Navigation Links
Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
Date:7/19/2012

ANN ARBOR, Mich. Breast cancer treatments such as Herceptin that target a marker called HER2 have dramatically improved outcomes for women with this type of cancer. But nearly half of these cancers are resistant to Herceptin from the start and almost all of them will eventually become resistant.

Now, researchers at the University of Michigan Comprehensive Cancer Center have discovered one reason why the cancer cells become resistant: They turn on a completely different pathway, one that is involved in inflammation, fueling the cancer independently of HER2.

The pathway at work involves a protein called Interleukin-6, or IL-6. The researchers also showed in mice that a drug that blocks IL-6 can stop this effect and overcome the Herceptin resistance.

"Resistance to HER2-targeted therapies remains a major challenge in treating breast cancer. Our study suggests that an IL-6 inhibitor in combination with Herceptin may be a valuable addition for treating HER2-positive breast cancer," says senior study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center.

Results of the study will be published in the Aug. 24 issue of Molecular Cell.

Not only are these cells resistant to Herceptin, but they develop higher proportions of cancer stem cells, the small number of cells within a tumor that fuel the growth and spread. This makes the tumor extremely aggressive and likely to spread throughout the body. The IL-6 inhibitor also was shown to prevent this increase in cancer stem cells.

"There is evidence that patients with a lot of IL-6 tend to do poorly. What we found now is that in many of the Herceptin-resistant breast cancers, the IL-6 inflammation loop is driving the cancer stem cell," says lead study author Hasan Korkaya, D.V.M., Ph.D., research assistant professor of internal medicine at the U-M Medical School.

The researchers found that bl
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Decreasing cancer risk associated with inflammatory bowel disease
2. Discovery improves understanding of early onset inflammatory disease
3. New anti-inflammatory drugs pinch off reactive oxygen species at the source
4. New Treatments Emerging from Immune and Inflammatory Disease R&D Pipelines
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. How tumor cells create their own pathways
8. Following the genomic pathways to stop the spread of cancer
9. Discovery explains how cellular pathways converge to regulate food intake and body weight
10. Researchers block pathway to cancer cell replication
11. Grb2 holds powerful molecular signaling pathway in check
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... December 25, 2014 Recently, LunaDress.co.uk has updated its ... and related accessories. Now, all of the models at LunaDress.co.uk come ... a groom lifts the wedding veil can turn out to be ... charm. A wedding veil can always bring surprise to a wedding. ... on how to choose veils for a big day . ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Overeating is common during the holidays, ... moderation, an expert says. "Don,t arrive at a party ... you know you,ll be attending a party, but deprivation leads ... dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., said ... healthy during the day and even to have a snack ...
(Date:12/25/2014)... 2014 AngelWeddingDress.com tries its best to ... realm. Today, the business has introduced its new collection ... dress promotion. , The new prom outfits are guaranteed ... dress lover. They are specially designed for 2015. Anyone ... dresses should visit its website before Jan. 26, 2015, ...
(Date:12/25/2014)... Viejo, California (PRWEB) December 25, 2014 ... release of ProFire 5k. A fully customizable business presentation ... . , “Adding the ProFire 5k business tool, users ... Said Christina Austin, CEO of Pixel Film Studios. “ProFire ... look and style to add professionalism to a presentation” ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2
... by Dr Roger Bayston in the School of Clinical Sciences, ... an allied health professional training fellowship of almost 160,000 from ... bacterial infections associated with broken bones. Pins used ... to 40 per cent of patients being treated in this ...
... NY) The American Association for Cancer Research (AACR), ... awarded Susan Band Horwitz, Ph.D. , the Rose ... molecular pharmacology at Albert Einstein College of Medicine ... Achievement in Cancer Research. Dr. Horwitz, who is ...
... 2011 Those light-emitting diodes marketed as safe, environmentally ... and a dozen other potentially hazardous substances, according to ... next generation of lighting. But as we try to ... or contribute to global warming, we have to be ...
... 10 (HealthDay News) -- People are more likely to recall an ... it is over than if they expect it to occur again, ... as equally enjoyable whether they think they,ll do them again or ... discomfort if they have a bad experience and allow them to ...
... at St. Michael,s Hospital and the Institute for Clinical and ... that will help doctors predict the probability of death in ... in the journal Circulation , found that the tool ... and one year after an ischemic stroke. An ischemic stroke, ...
... living in deprived neighbourhoods are twice as likely to have ... Coast, according to a new study by researchers at St. ... of illness and death are significantly higher in poorer neighbourhoords. ... a big role in how strongly they are affected," said ...
Cached Medicine News:Health News:Anti-bacterial collar to help mend broken bones 2Health News:Susan Band Horwitz, Ph.D., of Einstein, receives lifetime achievement award in cancer research 2Health News:Susan Band Horwitz, Ph.D., of Einstein, receives lifetime achievement award in cancer research 3Health News:LED products billed as eco-friendly contain toxic metals, study finds 2Health News:New online tool predicts probability of death from stroke 2Health News:Coastal Canadians living in high-risk neighborhoods in poorer health: Study 2
(Date:12/24/2014)... Pa. , Dec. 24, 2014  Commonwealth Cornerstone Group ... Markets Tax Credits transaction on Tuesday to help fund the ... Network (PHN) in Sharon . ... in Pennsylvania . It is the largest ... with more than 150 people on staff. Currently, ...
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., the ... the proprietary Natural Killer (NK) cell-line platform, Neukoplast® ... Patrick Soon-Shiong , NantWorks founder, physician scientist ... agreement to purchase approximately $48 million of the ... the investment, he will be named Co-Chairman of ...
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... Pharmaceuticals, Inc. (Nasdaq: PPHM ) today announced ... Group in its R&D organization. The new ... the company,s multiple external collaborations already underway or ... phosphatidylserine (PS)-targeting antibody platform for the prevention and ...
... LAKES, N.J., Oct. 7 Medco Health Solutions, Inc. (NYSE: ... find smart solutions for getting the most value out of ... Prescription Plan® has three different plan options - Choice ... in addition to providing access to a vast array of ...
Cached Medicine Technology:Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 2Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 3Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 4Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 5Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 6Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 2Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 3Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 4
Patented* Design for Endoscopic Shunt Placement. Designed to pass through standard shunt ventricular catheters for optically guided placement....
Preclude Dura Substitute is the only non-biological membrane designed to "seal" around suture holes. 0.3 mm as nominal thickness....
... Lyoplant is a new ... pericardium. A pure collagen implant, ... to three months, replacing implant ... collagen. Its natural structure minimizes ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Medicine Products: