutions to Keep Phones Charged were Featured on NewsWatch Television on January 29, 2015 2Health News:My Shiney Hiney® to Participate in ASD Market Week 2015 2
... Society, the leading professional and scientific organization dedicated to the ... Francesca M. Dea, CAE, to serve as the Society,s Executive ... with an accomplished record in nonprofit and small business management, ... Robert Kushner, MD, President of The Obesity Society, "We,re excited ...
... , MONDAY, July 6 (HealthDay News) -- A U.S. ... breast cancer cells survive in the bone marrow of patients ... issue of the journal Cancer Cell , could lead ... the researchers. , "We sought to identify signaling pathways that ...
... and Johns Hopkins University School of Medicine have collaborated ... of autism. Their new study, published in the journal ... children with autism and typically developing children learned to ... with autism appear to learn new actions differently than ...
... July 6, 2009 -- In a study to determine ... decision to treat nonmetastatic breast cancer, researchers at Columbia ... between oncologist characteristics and the receipt of chemotherapy in ... were more likely to receive chemotherapy if treated by ...
... of Arizona has announced that AM 1230 KOY will begin ... SCAN Health Plan to regularly share its health-related messages with ... , SCAN also will serve as a co-sponsor to KOY ... This initiative is part of the nonprofit health plan,s ongoing ...
... National Science Foundation (NSF) has awarded a four-year, ... Science Laboratory (NDSSL) at the Virginia Bioinformatics Institute ... petascale computing environments that model billions of individuals ... The anticipated arrival of high-performance computers that ...
Cached Medicine News:Health News:The Obesity Society Selects Executive Vice President 2Health News:Research Reveals Clues to Breast Cancer's Spread 2Health News:New study pinpoints difference in the way children with autism learn new behaviors 2Health News:New study pinpoints difference in the way children with autism learn new behaviors 3Health News:Elderly breast cancer patients receive chemotherapy if treated in private practices 2Health News:Elderly breast cancer patients receive chemotherapy if treated in private practices 3Health News:Arizona's AM 1230 KOY to be Broadcast from SCAN Health Plan Studios 2Health News:Virginia Bioinformatics Institute to develop petascale computer modeling capabilities 2Health News:Virginia Bioinformatics Institute to develop petascale computer modeling capabilities 3Health News:Virginia Bioinformatics Institute to develop petascale computer modeling capabilities 4
(Date:2/27/2015)... -- Bionik Laboratories Corp. (OTC:DWTPD), a Delaware ... Bionik Laboratories, Inc., a Toronto ... accredited investors of units consisting of its common stock ... million. Shares of the Company,s common stock will continue ... symbol "DWTPD" until FINRA,s approval of the ticker "BNKL." ...
(Date:2/26/2015)... , February 27, 2015 ... H2 2014 market research report to its store. ... Corneal Ulcers, therapeutic pipeline. The report ... on the therapeutic development for Corneal Ulcers. Corneal ... that includes bacterial infections, viral infections & fungal ...
(Date:2/26/2015)... 2015  IRIDEX Corporation (NASDAQ: IRIX ) today ... year 2014 financial results after the market closes on ... the Company will host a conference call with the investment ... Thursday, March 5, 2015 to discuss the results of ... may access the live conference call via telephone by dialing ...
Breaking Medicine Technology:Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2
... 2011 SurgiCount Medical, Inc., the wholly-owned operating subsidiary ... today announced that it has signed an agreement, effective ... in one of the largest hospital operators in the ... a minimum number of hospitals, SurgiCount and the operator ...
... HeartWare International, Inc. (NASDAQ: HTWR ; ASX: ... support technologies that are revolutionizing the treatment of advanced ... HeartWare® Ventricular Assist System will be presented on Sunday, ... in Lisbon, Portugal. A presentation by Mark ...
Cached Medicine Technology:SurgiCount Medical Announces Agreement with 130+ Hospital Operator to Implement the Safety-Sponge® System 2SurgiCount Medical Announces Agreement with 130+ Hospital Operator to Implement the Safety-Sponge® System 3HeartWare Announces Presentation of Clinical Data at the 25th European Association for Cardio-Thoracic Surgery (EACTS) Annual Meeting in Lisbon 2
... will be the world wide sole distributor ... different from conventional drug eluting stents, the ... drug eluting stent designed to provide advanced ... allow release profiles to be tailored to ...
... background in high performance portable ultrasound ... field of echocardiography. Echocardiography (ultrasound) ... frame rates, and sensitive Doppler performance. ... based upon Terason's proprietary Teratech Architecture, ...
... myocardial infarction is suspected, every ... rapid assay allows rapid determination ... T from a single whole ... is available within minutes - ...
For the quantitative determination of human MMP-9/NGAL Complex concentrations in cell culture supernates, serum,plasma, urine and saliva....
Medicine Products: