Navigation Links
Infusion of stem cells and specially generated T-cells from same donor improves leukemia survival
Date:2/27/2013

SEATTLE In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. Both the stem cells for transplant and the T-cells came from the same matched donors.

Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine, researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilm's Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic.

The best results were achieved when some of the patients received T-cell clones that were exposed to interleukin 21 (IL-21) during the programming and growth process, based on the hypothesis that such exposure would create cells that could survive longer and produce greater anti-leukemic activity after transfer. IL-21 promotes T-cell expansion while helping those cells acquire characteristics of central memory T-cells.

"This is the first time patients have received an infusion of WT1 specific T-cells, and thus also the first demonstration that such cells can provide a therapeutic anti-leukemic effect, as has been suggested from earlier vaccine trials that induce less potent responses," said Philip Greenberg, M.D., corresponding author and head of the Immunology Program at Fred Hutch.

"Ours is also the first report to show that greatly improved T-cell in-vivo persistence can be achieved after transfer by modifying the way cells are generated in tissue culture for therapy with inclusion of the cytokine IL-21," said Aude Chapuis, M.D.
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Energy Infusion Meets Skin Care: Introducing Dahryn Silver Gel™
2. Acutrack integrates with Infusionsoft ecommerce platform
3. CareFusion, Baxter and Hospira Lead the Infusion Therapy Market as Hospitalization in the U.S. Climbs Reports iData Research
4. New drug prevents spread of human prostate cancer cells
5. Tiny hitchhikers attack cancer cells
6. To prevent leukemias dreaded return, go for the stem cells
7. Scientists identify major source of cells defense against oxidative stress
8. Therapy exploits addiction of leukemia cells
9. IBN discovers human neural stem cells with tumor targeting ability
10. Leukaemia cells have a remembrance of things past
11. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, 2014 (HealthDay ... for health workers treating Ebola patients, now requiring full body ... at all times. The U.S. Centers for Disease Control ... Dallas nurses contracted Ebola while caring for the first ... Duncan. Nina Pham is currently being treated for her infection ...
(Date:10/20/2014)... Texas (PRWEB) October 20, 2014 The ... the must-have source of thousands of facts, figures and ... countries and 68 medical sector forecast categories the ... with global, regional and national views on the worldwide ... outlook. , The report gives you data for 2010-2019, ...
(Date:10/20/2014)... 2014 Allegheny General Hospital’s (AGH) Cardiovascular ... physicians to repair a damaged mitral valve as the ... system, developed by Abbott Vascular , is designed ... life-threatening condition in which the heart’s mitral valve leaflets ... from the heart’s left ventricle into the left atrium. ...
Breaking Medicine News(10 mins):Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... WEDNESDAY, Nov. 16 (HealthDay News) -- Broken heart syndrome -- ... emotional stress -- occurs overwhelmingly in women compared to men, ... death of a loved one, a frightening medical diagnosis, a ... 7.5 times more common in females, and women older than ...
... Orange, NJ. Nov. 15, 2011. John DeLuca, PhD, ... on the use of a behavioral technique for cognitive ... investigator was Nancy Chiaravalloti, PhD, director of the Neuropsychology ... on modified Story Memory Technique was made on October ...
... Calif. Tumors can grow for 10 years or longer ... mathematical model developed by Stanford University School of Medicine scientists ... is broadly applicable across all solid tumor types, will be ... "The study,s results can be viewed as both bad ...
... Nov. 16 (HealthDay News) -- ,Losing weight appears to help ... 31 obese people who underwent treatment for gum disease. Half ... had gastric bypass weight loss surgery and also had fat ... of 35) did not have gastric bypass surgery or fat ...
... the emerging field of nanomedicine a breathtaking technological revolution ... diseases? Or does it portend the release of dangerous ... in the body? A new review of more than ... is likely. It appears in ACS, journal Molecular ...
... A study of burn patients has found that those who ... and spent more time on ventilators and in intensive care. ... Stritch School of Medicine, is published ahead of print in ... first to show that the severity of smoke-inhalation injury may ...
Cached Medicine News:Health News:Women More Prone to 'Broken Heart' Syndrome: Study 2Health News:Women More Prone to 'Broken Heart' Syndrome: Study 3Health News:New Stanford model establishes guidelines for earlier cancer detection 2Health News:New Stanford model establishes guidelines for earlier cancer detection 3Health News:New Stanford model establishes guidelines for earlier cancer detection 4Health News:Study documents toll of smoke inhalation injuries 2
(Date:10/20/2014)... VIEW, California , 20 de octubre de ... líder en el campo de la pulmonología intervencional, ... su Estudio RENEW, casi 3 meses antes de ... fundamental de exención de dispositivo de investigación (IDE) ... Medicamentos) para el sistema de espiral de reducción ...
(Date:10/20/2014)... 2014  ResMed (NYSE: RMD ) ... Exchange program, a comprehensive suite of software and ... other health care providers. ResMed ... patient information. It integrates valuable sleep and respiratory ... management platforms with customers, in-house or third-party electronic ...
(Date:10/20/2014)... SAN DIEGO , Oct. 20, 2014 /PRNewswire/ ... development of therapeutic antibodies, today announced the appointment ... Development Officer. Dr. Londei will lead the preclinical ... "We are pleased to welcome ... Hamza Suria , President and Chief Executive ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... 16, 2011 InspireMD, Inc. (OTC BB: NSPR) ... mesh protective stent system, today announced that it has ... 30, 2011 with the U.S. Securities and Exchange Commission. The ... Year-to-Date Highlights Year-to-date shipment volumes ...
... 2011 Beacon Enterprise Solutions Group, Inc. (OTC ... leader in the design, implementation and management of ... today announces the award from teaming partner ICS ... leading provider of innovative technologies and solutions, to ...
Cached Medicine Technology:InspireMD Provides Mid-Year Strategic Update 2InspireMD Provides Mid-Year Strategic Update 3InspireMD Provides Mid-Year Strategic Update 4InspireMD Provides Mid-Year Strategic Update 5InspireMD Provides Mid-Year Strategic Update 6InspireMD Provides Mid-Year Strategic Update 7Beacon Enterprise Solutions Announces $3.4 Million Contract Award With the Veteran's Administration 2Beacon Enterprise Solutions Announces $3.4 Million Contract Award With the Veteran's Administration 3
Flagship Transcranial Doppler system with multiple channel options, multi-depth options....
Swiss Watchmaker Forceps, 4" extra-long precision ground points....
... have very fine tips and are intended for ... is required. The curved ones are ideal for ... shards. The student versions are for beginners. These ... static free. The Swiss forceps are made from ...
Verte-Span is the latest advancement in vertebral body replacement technology. This device allows surgeons to reconstruct and stabilize certain types of anterior column defects in the spine....
Medicine Products: