Navigation Links
Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
Date:7/19/2012

ANN ARBOR, Mich. Breast cancer treatments such as Herceptin that target a marker called HER2 have dramatically improved outcomes for women with this type of cancer. But nearly half of these cancers are resistant to Herceptin from the start and almost all of them will eventually become resistant.

Now, researchers at the University of Michigan Comprehensive Cancer Center have discovered one reason why the cancer cells become resistant: They turn on a completely different pathway, one that is involved in inflammation, fueling the cancer independently of HER2.

The pathway at work involves a protein called Interleukin-6, or IL-6. The researchers also showed in mice that a drug that blocks IL-6 can stop this effect and overcome the Herceptin resistance.

"Resistance to HER2-targeted therapies remains a major challenge in treating breast cancer. Our study suggests that an IL-6 inhibitor in combination with Herceptin may be a valuable addition for treating HER2-positive breast cancer," says senior study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center.

Results of the study will be published in the Aug. 24 issue of Molecular Cell.

Not only are these cells resistant to Herceptin, but they develop higher proportions of cancer stem cells, the small number of cells within a tumor that fuel the growth and spread. This makes the tumor extremely aggressive and likely to spread throughout the body. The IL-6 inhibitor also was shown to prevent this increase in cancer stem cells.

"There is evidence that patients with a lot of IL-6 tend to do poorly. What we found now is that in many of the Herceptin-resistant breast cancers, the IL-6 inflammation loop is driving the cancer stem cell," says lead study author Hasan Korkaya, D.V.M., Ph.D., research assistant professor of internal medicine at the U-M Medical School.

The researchers found that bl
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Decreasing cancer risk associated with inflammatory bowel disease
2. Discovery improves understanding of early onset inflammatory disease
3. New anti-inflammatory drugs pinch off reactive oxygen species at the source
4. New Treatments Emerging from Immune and Inflammatory Disease R&D Pipelines
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. How tumor cells create their own pathways
8. Following the genomic pathways to stop the spread of cancer
9. Discovery explains how cellular pathways converge to regulate food intake and body weight
10. Researchers block pathway to cancer cell replication
11. Grb2 holds powerful molecular signaling pathway in check
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased to ... Pharmacy Services at North Carolina State’s College of Veterinary ... Beal Award for Distinguished Volunteer Service—the organization’s highest award. ... contributions of volunteer experts to direct its work to ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the ... created for kids with cancer. The Chemo Duck App, available on ... with enjoyable games to help children of all ages living with ... to keep kids entertained, educated and at ease while waiting for ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) ... to “Live Fearless.” , The “Faces of Fearless” ... about how they or someone they know has faced a ... the moment. By telling these types of stories through livefearlessmn.com, ...
(Date:1/22/2015)... January 22, 2015 Thousand of GranuFlo ... Care recalled its GranuFlo and NaturaLyte dialysis concentrates continue ... in U.S. District Court, District of Massachusetts, Bernstein Liebhard ... the Court has remanded a case filed by the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A ... Sports Medicine flagship journal Medicine & Science in ... before exercise may help reduce gastrointestinal (GI) problems ... , Participants in the double-blind, placebo-controlled study ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... of India's most polluted rivers due to callous industries as ... , says a new study. ,A once clean ... urban towns, carrying a heavy load of pesticides released both ... fields, says the report released by Janhit Foundation., ,The ...
... University of Belgium, on Tuesday claimed that they have ... ,According to the reports, the Belgium scientists have used ... mouse-ear cress) to produce antibodies against the Hepatitis A ... drugs that are effective in fighting cancer and infections. ...
... fallen by 60% worldwide since 1999 is a major ... to halve measles deaths between 1999 and 2005 // ... in measles deaths in the African region. The progress ... the American Red Cross, the United States Centers for ...
... circumcision could reduce a man's risk of HIV infection ... Ru Xiaomei, deputy director general of China's National Population ... U.K. reports. ,Data from two studies conducted ... indicate that routine male circumcision could reduce a man's ...
... outbreak of the deadly Rift valley Fever (RVF) in neighboring ... // ,This is however despite reports that ... disease. ,Consumption of raw milk being peddled ... to be dangerous, not only due to hygienic concerns but ...
... now been discovered in India.,Sleeping sickness or Human trypanosomiases ... it is called Chagas disease. ,A farmer ... Chandrapur) 140 km from Nagpur in the central State ... confirmed case of human trypanosomiasis recorded in this country. ...
Cached Medicine News:Health News:Act Now To Cleanse Highly Polluted River Hindon, Says Study 2Health News:Global Goal to Reduce Measles Deaths in Children Surpassed 2Health News:Global Goal to Reduce Measles Deaths in Children Surpassed 3Health News:Global Goal to Reduce Measles Deaths in Children Surpassed 4Health News:Experts Warn Against Raw Milk Following Rift Valley Fever Outbreak in Kenya 2Health News:Experts Warn Against Raw Milk Following Rift Valley Fever Outbreak in Kenya 3Health News:Sleeping Sickness Comes to India 2
(Date:1/23/2015)... , Jan. 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... immune therapies for operable and inoperable solid tumor cancers, announced ... the 7 th Annual Phacilitate Immunotherapy Forum in ... at Phacilitate will take place on January 26 at 10:30 ...
(Date:1/23/2015)... 23, 2015 More than a third of reproductive-aged women ... with private insurance, filled a prescription for an opioid pain ... this week,s Morbidity and Mortality Weekly Report (MMWR). ... treat moderate to severe pain.  They are also found in ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ... directors of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... breached its fiduciary duties to shareholders. On ... investing website reporting that Advaxis had misrepresented the clinical ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
Standard reading test. 'It was the month of May'...
... Low Contrast Flip charts contain 5 pages of ... each page. Optotype size is 9.5M. Contrast levels ... flip charts can be used at several different ... same test. Each offers a different set ...
Directional `E' and `C' test....
9" X 14" translucent plastic may be used with illuminated test cabinet or as a wall chart 20/200 to 20/15....
Medicine Products: