Navigation Links
Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest
Date:7/8/2009

ST. LOUIS -- The anti-inflammatory drug indomethacin could hold promise as a treatment for Alzheimer's disease, says a Saint Louis University doctor and researcher.

Two research studies published by William A. Banks, M.D., professor of geriatrics and pharmacological and physiological science at Saint Louis University School of Medicine, support this conclusion and offer what he calls a "one-two punch" in giving clues on how Alzheimer's disease develops and could be treated.

His study in the July edition of the Journal of Alzheimer's Disease supports the idea that toxic levels of amyloid beta protein, the substance scientists believe is responsible for Alzheimer's disease, accumulate in the brain because a pump that pushes it into the blood and past the blood-brain barrier malfunctions.

The blood-brain barrier is a system of cells that regulates the exchange of substances between the brain and the blood. The blood-brain barrier transporter known as LRP is the pump that removes amyloid beta protein from the brain and into the bloodstream.

"LRP malfunctions like a stop light stuck on red, and keeps amyloid beta protein trapped in the brain," said Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis.

He tested the hypothesis by giving mice an antisense, which is a molecular compound that blocked the production of LRP. Amyloid beta protein accumulated in the brain and the mice showed memory loss and learning impairment.

The finding raises the question of what causes LRP to malfunction. Banks' study in the May issue of Brain Behavior and Immunity suggests inflammation as the culprit and supports using indomethacin, an anti-inflammatory medication, as a buffer to protect LRP from being turned off.

Inflammation, which is part of the body's natural immune response, occurs when the body activates white blood cells and produces chemicals to fight infection and invading
'/>"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
2. New Insights Show Ginseng Fights Inflammation
3. New Discovery Shows Ancient Herb Fights Inflammation
4. Man Dies of Brain Inflammation Caused by Deer Tick Virus
5. Statins may exert influence on prostate cancer growth by reducing inflammation
6. Biological FM signal maintains inflammation in cancer, asthma and other diseases
7. By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies
8. Targeting oxidized cysteine through diet could reduce inflammation and lower disease risk
9. Inflammation in colon may get doused before fueling cancer development
10. Inflammation May Play Role in Sleep Duration
11. Study suggests that inflammation may be the link between extreme sleep durations and poor health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... "We experienced difficulty filling our pill boxes ... inventors from Jamestown, Calif. "We came up with this ... could pour medications in more easily." , They created ... the lids open as the pill box is filled. ... have been filled. This eliminates hassles and frustrations, and ...
(Date:7/28/2014)... 2014 Scientists in Japan have completed ... blood test for the asbestos cancer mesothelioma. Surviving Mesothelioma ... Click here to read it now. , ... Juntendo University Graduate School of Medicine say a new ... step above the old test. , “Particularly for ...
(Date:7/28/2014)... 2014 The research found that most ... food best, with each subsequent bite being less satisfying ... actually serve to sabotage the meal. , "People ... not realizing the effect," Baba Shiv, the study's author, ... moderation, if we needed one. You actually take more ...
(Date:7/28/2014)... 2014 Labors.at, Austria’s largest and ... Healthcare Relationship Cloud™ to fuel its growth initiatives. ... to 8,000 patients daily and performs up to ... up to doubling its volume within the next ... cutting-edge 10,000 square meter facility pushed our team ...
(Date:7/28/2014)... information about the measles, mumps and rubella (MMR) vaccine ... new University of Leeds research has found. , Informing ... helping parents make a decision about MMR is on ... informing them solely via a GP consultation, and 7.17 ... vaccine. In each case, the figure comprises the cost ...
Breaking Medicine News(10 mins):Health News:Test Results Look Promising for New Mesothelioma Blood Test, According to Surviving Mesothelioma 2Health News:Large Portions Can Decrease Food Enjoyment, SlimPlate Weight Loss System Puts Focus On Portion Control 2Health News:Large Portions Can Decrease Food Enjoyment, SlimPlate Weight Loss System Puts Focus On Portion Control 3Health News:Austrian Laboratory Leader, Labors.at, Fuels Growth with the hc1® Healthcare Relationship Cloud™ 2Health News:Online information most cost-effective means of increasing MMR uptake, research finds 2
... (AMD) is the leading cause of severe visual loss ... common genetic variants which together predict a person,s increased ... without the disease also have these variants. Now, for ... show a specific rare mutation called CFH R1210C that ...
... Chapel Hill, NC In a study published today ... of scientists including UNC biologist Jason Lieb, PhD, present ... can survive with only one copy of the X ... topic in science and provides biologists with more information ...
... EAE President Doctor Luigi Badano, FESC, from the University ... we need to acquire information from all the different ... the ESC, the EAE,s philosophy is that we want ... oriented, so that we,re using the most appropriate technology ...
... Imagine having skin so supple you could stretch it out ... - repeatedly - yet it would always snap back completely ... never need Botox. That enviable elasticity is one of ... sensor that is the latest sensor developed by Stanford,s Zhenan ...
... 23 (HealthDay News) -- Gaining a significant amount of ... risk of developing endometrial cancer, a new study suggests. ... circulating estrogen in postmenopausal women, and estrogen promotes the ... of laboratory services at the National Home Office of ...
... Fla. October 24, 2011 A new analysis of recent eye ... to reduced rates of nearsightedness, also known as myopia, in ... the United States and many other countries than it was ... percent of the population is nearsighted. The analysis suggests that ...
Cached Medicine News:Health News:Researchers ID genetic mutation associated with high risk of age-related macular degeneration 2Health News:Study confirms males and females have at least 1 thing in common: Upregulating X 2Health News:Congress alert: EUROECHO and Other Imaging Modalities: New patient emphasis 2Health News:Congress alert: EUROECHO and Other Imaging Modalities: New patient emphasis 3Health News:Stanford researchers build transparent, super-stretchy skin-like sensor 2Health News:Stanford researchers build transparent, super-stretchy skin-like sensor 3Health News:Weight Gain Might Raise Endometrial Cancer Risk 2Health News:More time outdoors may reduce kids' risk for nearsightedness 2
(Date:7/25/2014)...  Corporate libraries are constantly being faced with a ... and how to cope with flat or shrinking budgets. ... medical device industries are increasingly finding it challenging to ... provide. According to recent research by ... of change that leading corporate libraries are being faced ...
(Date:7/25/2014)... Calif. , July 25, 2014  Depomed, Inc. ... will release second quarter fiscal year 2014 financial results ... Company will host a conference call beginning at 4:30 ... Participants can access the call by dialing 877-317-6789 ( ... conference call will also be available via a live ...
(Date:7/25/2014)... Calif. , July 25, 2014 /PRNewswire-iReach/ -- ... Nieto as the new Vice President of Business ... over 30 years in a number of different business ... the industry. These positions were primarily related to business ... over the past 30 years makes him a key ...
Breaking Medicine Technology:Forces of Change Reshaping Corporate Libraries & Information Services 2Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2Contract Research Organization WCCT Global Welcomes Peter Nieto as Vice President of Business Development 2
... Misonix, Inc. (NASDAQ: MSON ), ... markets innovative therapeutic ultrasonic products worldwide for wound ... and other surgical and medical applications, has entered ... Osteotrauma Ltda., based in Concepcion, Chile. Osteotrauma will ...
... 1, 2011 /PRNewswire-USNewswire/ – CoMeD – On ... Programme (UNEP) distributed a revised text for ... mercury-free drugs were gratified to see pharmaceuticals listed in ... treaty. The Coalition for Mercury-free Drugs ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement for Chile 2Misonix Announces New Distribution Agreement for Chile 3Global Mercury Treaty May Include Ban on Mercury in Medicine 2Global Mercury Treaty May Include Ban on Mercury in Medicine 3
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of cardiac troponin I (cTnl) in human whole blood and serum specimens...
Medicine Products: