Navigation Links
Inflammation contributes to colon cancer
Date:1/21/2009

Researchers led by Drs. Lillian Maggio-Price and Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer. They report these findings in the January 2009 issue of The American Journal of Pathology.

Bacteria contribute to the development of certain cancers, in some measure, by stimulating chronic inflammation. Absence of a molecule that inhibits inflammation, Smad3, may therefore increase susceptibility to colon cancer.

To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice deficient in Smad3 that lack of adaptive immune responses. They found that these mice are acutely sensitive to bacterially-induced inflammation and cancer due to both deficient T regulatory cell function and increased expression of proinflammatory cytokines. Through increased expression of both pro-oncogenic and anti-apoptotic proteins, epithelial cells in colonic tissues underwent both enhanced proliferation and survival.

"That the inflammatory response to microorganisms is a key event in these results reveals important 'tumor-suppressive' functions for Smad3 in T effector cells, T regulatory cells, and intestinal epithelial cells, all of which may normally limit the development of colon cancer in response to bacterial inflammation," explains the groups led by Dr. Maggio-Price and Dr. Iritani.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related medicine news :

1. Control of Inflammation May Benefit Many of the Most Feared Illnesses in Middle and Old Age
2. Inflammation Markers May Help Predict Stroke Risk
3. Lung cancer cells activate inflammation to induce metastasis
4. Inflammation: Connecting the Mouth and Body?
5. Pelvic Inflammation Puts Girls at Risk for Repeat STIs
6. The Results From a Clinical Trial Led by the Montreal Heart Institute Demonstrate That Drug Reduces Inflammation in Patients With Serious Cardiovascular Disease
7. Researchers describe how chronic inflammation can lead to stomach cancer
8. Latest Pistachio Study Reveals Significant Reduction in Markers of Inflammation - an Emerging Risk Factor in Heart Disease
9. Fatness Boosts Inflammation in Body
10. Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
11. Loss of sleep, even for a single night, increases inflammation in the body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... ... Super Bowl 50 will emanate from Levi’s Stadium in Santa Clara, CA on ... Super Bowl. In the two weeks that separate the conference championships and the Super Bowl, ... Bowl game will mark the 50th time it has been held and the festivities will ...
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New ... It was also the first provider of Exilis non-surgical fat reduction in New ... procedures it has attracted a large International clientele. Many patients travel to New ...
(Date:7/31/2015)... VA (PRWEB) , ... July 31, 2015 , ... ... introduced its new store run by GoodThreads. The store can be accessed by ... and designs, many of which are customizable. The best part: whenever a product ...
(Date:7/31/2015)... ... July 31, 2015 , ... Sculpted Contours Luxury Medical Aesthetics announces the arrival ... Zeltiq Aesthetics released this new applicator in the United States as an upgrade to ... thighs. The original applicator required a 2 hour treatment time. The new ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug and ... True North Conference Center. The medical community, social workers, law enforcement, and government ... more aligned in the effort to better understand and combat sex trafficking. Lead ...
Breaking Medicine News(10 mins):Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... WLP ) announced today that it has reached ... the manner in which out-of-network reimbursement to providers will ... the Attorney General, WellPoint has agreed to discontinue the ... determining out-of-network reimbursement for certain products and in certain ...
... leading provider of clinical services and trial management ... veterans to support the expansion of its global ... Bromley, PhD, have joined ePharmaSolutions, clinical team to ... technologies that support the training, certification and ongoing ...
... Reduces Medicare Claims Denials by 50% and IVANS LIME Is Ten ... ... February 18, 2009 -- IVANS , the leading provider of ... Eligibility Verification solution has helped Mobile X-Ray Imaging Inc. significantly ...
... Red Cross asks you to help save lives by ... drive is being held on Saturday, February 21, 2009 ... Ellie Koerner of Sewell, New Jersey. To make ... 1-800-GIVE-LIFE (1-800-448-3543). (Logo: http://www.newscom.com/cgi-bin/prnh/20081216/DC52619LOGO )Koerner is battling ...
... . , A team of specialists at the ... variants that have greater resistance to a specific treatment and ... patients affected by osteosarcoma. The team investigated the mechanisms of ... in the future. , In concrete, the research focused on ...
... Pasadena, CAFebruary 18, 2009"Suicide by Cop" (SBC) is a suicide ... danger to others in an attempt to get oneself killed ... Journal of Forensic Sciences examined the prevalence of ... , Results show that SBC occurs at extremely high rates, ...
Cached Medicine News:Health News:WellPoint Joins New York Attorney General in Creation of New Independent Database for Out-of-Network Reimbursement 2Health News:ePharmaSolutions Adds Several Industry Clinicians to its Rater Certification and Data Monitoring Department 2Health News:IVANS Helps Mobile X-Ray Imaging Inc. Reduce Its Costs for Uncompensated Care 2Health News:IVANS Helps Mobile X-Ray Imaging Inc. Reduce Its Costs for Uncompensated Care 3Health News:Blood Drive Held in Honor of Sewell, NJ Resident - Ellie Koerner 2Health News:Research increases possibilities of personalizing treatment of infant osteosarcoma 2Health News:Research increases possibilities of personalizing treatment of infant osteosarcoma 3Health News:'Suicide by cop' phenomenon occurring in over a third of North American shootings involving police 2
(Date:7/30/2015)...  Today we bring you a special edition of #MedicareMonday on Medicare,s 50 th ... of our Medicare resources and continue highlighting the success of the prescription drug benefit, ... Check out our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... July 30, 2015 PTC Therapeutics, Inc. (NASDAQ: ... reported financial results for the second quarter ending June ... many fronts across the organization.  We are excited to ... dystrophy clinical trial ever conducted with topline results expected ... Chief Executive Officer, PTC Therapeutics, Inc. "Translarna is now ...
(Date:7/30/2015)... 30, 2015 Eisai Inc. announced today that ... United States , European Union and ... respectively) for eribulin, for the treatment of patients with ... chemotherapy for advanced or metastatic disease. ... pivotal global Phase 3 clinical trial (Study 309), which ...
Breaking Medicine Technology:Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5
... biopharmaceutical company at the forefront of immunology treatment and research, ... in Washington, D.C. by reinforcing its commitment to improving the ... meeting, a large body of UCB data will highlight the ... severe Crohn,s disease. "ACG is an opportunity for ...
... MILPITAS, Calif., Oct. 28, 2011 LifeScan, Inc., the maker ... with Rite Aid to launch the Rite Track ... of American Diabetes Month, a mobile bus will travel to ... to provide complimentary on-site blood glucose and A1c testing, educational ...
Cached Medicine Technology:UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 2UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 3Celebrity Chef Sam Talbot Gets on Board for Diabetes Testing 2Celebrity Chef Sam Talbot Gets on Board for Diabetes Testing 3Celebrity Chef Sam Talbot Gets on Board for Diabetes Testing 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: