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Inflammatory bowel disease detection enhanced with PET/CT
Date:5/1/2013

Reston, Va. (May 1, 2013) Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, may be detected and monitored more effectively in the future with positron emission tomography/computed tomography (PET/CT), according to research published in the May issue of The Journal of Nuclear Medicine. Typically assessed by endoscopic and histologic evaluations, investigators demonstrated the ability of PET/CT to identify lesions along the complete intestinal wall that could be missed with traditional imaging techniques.

"Animal models of intestinal inflammation have contributed substantially to the current understanding of IBD; however, endoscopic examinations on the animals can be complicated, and full histological workup of the murine colon does not allow for serial assessment," said Dominik Bettenworth, MD, lead author of the study "Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation." "In this study, we evaluated 18F-FDG PET/CT as a noninvasive approach to serially assess IBD activity in small animals and confirmed its utility by analyzing PET/CT scans conducted in patients with Crohn's disease."

For the first phase of the study, researchers induced dextran sodium sulfate (DSS) colitis in mice and assessed the 18F-FDG uptake in multiple sections of the colon. Compared with control mice, an increase in 18F-FDG uptake was clearly noted in the DSS mice, with the most intensive areas of uptake in the medial and distal colon. Significant correlation was found between the PET/CT and histologic evaluations. The experiment also identified extraintestinal alterations, such as bone marrow activation, in the DSS colitis-induced mice.

Based on the results of the experiments in the colitic mice, researchers identified the extent of the mucosal damage as the parameter that correlated best to 18F-FDG uptake in the mice and in human patients with Crohn's disease. 18F-FDG PET/CT scans of 25
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Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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