Navigation Links
Inhaled steroids increase diabetes risk, say Lady Davis Institute researchers

This release is available in French.

Patients taking inhaled corticosteroids are at increased risk of developing type 2 diabetes, and more so with higher doses, say researchers at the Jewish General Hospital's Lady Davis Institute for Medical Research (LDI) In Montreal. The risk is of special concern for patients suffering from chronic obstructive pulmonary disorder (COPD), and much less significant for asthmatics.

"These medications are very effective in asthma, so the benefits clearly outweigh the risk for asthmatics," said Dr. Samy Suissa, Director of the Centre for Clinical Epidemiology at the LDI, and lead author of the study published in the American Journal of Medicine. "However, their effectiveness is questionable in COPD, where they are also used in higher doses. This is a very different risk/benefit situation."

Inhaled corticosteroids are administered in the form of aerosol sprays and micropowders, and include drugs like fluticasone (Flonase, Advair), budesonide (Pulmicort, Rhinocort) and beclometasone (QVAR, Beclovent), among others.

Oral corticosteroids like predinisone have long been known to increase the risk of diabetes, but this is the first time the effect has been observed with the inhaled form.

Suissa and his colleagues used the extensive databases of Quebec's provincial health insurance board to study a cohort of nearly 400,000 patients treated for COPD or asthma. They determined that inhaled corticosteroids increased the rate of onset of diabetes from 14 people per 1000 to 19 per 1000, or 34 percent, every year of use. In other words, 5 additional people for every 1000 users in the study people who otherwise would not have been affected developed diabetes from the use of the drug.

"These are not insubstantial numbers," said Dr. Suissa, also a professor of epidemiology and biostatistics at McGill University in Montreal. "Over a large population the absolute numbers of affected people are significant.

"We recommend that physicians reserve the use of inhaled steroids for the patients who truly benefit from these medications, namely asthmatics, and curb their use in COPD to the few patients for whom they are indicated. In all cases, patients using high doses should be assessed for possible hyperglycemia and the lowest effective dose targeted."


Contact: Mark Shainblum
514-340-8222 x6592
Jewish General Hospital

Related medicine news :

1. New Inhaled Insulin Shows Promise for Diabetes
2. Steroids Could Harm Hearts Pumping Ability
3. Study finds post-transplant patients off steroids have fewer cardiovascular events
4. Fountain of youth steroids could protect against heart disease
5. IV Steroids May Be Overkill in COPD Patients
6. Governor Rendell Proposes Budget With No Tax Increase, More Money for Public Schools, Strategy for Jobs, Plan to Address Future Deficits
7. Soft drinks may increase risk of pancreatic cancer
8. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
10. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
11. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
Post Your Comments:
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
Breaking Medicine Technology: