Navigation Links
Ingredient in New MS Drug Linked to Serious Brain Disease
Date:4/24/2013

By Brenda Goodman
HealthDay Reporter

WEDNESDAY, April 24 (HealthDay News) -- The active ingredient in a drug that's expected to become a popular treatment for multiple sclerosis has been linked to four European cases of a rare but sometimes fatal brain disease called progressive multifocal leukoencephalopathy (PML).

The ingredient, dimethyl fumarate, is used in a drug called Fumaderm that was approved in Germany in 1994 to treat the skin condition psoriasis. It is also in a different but closely related medication called Tecfidera, which was just approved by the U.S. Food and Drug Administration in March for the treatment of multiple sclerosis (MS). It is known as a fumaric acid ester, which is commonly used as a food additive and has been used to treat psoriasis in Germany for 30 years.

According to reports published in the April 25 issue of the New England Journal of Medicine, however, four patients who were taking Fumaderm to treat their psoriasis developed PML.

In a letter responding to the reports, Biogen, the company that makes both drugs, said Tecfidera may be safer because it contains only dimethyl fumarate, while Fumaderm also contains three other fumaric acid esters.

The company also noted that none of the patients taking Tecfidera during clinical trials (then known as BG-12) developed PML. Since Tecfidera is a pill rather than an injection, and was effective and well-tolerated by patients in clinical trials, analysts have predicted it would soon become the top-selling multiple sclerosis treatment.

But the German doctor who treated one of the psoriasis patients who got PML thinks there is still cause for concern.

Dr. Jorg Schulz, a neurologist at Rheinisch-Westfaelische Technische Hochschule Aachen, a research university in Aachen, said the two drugs are virtually identical once they are broken down in the body.

"The problem is that the studies with BG-12 covered a two-ye
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Revitol Rosacea Now Comes with Anti-Inflammatory Ingredients to Remove Redness and Flushing
2. Wartrol Warts Relief Formula Now Comes With FDA Approved Ingredients For Fast Actions
3. Simply Eight Expands Distribution Of Its Simple Ingredient Foods
4. Advance in re-engineering photosynthesis to make drugs, compounds or ingredients
5. Capsiplex Fat Burner Formula with Red Pepper and Other Useful Ingredients for Quick Weight Loss
6. Some Kids Abusing Common Baking Ingredients
7. WeightWise Infographic Spotlights Twinkies Ingredients’ Non-Food Uses
8. EverydayVitamin.com Carries New Patented Satiereal® Saffron Extract Products: Proven Ingredient for Weight Loss
9. Pure Cocoa Powder, the Key Ingredient in Dark Chocolate and Found in Diabetes Support Supplements has been Clinically Proven to Reduce Cardiovascular Risk
10. Supplement of Red Wine Ingredient Wont Help Healthy Women: Study
11. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ingredient in New MS Drug Linked to Serious Brain Disease
(Date:12/22/2014)... CA (PRWEB) December 22, 2014 ... now offering consultations for sleep apnea. Drowsy drivers are ... than drivers who are well-rested, and some experts believe ... the roads as intoxicated drivers. Unfortunately, millions of Americans ... the American Academy of Sleep Medicine, about 18 million ...
(Date:12/22/2014)... Luxury Linen purveyor Peacock Alley ... to provide logistics and support for one of Dallas’ ... a long history of giving back to the community in ... year's Toy Drive were Whataburger® and 99.5 The Wolf. , ... holidays. Providing gifts to children who would otherwise not receive ...
(Date:12/22/2014)... 21, 2014 A substantial percentage ... computed tomography (CT) to evaluate abnormal findings on ... cancer, according to a new study published online ... the findings show that radiologist recommendations for additional ... to patient care. , RAIs, which have grown ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 In ... is segmented by power source, product, and application. ... electric-powered, battery-powered, and pneumatic instruments. By product, the ... and accessories segments. The handpieces market is further ... devices, suction coagulators, laparoscopic instruments, shavers, wire/pin drivers, ...
(Date:12/21/2014)... 2014 Khanna Vision Institute is pleased ... the Aspen Helicopters holiday event for underprivileged kids. The ... sleigh, flown by an aspen helicopter pilot. In the ... with sleigh was visible.(please see accompanying video). Helicopter pilots ... has helped many pilots with Pi in eye vision ...
Breaking Medicine News(10 mins):Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 2Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 4
... chromosomes can break and reshuffle pieces of themselves is nothing ... cells. The rules for where chromosomes are likely to break ... now starting to come into view. Researchers at Children,s Hospital ... those rules into clearer focus by discovering that where each ...
... PHILADELPHIA -- In an effort to reduce and eventually eliminate ... Kimmel Cancer Center at Jefferson has established the ... P. Mitchell, M.D., FACP , a medical oncologist at ... and Medical Oncology in the Department of Medical Oncology at ...
... 16 (HealthDay News) -- About 7.5 million American children under ... with alcohol abuse over the past year, a new government ... across the country, say researchers at the Substance Abuse and ... "The enormity of this public health problem goes well ...
... Feb. 16 (HealthDay News) -- Researchers have sequenced the genomes ... transmissible facial cancer that threatens the species with extinction. ... found only on the Australian island of Tasmania, according to ... Cell . "There are targeted drugs that work ...
... painACTION.com is a free, non-promotional online program designed ... people with chronic pain. This study tested painACTION.com,s ... in people with chronic migraine headaches. A total ... to painACTION.com were more confident that they could ...
... JOLLA,CA -- Drugs targeting an enzyme involved in inflammation might ... to a new study by scientists at the Salk Institute ... activity of the enzyme IKK2, which helps activate the body,s ... lung cancer and increased their lifespan. The findings, ...
Cached Medicine News:Health News:To understand chromosome reshuffling, look to the genome's 3D structure 2Health News:To understand chromosome reshuffling, look to the genome's 3D structure 3Health News:To understand chromosome reshuffling, look to the genome's 3D structure 4Health News:Jefferson's Kimmel Cancer Center establishes Center to Eliminate Cancer Disparities 2Health News:Jefferson's Kimmel Cancer Center establishes Center to Eliminate Cancer Disparities 3Health News:Genome Map Might Help Save Tasmanian Devil From Extinction 2Health News:painACTION.com improves migraine self-management and reduces migraine-related psychological distress 2Health News:Salk researchers find new drug target for lung cancer 2Health News:Salk researchers find new drug target for lung cancer 3
(Date:12/19/2014)... Dec. 19, 2014  Advanced Medical Isotope Corporation ... engaged primarily in the development of brachytherapy devices ... today announced that a Life Sciences Discovery Fund ... for which AMIC is the commercialization partner.  The ... for the proposal titled "Optimized Injectable Radiogels for ...
(Date:12/19/2014)... N.C. , Dec. 19, 2014 ... optimize a product,s web presence to reflect the ... websites, in particular, must meet the needs of ... and culture. According to recent ... than half of the participating companies averaged more ...
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. ... (NASDAQ: SRNE ;  Sorrento), an oncology ... pain, and Conkwest, Inc., a privately-held immuno-oncology company ... Killer (NK) cell-line based therapy, announced today that ... to jointly develop next generation CAR-TNK™ (pronounced as ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Building a Best-in-Class Pharma Global Brand Website 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... high-power, long-pulse Nd:YAG technology provides practitioners with the ... lesions and perform permanent hair reduction on all ... size feature allows the practitioner to instantly switch ... spot size with a simple twist of the ...
...
...
... is your system. CONMED's family of products ... New, state-of-the art generators feature proprietary Energy ... continuous synchronization of current and voltage in ... enables the system to sample current and ...
Medicine Products: