Navigation Links
Inflammatory Bowel Diseases Share Some Genetic Risk Factors
Date:4/28/2008

Finding helps pinpoint relationship between Crohn's disease and colitis

MONDAY, April 28 (HealthDay News) -- The inflammatory bowel diseases ulcerative colitis and Crohn's disease appear to share several genetic variants and risk factors, two new British studies suggest.

Though similar in many ways, the two diseases are distinct, and scientists have been trying to pinpoint the underlying relationship between them to improve their understanding of and treatment for both. The latest findings, expected to be published online in the April 27 issue of Nature Genetics, may be a significant step forward.

Ulcerative colitis and Crohn's disease affect one in 250 individuals of Northern European descent. Ulcerative colitis is a common inflammatory bowel disease, while Crohn's disease is a related, but chronic disorder of the intestine.

In the first study, researchers identified ECM1, a gene variant that encodes a protein secreted by cells to activate a key immune regulator as tied to the risk of colitis. They also found that five genes previously linked to the probability of developing Crohn's disease are also common to ulcerative colitis, while three others are not.

In the second study, several of 50 previously reported susceptibility loci for Crohn's disease were deemed risk variants for both diseases. Three others were found to be specific to Crohn's disease and three specific to ulcerative colitis.

More information

The American Academy of Family Physicians has more about inflammatory bowel diseases.



-- Kevin McKeever



SOURCE: Nature Genetics, news release, April 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Elsevier announces new journal on inflammatory bowel diseases
2. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
3. C-diff infection 4 times more likely to kill patients with inflammatory bowel disease
4. Inflammatory Substance May Boost Eye Trouble
5. Mesalamine linked to cancer protection for high risk inflammatory bowel disease patients
6. Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
7. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Assessment of Its Phase I/II Trial of tgAAC94 for Inflammatory Arthritis
8. Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
9. Interactive Teleconference on Inflammatory Bowel Disease for Patients, Caregivers, and Healthcare Professionals
10. Taking more than 1 anti-inflammatory drug may lead to complications
11. Gene Linked to Inflammatory Arthritis Also Raises Heart Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: