"In Crohn's disease patients, 18F-FDG PET/CT seems to accurately detect advanced inflammatory changes and also unmask subepithelial disease activity that might be missed by colonoscopy. Therefore, PET/CT might serve as an additional tool for evaluating disease activity in IBD patients, e.g., in defining complete remission," noted Bettenworth.
Michael Schfers, MD, senior author of the study, added, "Using a clinically established tracer, the translation of this approach into daily clinical routine should benefit patients in the near future and will further promote the use of PET/CT for new indications in clinical algorithms."
Crohn's disease and ulcerative colitis are chronic-remittent, inflammatory conditions featuring characteristic mucosal lesions within the bowel leading to diarrhea, stricture formation, abdominal pain and weight loss. Crohn's disease may affect as many as 700,000 Americans, and ulcerative colitis may affect up to an additional 700,000; incidence rates for these diseases are on the rise worldwide.
Authors of the article "Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation" include Dominik Bettenworth, Tobias Max Nowacki, Matthias Ross, Frank Lenze, Jan Heidemann and Andreas Lgering, Department of Medicine B, University of Mnster, Mnster, Germany; Stefan Reuter and Bayram Edemir, Department of Medicine D, University of Mnster, Mnster, Germany; Sven Hermann, European Institute for Molecular Imaging, University of Mnster, Mnster, Germany, and Department of Nuclear Medicine,
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Society of Nuclear Medicine