Navigation Links
Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia
Date:8/16/2009

d additional cases for genetic analysis. COG is an international group of medical institutions that cooperate in research studies and clinical trials of childhood cancer treatment.

Researchers scanned the genomes of 441 children with ALL and a control group of 17,958 cancer-free individuals for more than 300,000 common genetic variations known as single nucleotide polymorphisms or SNPs.

The search found 18 SNPs that differed significantly in frequency between individuals with and without ALL. Six of the 18 SNPs were associated with one of the four main subtypes of ALL.

The six included two SNPs linked to the ARID5B gene. About 11 percent of those in the control group inherit the leukemia-risk ARID5B variations from both mother and father, Relling said. In comparison, the same high-risk ARID5B SNPs were found in 38 percent of patients with a type of ALL known as hyperdiploid ALL. That subtype accounts for about 20 percent of ALL patients.

Three more SNPs were traced to the genes IKZF1 and DDC, which are next to each other on chromosome 7. IKZF1 is also known as IKAROS. Earlier research from St. Jude and COG linked acquired changes in IKZF1 to an increased risk of ALL relapse. The new evidence tying inherited variation in IKZF1 to an increased risk of developing ALL underscores the need for medications targeting variations in this gene, Relling said.

Both ARID5B and IKZF1 play important roles in normal development of lymphoid or white blood cells, she said. ARID5B belongs to a family of genes that make transcription factors, which help regulate gene activity. "If they have an inherited variation that affects the function of those genes, these are plausible pathways for how a normal lymphoid cell could be disrupted and transformed into a cancer cell," Relling said.

Inher
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Gene newly linked to inherited ALS may also play role in common dementia
2. Different mutations in single gene suggest Parkinsons is primarily an inherited genetic disorder
3. Inherited melanoma risk: What you do know does help you
4. Gene Mutation Tied to Inherited Atrial Fibrillation
5. Inherited form of hearing loss stems from gene mutation
6. New findings may improve treatment of inherited breast cancer
7. Turning back the Clock in Inherited Anemias
8. Gene Mutation Tied to Inherited Fatal Lung Disease
9. Gene Mutation Linked to Inherited ALS
10. Personalized genome sequencing reveals coding error in gene for inherited pancreatic cancer
11. Study gives more proof that intelligence is largely inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 Power morcellator lawsuits ( http://www.gynecaremorcellatorlawsuit.com/ ... behalf of women who allegedly experienced the spread of ... reports. According to court documents, one of the most ... U.S. District Court, Northern District of New York, on ... of a power morcellator manufactured Karl Storz Endoscopy - ...
(Date:8/27/2014)... What’s next for 14 year old Sriram Hathwar, ... Spelling Bee? Sririam will visit Philadelphia on Friday, August ... Eye Hospital.     , The teen from Painted Post, New ... , Wills Eye Ophthalmologist-in-Chief, Dr. Julia Haller will show ... diagnostic testing. He will also tour historic Philadelphia ...
(Date:8/27/2014)... The newest Abington Health Center ... 8, 2014. This new 15,000 square foot, $5 million ... care practices and walk-in laboratory services. , ... endeavor for Abington Health as the healthcare landscape changes,” ... “Establishing a location in Lower Gwynedd allows us to ...
(Date:8/27/2014)... -- Overconfident people are better at convincing others that ... are more likely to get promotions and reach high-level ... that these "self-deceived" people are also more likely to ... And finally, people who underestimate themselves are regarded ... British researchers. Their findings were published Aug. 27 in ...
(Date:8/27/2014)... Recent growth in health care spending for commercially ... for medical services, rather than increased use, according to ... Institute for Health Policy & Clinical Practice, published in ... Managed Care . , There is increasing concern that ... increased prices faced by payers and, ultimately, consumers," said ...
Breaking Medicine News(10 mins):Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 4Health News:Scripps National Spelling Bee Co-Champion and Aspiring Ophthalmologist Coming to Wills Eye Hospital in Philadelphia 2Health News:Abington Health Opens New Health Center in Lower Gwynedd 2Health News:Overconfident Folks May Blind Others to Their Real Abilities 2Health News:Tracking spending among the commercially insured 2
... Windows Vista, Adobe Flash 10 and high-availability failover support. , ... ... today announced the release of the latest version of the industry ... of CoolSign further builds on its existing enterprise-based, robust feature set, ...
... 2009 As Zimbabwe continues to confront a,cholera ... a new,World Vision project supported by the Procter ... Drinking Water Program is underway, providing Zimbabweans with ... families and their,communities. , ...
... a limited edition beauty bag filled with products as ... Wash. and NEW YORK, Feb. 24 Beauty.com, Inc., ... DSCM ), announces Shoshanna Gruss as their ... program. Beginning February 25th, the exclusive Shoshanna-designed beauty case ...
... Them Crazy While They Work...30,000+ Dentists Converge in Chicago ... being issued by the Chicago Dental Society:Who: The ... members to find out some wacky, unusual, and just ... their chair.As we countdown to CDS,s annual Midwinter Meeting, ...
... dental techniques, , , TUESDAY, Feb. 24 (HealthDay News) -- ... and the development of skin and the nervous system ... University researchers have found. , Their discovery about the ... methods of repairing damaged enamel and preventing cavities, restoring ...
... promiscuity, experts stress, , , TUESDAY, Feb. 24 (HealthDay News) -- ... have sex, but a new study provides another suggestion that ... and teenage sexual activity. , The findings indicate that ... more likely to copy or emulate what they hear," said ...
Cached Medicine News:Health News:Procter & Gamble and World Vision Equip and Empower Zimbabweans in Fight Against Cholera 2Health News:Procter & Gamble and World Vision Equip and Empower Zimbabweans in Fight Against Cholera 3Health News:NY Fashion Designer Shoshanna Creates Exclusive Spring Bag for Beauty.com 2Health News:NY Fashion Designer Shoshanna Creates Exclusive Spring Bag for Beauty.com 3Health News:Top 5 Most Annoying Dental Patient Behaviors 2Health News:Scientists Find Gene for Tooth Enamel 2Health News:'Degrading' Lyrics Linked to Teen Sex 2Health News:'Degrading' Lyrics Linked to Teen Sex 3
(Date:8/27/2014)... -- CVS Caremark (NYSE: CVS ) announced today ... MedStar Health, a leading health care system with ten ... Washington, DC , region, which will ... patients. Through this clinical affiliation, MedStar Health patients will ... chronic disease monitoring and wellness programs at CVS/pharmacy stores ...
(Date:8/27/2014)... NINGBO, China , Aug. 27, 2014  Amerigen ... Ltd, ("Menovo") today announced they had entered into a ... targeting the United States market. ... will jointly develop products for Amerigen to commercialize in ... be responsible for manufacturing API and finished product whereas ...
(Date:8/27/2014)... DALLAS , Aug. 27, 2014 /PRNewswire-iReach/ -- "Fatty ... data on the Fatty Liver Disease clinical trial scenario. ... the clinical trials on Fatty Liver Disease . ... their recruitment status as per the site of trial ... coverage of disease clinical trials by their phase, trial ...
Breaking Medicine Technology:CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 2Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 3Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 4Fatty Liver Disease Therapeutics Clinical Trials Market Review 2014 Analysis Report Available at MarketOptimizer.org 5
Liquichek Pediatric Control is a product designed to monitor important analytes for neonatal testing. This control monitors four bilirubin parameters at two clinically significant levels....
... Chemistry Control (Human) provides a comprehensive ... enzymes and CO2. It requires no ... most major instruments and methodologies. Available ... fill sizes (10 mL fill size ...
Liquid Assayed and Unassayed Multiqual Controls are comprehensive, liquid, human serum based chemistry controls, available in three levels....
Lyphochek® Drug Free Serum can serve as a drug-free baseline for HPLC analysis or as a negative control....
Medicine Products: