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Informed consent: False positives not a worry in lung cancer study
Date:7/24/2014

factors that could have had a confounding influence. Whether participants received X-rays or the helical CT scans, the questionnaire scores of those with false positive diagnoses remained similar to those who were given true negative diagnoses.

Meanwhile, the scores of the true positive participants who were diagnosed with lung cancer markedly worsened over time as their battle with the disease took a physical and psychological toll.

Because participants received the questionnaires at one and six months, it is possible that study participants receiving a false positive screen result experienced anxiety and reduced quality of life for a short time after receiving their screen result, Gareen said. But by one month after their screening, there was no evidence of a difference between the screen result groups.

Gareen said the results should encourage physicians to recommend appropriate screenings, despite their high false positive rates, so long as patients are properly informed of the likelihood of a positive screen result and its implications. The data provide evidence that the NLST consent process provided a good model for advising those undergoing screening, she said.


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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

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