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Inflammation in prostate may reduce cancer risk
Date:12/9/2013

MANHASSET, NY Doctors at the North Shore-LIJ Health System have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer. The findings are published online in CANCER.

Prostate cancer is one of the most common cancers in men, with an estimated 240,000 new cases diagnosed every year it kills approximately 30,000 men annually. The prostate is a small gland that produces fluid that nourishes and transports sperm. When the cancer is detected early while still confined to the prostate gland, there is a much better chance of successful treatment according to the American Cancer Society, a five-year relative survival rate is 100 percent when prostate cancer is detected early and there is no sign that the cancer has spread outside of the prostate.

Previous studies have found that chronic inflammation contributes to several forms of cancer an estimated 20 percent of adult cancers can be attributed to chronic inflammatory conditions. To evaluate if inflammation in the prostate increases the risk of cancer in the gland, Daniel Moreira, MD, a urologist at the North Shore-LIJ Health System, and his colleagues conducted a clinical trial.

They conducted a retrospective analysis of the REduction by DUtasteride of PCa Events (REDUCE) trial, including 6,238 men ages 50 to 75 who had increased prostate inflammation with a negative biopsy (no cancer). They then underwent two more biopsies one at two years and another at four years. At both two- and four-year intervals, the doctors found that those participating in the study who had higher levels of prostate inflammation also had a lower risk of prostate cancer. These findings show that biopsies in prostates that are free of cancer and have high inflammation may indicate a lower risk for getting prostate cancer in the future.

"Because we have shown that inflammation has a predictive value, it should be routinely evaluated in prostate biopsi
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Contact: Emily Ng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

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