Navigation Links
Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia
Date:8/16/2009

ited variations in ARID5B might also influence patient response to chemotherapy, particularly to the drug methotrexate. "We found this same inherited variation also affected accumulation of the drug in leukemia cells. It accumulates better. That allows us to use a lower dose and still cure the leukemia," Relling explained. "These findings may identify a new marker that could be used to help decide on doses of methotrexate in patients with varying ARID5B status."

Scientists are not sure how the SNPs they identified influence cancer risk. But studies of variation in gene expression associated with the ARID5B gene indicate the inherited variations have a biological function. Researchers must still determine what it is.

Other authors of this paper include Lisa Trevino, Wenjian Yang, Deborah French, Geoffrey Neale, James Downing, Susana Raimondi, Ching-Hon Pui and William Evans, all of St. Jude; Stephen Hunger, University of Colorado, Denver; William Carroll, New York University Medical Center, New York; Meenakshi Devidas, University of Florida, Gainesville; and Cheryl Willman, University of New Mexico, Albuquerque.

This study was supported by the National Cancer Institute, the National Institutes of Health/National Institutes of General Medical Sciences Pharmacogenetics Research Network and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraisi
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Gene newly linked to inherited ALS may also play role in common dementia
2. Different mutations in single gene suggest Parkinsons is primarily an inherited genetic disorder
3. Inherited melanoma risk: What you do know does help you
4. Gene Mutation Tied to Inherited Atrial Fibrillation
5. Inherited form of hearing loss stems from gene mutation
6. New findings may improve treatment of inherited breast cancer
7. Turning back the Clock in Inherited Anemias
8. Gene Mutation Tied to Inherited Fatal Lung Disease
9. Gene Mutation Linked to Inherited ALS
10. Personalized genome sequencing reveals coding error in gene for inherited pancreatic cancer
11. Study gives more proof that intelligence is largely inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... July 13, 2014 Chromatography system ... components from various types of biological samples such ... the sample mixture into two phase, namely mobile ... mobile phase run over the stationary phase, followed ... components that provide the separation of mixture. Chromatography ...
(Date:7/13/2014)... 13, 2014 Recently, MillionaireCasket.com, a well-known casket ... oak caskets . Additionally, the company’s chief executive officer has ... new oak caskets are offered at discounted prices, from 15 ... concerned, quality caskets are in huge demand in the current ... caskets . We have a lot of high quality products ...
(Date:7/13/2014)... BC (PRWEB) July 13, 2014 Victorian ... excitement by promoting the rental of bikes for its ... historic downtown Victorian Hotel to tour the area using ... plus tax. Bicycle enthusiasts love to call Vancouver home, ... options for cycle travel and picturesque journeys through the ...
(Date:7/13/2014)... The North American water storage systems market is ... million by 2018, at a CAGR of 21.0%, from 2013 ... a rapid pace in North America. The U.S. is experiencing ... & wastewater storage and collection, and the increased spending on ... at a healthy rate in Canada, and is rising at ...
(Date:7/13/2014)... 13, 2014 Micro irrigation systems are ... water dispersal as wells as to maintain soil quality. ... projected to become a dominant revenue generator for manufacturers ... to reduce resource costs has led to the adoption ... and has further caused massive demand for micro irrigation ...
Breaking Medicine News(10 mins):Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 2Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 3Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3
... , ... York, PLLC (APNY), a group of 18 established and highly regarded pediatrics practices in Queens, ... the reach of their care to extend to thousands more New York children than in ... (Vocus) March ...
... ... ... ... ...
... ... ... , , , , ... ...
... depression, PTSD, bipolar disorder in most cases, study ... -- A single-page questionnaire can help primary-care doctors ... report. , Called My Mood Monitor (M-3), the ... depression, bipolar disorder, anxiety disorders and post-traumatic stress ...
... research into how diabetics could possibly preserve their eyesight ... of children afflicted with retinoblastoma. Dolores Takemoto, a ... protein kinase C gamma in the lens of the ... when she discovered a correlation between the protein Coonexin46 ...
... Promega and ... monitoring apoptosis in live mammals, an important biomarker in cancer studies. , ... Madison, WI (PRWEB) March 9, 2010 -- Promega ... for monitoring apoptosis in live mammals, an important biomarker in cancer studies. Under the agreement, ...
Cached Medicine News:Health News:Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers 2Health News:Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers 3Health News:Parrish Medical Center Sees 30 Percent Improvement in Mortality Using Real-Time Clinical Surveillance Solution from Thomson Reuters 2Health News:Parrish Medical Center Sees 30 Percent Improvement in Mortality Using Real-Time Clinical Surveillance Solution from Thomson Reuters 3Health News:Parrish Medical Center Sees 30 Percent Improvement in Mortality Using Real-Time Clinical Surveillance Solution from Thomson Reuters 4Health News:Parrish Medical Center Sees 30 Percent Improvement in Mortality Using Real-Time Clinical Surveillance Solution from Thomson Reuters 5Health News:K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity 2Health News:K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity 3Health News:K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity 4Health News:K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity 5Health News:K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity 6Health News:Survey May Help Docs Diagnose Mood Disorders 2Health News:K-State professor finds link between low oxygen levels in body and cancer-aiding protein 2Health News:Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies 2
(Date:7/11/2014)... DALLAS , July 11, 2014 ... report "Scintillator Market by Composition of Material, Application ... and others), End Product (Personal Instrument, Hand-Held Instruments, ... Forecast and Analysis to 2013 - 2020", published by MarketsandMarkets, ... a CAGR of 5.62% from 2014 to 2020, ...
(Date:7/11/2014)... July 11, 2014 On ... down 0.52%, the Dow Jones Industrial Average finished the day ... 1,964.68, down 0.41%. The losses were broad based as eight ... S&P 500 Health Care Sector Index ended the day at ... the last one month. Investor-Edge has initiated coverage on the ...
(Date:7/11/2014)... Show organisers report ... Expo 2014 were a brand new audience ... London , plus a 10% increase ...      (Logo: http://photos.prnewswire.com/prnh/20130723/629764-a) ...      (Photo: http://photos.prnewswire.com/prnh/20140711/696892-b ) ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
... Ontario, April 1, 2011 Promius Pharma, LLC, an ... ), and Valeant Pharmaceuticals International, Inc. (NYSE: ... have signed a collaboration agreement for Cloderm® (clocortolone pivalate ... an upfront payment and pay future royalties as the ...
... CarePoint Partners, one of the largest, fastest growing ... launched a food drive today throughout its twenty-one locations ... the communities where it operates. Called the "Got Food?" ... of April. CarePoint Partners is partnering with its healthcare ...
Cached Medicine Technology:Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 2Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 3Promius Pharma and Valeant Form Collaboration to Market Cloderm® Cream in the United States 4CarePoint Partners Kicks Off Food Drive to Help Fight Hunger in Twenty-One Local Communities 2