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Influenza: Insights into cell specificity of human vs. avian viruses
Date:10/9/2007

bute to the pathogenicity.

These data are consistent with the differences in human disease presentation, with human influenza causing tracheobronchitis and highly pathogenic avian influenza causing severe pneumonia. But which animal models are the best for studying the disease in humans" To answer this question, the authors next assessed the pattern of virus attachment in animal models used for influenza studies. Of several mammals tested, ferrets, cats, and pigs most closely resembled the human patterns of virus attachment for avian influenza viruses, thus demonstrating their usefulness as models of infection and disease.

These studies improve our understanding of the pathogenesis of human respiratory tract disease from both human and avian influenza A virus infection, state the authors. Combined with the results obtained with different animal models, they may lead to a better understanding of the factors that are critical for virus binding and infection, enabling the future development and testing of feasible control strategies.


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Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
Source:Eurekalert

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