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Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patients
Date:9/23/2011

and this therapy will be an early choice for patients with liver-only disease."

Former president of ECCO and Director General of the Institut de Cancrologie Gustave Roussy (Paris, France), Professor Alexander Eggermont said: "The maturity of the data presented today better depicts the value as well as the limitations of percutaneous hepatic perfusion. One of the interesting points is that, in these relatively good patients, those that crossed over from the BAC arm of the study have good progression-free survival after a 'late' PHP that is about the same as when PHP is given upfront. In the absence of identified targets for targeted drugs in uveal melanoma, one might consider testing the role of ipilimumab following a PHP."

ESMO spokesman, Professor Ulrich Keilholz, of the Department of Hematology and Medical Oncology and Deputy Director at the Charit Comprehensive Cancer Center, Berlin, Germany, said: "The study by Pingpank is the first phase III trial in uveal melanoma and the first trial to show a benefit of regional treatment for liver metastases in this disease. Given the current lack of targeted drugs in this disease in contrast to the emerging treatments in cutaneous melanoma the clinically relevant benefit achieved with melphalan perfusion provides a new reference treatment for patients with hepatic metastases of uveal melanoma."


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Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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