Navigation Links
Inflammatory protein converts glioblastoma cells into most aggressive version
Date:8/29/2013

,270 people will receive a glioblastoma diagnosis in 2013 and about 14,000 people will die of the disease. Median survival is about one year.

Cell line, mouse model show something missing

"No one really knows how glioblastoma progresses from its early stages because 90-95 percent of cases are diagnosed without prior history of a lower grade glioma," Bhat said. Of these about 50 percent belong to the MES subgroup. A previous study had shown that glioblastomas with a proneural (PN) type, have a much better prognosis. But these less-aggressive tumors tend to recur as the aggressive MES subtype after treatment."

Research at MD Anderson and other institutions identified the two distinct cell types based on genes expressed by each. "We haven't known what makes a cell evolve into the MES subtype," Bhat said.

Bhat took cells from 41 human glioblastoma samples and placed them in cell cultures. Of these, 33 developed into neurospheres, cells that take on stem-cell like characteristics.

Microarray analysis of gene expression in the 17 fastest -expanding cell cultures divided them into two distinct groups: one cluster similar to the MES subtype and the other the PN subtype.

They analyzed expression of four genes commonly expressed by each subtype to see how the cultured cells matched up to their parental tumors.

Cue the surprise

All but two of the cell lines (70 percent) that originated from MES tumors lost their MES characteristics and acquired a PN signature. These results do not match the human experience, Bhat noted. Glioblastoma cells don't retreat from an aggressive to less aggressive state.

Either something in the cell culture system favored enrichment of the PN state, or most glioblastoma neurospheres exist in the less-aggressive PN state, and something in the tumor microenvironment triggers their reversible differentiation into the MES state.

Placing the
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Thomas Jefferson University Kimmel Cancer Center: Researchers Find New Clues to Treat Rare and Aggressive Inflammatory Breast Cancer
2. Study links cardiac hormone-related inflammatory pathway with tumor growth
3. Study finds dramatic increase in hospitalization of US children with inflammatory bowel disease
4. Revitol Rosacea Now Comes with Anti-Inflammatory Ingredients to Remove Redness and Flushing
5. Biomarkers discovered for inflammatory bowel disease
6. Mayo Clinic: Inflammatory bowel disease raises risk of melanoma
7. Inflammatory bowel disease detection enhanced with PET/CT
8. Revitol Rosacea Now Comes with Anti-Inflammatory Ingredients to Remove Redness and Flushing
9. Advances in Inflammatory Bowel Disease -- whats new, whats next
10. Did evolution give us inflammatory disease?
11. Manchester leads new international study investigating Inflammatory Bowl Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Europe is one of the largest ... hence, irrigated land area. The agricultural sector is a ... around 30.0% of the total water use. The scale ... southern region, but far from negligible in most northern ... over 60.0% of the water use in most countries, ...
(Date:7/11/2014)... understand the best available treatment for patients, from a ... costly for taxpayers than the existing clinical trial process, ... Staa, carried out while he was a member of ... now based at The University of Manchester,s Health eResearch ... HTA ) today (Friday 11 July) looked at the ...
(Date:7/11/2014)... Salt Lake City, UT (PRWEB) July 11, 2014 ... hard at work at the Kilimanjaro Kids Community in Tanzania. ... children, 40 goats, 150 chickens, and two cows. HOP Founder, ... and provide education for some of the orphaned children he ... week, the HOP Team visited the children, who have all ...
(Date:7/11/2014)... being prescribed exercise as medicine, according to a ... activity is essential to reducing the risk of ... from QUT,s Institute of Health and Biomedical Innovation, ... physical and mental health, health professionals should be ... Professor Anderson and QUT,s Dr Charlotte Seib co-authored ...
(Date:7/11/2014)... July 11, 2014 Emily Johnson, owner of the ... Her fitness boot camp has held two charity workout ... on Saturday, July 26th, from 7:15 - 8:30 at Col Summers ... first charity boot camp session raised $510 for Medical Teams International. ... non-profit I Have a Dream. On July 26th, Johnson and ...
Breaking Medicine News(10 mins):Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Better use of electronic health records makes clinical trials less expensive 2Health News:Human Outreach Project Sees Incredible Progress in the Kilimanjaro Kids Community 2Health News:Exercise is the best medicine: QUT study 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 3
... Council will launch its 2009 June National Safety Month with free enrollment ... , "Alive at ... "First Aid and CPR with AED," basic training ... "Alive at 25 Parent Program" is an engaging, science-based course that educates ...
... is certain: there,s no place like home. Now, a study ... is true for rats. Although inner city rodents appear to ... majority of their lives. , Like any major city, Baltimore ... But scientists from the Johns Hopkins Bloomberg School of Public ...
... staff connect using technology powered by 100 ... solutionsJERICHO, N.Y., May 26 Optimum Lightpath, ... for New York metropolitan area businesses, today ... solution available exclusively through Optimum Lightpath to ...
... the two illnesses , , TUESDAY, May 26 (HealthDay News) ... heart disease has been discovered by German scientists. , ... has been known for years, but a genetic link ... Kiel team found that the two diseases share a ...
... Scheduled for Monday June 1 at 1:00 PM ET ... Calif., May 26 Sunesis Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of new oncology therapeutics, today announced ... 2 clinical trials in frontline acute myeloid leukemia (AML) ...
... dental expert notes importance of regular oral care to protect ... Results from a 2008 Gallup-Healthways poll(1) show that 42 percent ... 12 months, even though the American Dental Association recommends having ... percent of all Americans responded that they did not see ...
Cached Medicine News:Health News:National Safety Council Launches June National Safety Month With Free Training 2Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 2Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 3Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 4Health News:Gum Disease, Heart Disease Share Genetic Link 2Health News:Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO 2Health News:Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO 3Health News:Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO 4Health News:Hispanics Placing Their Oral Health at Risk by Cutting Back on Routine Dental Care 2Health News:Hispanics Placing Their Oral Health at Risk by Cutting Back on Routine Dental Care 3
(Date:1/15/2014)... Most osteoporosis patients want a choice in the ... sponsored by Mission Pharmacal Company. The survey, conducted by ... support community, revealed that 74 percent of osteoporosis patients ... form other than a pill or a tablet. ...
(Date:1/15/2014)... 2014  Novation, the leading health care supply chain expertise, ... reseller (VAR) national contracts that expand its portfolio to ... lower costs. These include manufacturer product and service agreements, ... and ongoing IT consulting support. New ...
(Date:1/15/2014)... 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, will ... Journal of Drugs in Dermatology (JDD) at ... The event is January 17-20, 2014, at the Omni Orlando Resort ... The ODAC is a distinguished event that ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
Anodized aluminum. Durable and lightweight with built-in protection against rust. Security locks ensure against accidental opening. Silicone matting/V-strips and bumper guards hold instruments in pla...
... Storage in bottom of ... accessories, etc. Anodized aluminum. Durable ... against rust. Security locks ensure ... and bumper guards hold instruments ...
Size: 3 x 6 inches. Depth: 1 inch. Sterilizable plastic tray with silicone matting for supporting and protecting instruments....
Size: 6 x 10 inches. Depth: 7 inches. Sterilizable plastic tray with silicone matting for supporting and protecting instruments....
Medicine Products: