Inflammatory mediator promotes colorectal cancer by stifling protec... ( HOUSTON

Inflammatory mediator promotes colorectal cancer by stifling protective genes

Date:1/22/2012

HOUSTON - Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine.

The team's connection of these two separate influences eventually may lead to better combination therapies for treating and preventing colorectal cancer.

In animal experiments, researchers found that prostaglandin E2, a chemical that promotes inflammation, accelerates the development of colorectal cancer by shutting down genes that suppress tumors and repair damaged DNA. They also found that while either an anti-inflammatory drug or a demethylating agent reduced the size and number of tumors in mice with colorectal cancer, the most powerful response occurred when both drugs were used together.

"We've known that chronic inflammation increases the risk of developing cancer and progression of disease," said senior author Raymond DuBois, M.D., Ph.D., provost and executive vice president at MD Anderson. "We've also known that tumor-suppressing genes are silenced in human colorectal cancer. However, nobody had made a molecular connection between these inflammatory mediators and changes in gene expression or silencing of genes through affects on DNA methylation."

Cancer prevention potential

The two drugs used in the animal experiments - the anti-inflammatory agent celecoxib (known commercially as Celebrex) and the demethylating agent azacitidine (Vidaza) - are both approved for human use.

"One potential application of our research would be a clinical trial for patients who are at extremely high risk for developing colorectal cancer, such as those with a genetic predisposition, to see if treatment with these agents would decrease their risk," DuBois said.

Prostaglandin E2 and methylation <
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. NIH grant will create behavioral health registry for pediatric inflammatory bowel disease
3. Prozac and Celexa exhibit anti-inflammatory effects
4. Physician's Pain Relief Cream Includes Patented Anti-inflammatory in New Formula
5. Feedback loop explains inflammatory effect on intestinal lining
6. Study Details Machinery of Immune Protection Against Inflammatory Diseases Like Colitis
7. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
8. New research reinforces anti-inflammatory properties of tart cherries
9. First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease
10. POP ROCK BAND Honor Society Drummer Advocates for Inflammatory Bowel Disease Patients on Capitol Hill in Conjunction with World IBD Day
11. Crohn's & Colitis Foundation National Event Helping Women Manage Inflammatory Bowel Disease: Two Women Physician Experts and Researchers in IBD on Interactive Webcast/Teleconference

Post Your Comments:

(Date:5/25/2013)... 25, 2013 According to a ... Market, 2013–2018", published by MarketsandMarkets is expected to ... of 5.54% which analyzes and studies the major ... Europe, Asia, and Rest of the World. , ... Tables , 87 Figures , ...

(Date:5/25/2013)... According to world-renowned scholars, Queen Cleopatra ... women that ever lived. Cleopatra’s legendary beauty moved nations ... most powerful men in her time. Cleopatra was also ... her skin glowing and fresh, from her legendary milk ... oil and cyprus grass. , Cleopatra was said to ...

(Date:5/25/2013)... May 25, 2013 IBISWorld estimates that revenue ... an average annual rate of 28.7% to $1.0 billion in ... 2013. From 2002 and 2008, no new cell therapy products ... relatively modest growth during that period. In the years since, ... new products. This factor contributed to the industry's fast growth ...

(Date:5/25/2013)... DF (PRWEB) May 25, 2013 Ayurveda ... sanscrit: "knowledge or wisdom of life". While a medical science, ... the transformation of consciousness. Its fundamental philosophy is that disease ... our environment. In order to re-establish optimal health, one must ... adopt a life style which brings us back into perfect ...

(Date:5/25/2013)... 2013 The current residents of Back2Basics - ... the B2B staff all came together Saturday, May 18th to ... of Indian Cuisine, the residents got up to thank Roy ... on their road to recovery, and giving them a second ... center in 2010 after realizing the need for a long-term ...

Breaking Medicine News(10 mins):Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 2 Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 3 Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 4 Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2 Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3 Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 2 Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 3 Health News:Fundamentos de Ayurveda in Mexico (Ayurvedic Principles) Offered by Escuela de Ayurveda de California 2 Health News:Back2Basics Drug and Alcohol Rehabilitation Center Celebrates Their 3rd Anniversary 2

[0] Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets [0] The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician [0] Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld [0] Fundamentos de Ayurveda in Mexico (Ayurvedic Principles) Offered by Escuela de Ayurveda de California [0] Back2Basics Drug and Alcohol Rehabilitation Center Celebrates Their 3rd Anniversary

... Holdings, Inc. (NYSE Alternext US: KUN) ("China Shenghuo" ... previous,announcements, it has filed with the United States ... Report on Form 10-KSB/A for the year,ended December ... 10-Q/A for the,first quarter ended March 31, 2008 ...

... 20 Again next year, the American Pain,Society (APS), ... programs in its acclaimed Clinical Centers of Excellence in ... until Dec. 14,2008. , ... Awards Program,honors forward-thinking teams of healthcare professionals who are ...

... volunteers from State,Farm Bayou Classic(R), organizers from KaBOOM! and residents ... 28 to build a new, safe,playground at the Abramson Science ... is based on drawings provided by,children who attended a Design ... The new playground will provide more than 400 children ...

... Contreras, 61, and Ramon Pichardo, 58, were sentenced today to ... the Medicare program in connection with a $6.8 million HIV ... the Criminal Division and U.S. Attorney R. Alexander Acosta of ... , Judge Federico A. Moreno of ...

... differ by almost $37,000 per patient, study finds , , ... treating colorectal cancer can vary by tens of thousands ... researchers compared the eight most commonly prescribed therapeutic regimens ... ambulatory care centers across the United States. , ...

... in these young adults points to danger, study finds ... the arteries of children of smokers can be detected ... Dutch study finds. , "Smoking in families is harmful ... in many other studies," said research leader Dr. Cuno ...

China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 American Pain Society Accepting Applications for Clinical Centers of Excellence in Pain Management Awards State Farm Bayou Classic and KaBOOM! Team Up to Build New Playground in Just One Day Miami Physicians Sentenced to Prison for Their Roles in a $6.8 Million Medicare Fraud Scheme Colorectal Cancer Treatment Costs Vary Widely Parent Smoking During Pregnancy Raises Kids' Heart Risks

(Date:5/24/2013)... , May 24, 2013 An international roster of ... May 18, in Santa Monica, Calif. ... lung-sparing therapies for MPM, a rare form of cancer ... the pleura, the lining of the chest. ... Blood Institute, the 3rd Annual International Symposium on Lung-Sparing ...

(Date:5/24/2013)... , May 24, 2013 China Biologic Products, ... leading fully integrated plasma-based biopharmaceutical company in ... recently learned from a public announcement issued by Shanghai ... company listed on Shenzhen Stock Exchange, that on May ... ("Ms. Chan"), one of the shareholders of the ...

(Date:5/24/2013)... -- In accordance with Rule 17.1 and Rule 2.9 of ... States Exchange Act, Echo Pharma Acquisition Limited ("Royalty Pharma") today ... ELN). Background On 2 May 2013, ... the entire of the issued and to be issued share ... On 20 May 2013, Royalty Pharma announced the ...

Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2 International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3 China Biologic Comments on the Proposed Shanghai RAAS Transaction 2 China Biologic Comments on the Proposed Shanghai RAAS Transaction 3 China Biologic Comments on the Proposed Shanghai RAAS Transaction 4 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8 Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 9

[0] International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma [0] China Biologic Comments on the Proposed Shanghai RAAS Transaction [0] Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements

... YORK, June 15, 2007 /PRNewswire/ -- Telomerase Activation,Sciences, Inc. ... Anti-Aging Trial of TA-65, the first human trial,ever to ... Activator. Statistically significant,results were found in those taking TA-65 ... -- Improvement in immune system function, ...

... Trial Presented at EULAR, BARCELONA, Spain, June ... the European League Against Rheumatism (EULAR),Annual European ... spondylitis (AS) who received REMICADE(R) (infliximab),over two ... addition, REMICADE-treated patients showed sustained,reductions in spinal ...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07,Teleconference to Answer Questions About TA-65, Their Telomerase,Activator With Proven Age Management Benefits Remicade Two Year Data in Ankylosing Spondylitis Show Improvement,in Spinal Mobility and Spinal Inflammation

... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...

... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...

... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...

... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...

Medicine Products:

NPM-ALK, t(2;5) Translocation, Quantitative by RT-PCR, Fluid Nortriptyline by HPLC Norwalk Virus Norpace