Navigation Links
Inflammation contributes to colon cancer
Date:1/21/2009

Researchers led by Drs. Lillian Maggio-Price and Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer. They report these findings in the January 2009 issue of The American Journal of Pathology.

Bacteria contribute to the development of certain cancers, in some measure, by stimulating chronic inflammation. Absence of a molecule that inhibits inflammation, Smad3, may therefore increase susceptibility to colon cancer.

To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice deficient in Smad3 that lack of adaptive immune responses. They found that these mice are acutely sensitive to bacterially-induced inflammation and cancer due to both deficient T regulatory cell function and increased expression of proinflammatory cytokines. Through increased expression of both pro-oncogenic and anti-apoptotic proteins, epithelial cells in colonic tissues underwent both enhanced proliferation and survival.

"That the inflammatory response to microorganisms is a key event in these results reveals important 'tumor-suppressive' functions for Smad3 in T effector cells, T regulatory cells, and intestinal epithelial cells, all of which may normally limit the development of colon cancer in response to bacterial inflammation," explains the groups led by Dr. Maggio-Price and Dr. Iritani.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related medicine news :

1. Control of Inflammation May Benefit Many of the Most Feared Illnesses in Middle and Old Age
2. Inflammation Markers May Help Predict Stroke Risk
3. Lung cancer cells activate inflammation to induce metastasis
4. Inflammation: Connecting the Mouth and Body?
5. Pelvic Inflammation Puts Girls at Risk for Repeat STIs
6. The Results From a Clinical Trial Led by the Montreal Heart Institute Demonstrate That Drug Reduces Inflammation in Patients With Serious Cardiovascular Disease
7. Researchers describe how chronic inflammation can lead to stomach cancer
8. Latest Pistachio Study Reveals Significant Reduction in Markers of Inflammation - an Emerging Risk Factor in Heart Disease
9. Fatness Boosts Inflammation in Body
10. Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
11. Loss of sleep, even for a single night, increases inflammation in the body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Researchers have pinpointed the environmental source of fungal infections ... for decades. It literally grows on trees. , The ... 13-year-old girl, who spent the summer gathering soil and ... by infections of the fungus named Cryptococcus gattii ... which encompasses a number of species including C. ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- Black mothers are ... and here,s one possible reason why: Hospitals in neighborhoods ... than those in areas with more white residents, a ... breast-feeding are much less common in medical centers where ... the U.S. Centers for Disease Control and Prevention reported ...
(Date:8/21/2014)... seniors, dimming vision may be tied to poorer survival, new ... aged 65 to 84, who were assessed when they enrolled ... later. Vision loss over time was associated with an ... period, the researchers reported. Although the study couldn,t prove ... University in West Lafayette, Ind., offered up some theories on ...
(Date:8/21/2014)... New York (PRWEB) August 21, 2014 ... against C.R. Bard, Inc. continue to move forward ... District Court, Southern District of West Virginia, Bernstein ... issued on August 14th, the Court has established ... that requires special handling, division, storage and preservation. ...
(Date:8/21/2014)... woman is to focus on her body in terms ... viewing her as a complete human being with thoughts ... problem in the media, how does it affect individual ... Women Quarterly , a SAGE journal, finds that more ... higher incidents of sexual pressure and coercion., Researchers Laura ...
Breaking Medicine News(10 mins):Health News:Fungus deadly to AIDS patients found to grow on trees 2Health News:Racial Disparities in Breast-Feeding May Start With Hospitals, Study Suggests 2Health News:Failing Vision Tied to Shorter Lifespans for Seniors 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:Objectification in romantic relationships related to sexual pressure and coercion 2
... oldest and largest,consumer organization dedicated to preventing vaccine ... announced today that it,will launch a national public ... informed, voluntary decisions about vaccination in America., ... of vaccines recommended by,federal officials for children during ...
... twice as likely to suffer major trauma; more education, ... -- Knee injuries are the most common reason for ... on nine high school sports at 100 U.S. high ... basketball, baseball and wrestling, and girls, soccer, volleyball, basketball ...
... Medicare premiums have doubled since 2000, AUSTIN, ... AARP members and volunteers today delivered more than,20,000 ... Hutchison and John,Cornyn in Dallas and Austin, saying ... increases., (Logo: http://www.newscom.com/cgi-bin/prnh/20030514/AARPLOGO ), ...
... Outreach, LAKE SUCCESS, N.Y., May 29 IPRO, ... the quality,of health care, announced today that it has ... on Google will link users,with IPRO,s consumer-directed sites., ... help us,enormously in our efforts to make health care ...
... Condensing the sum of oncology know-how presented at ... Conference presents a great opportunity to benefit from ... in oncology presented by renowned professionals in the ... continuing medical education, professional development and clinical experience ...
... The Little Clinic, CINCINNATI and NASHVILLE, Tenn., May ... The Little Clinic LLC today announced a,partnership aimed at ... across the country. Kroger has made a significant,investment in ... Financial terms of the investment were not disclosed. The ...
Cached Medicine News:Health News:NVIC Launches 'Stand Up Be Counted Campaign' to Protect Voluntary Vaccination Decisions in America 2Health News:NVIC Launches 'Stand Up Be Counted Campaign' to Protect Voluntary Vaccination Decisions in America 3Health News:Knee Injuries Main Cause of HS Sports Surgeries 2Health News:AARP Protests Medicare Premium Increases, Delivering Over 20,000 Petitions to Senators Hutchison and Cornyn 2Health News:AARP Protests Medicare Premium Increases, Delivering Over 20,000 Petitions to Senators Hutchison and Cornyn 3Health News:IPRO Receives Google Advertising Grant 2Health News:ESMO Conference Lugano 2Health News:Kroger and The Little Clinic Establish Partnership to Offer Customers Convenient Healthcare Centers Inside Their Neighborhood Store 2Health News:Kroger and The Little Clinic Establish Partnership to Offer Customers Convenient Healthcare Centers Inside Their Neighborhood Store 3
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... of COPD,  physicians in Brazil ... to follow clinical guidelines and commonly prescribe long-acting ... regimens, although they do so within current severe ... combinations (FDCs) that are expected to launch in ...
(Date:8/21/2014)... , N.Y. and HAMBURG, Germany , Aug. ... it is collaborating with Deutsches Elektronen-Synchrotron ( DESY ), ... , to speed up management and storage of ... Data and Analytics architecture based on IBM software ... second of data at peak performance and help scientists ...
(Date:8/21/2014)... percent of Americans believe the abuse of strong prescription pain ... safety issue in the United States , ... & Partners, a Cincinnati based research ... the prescription medication abuse problem and the need for medical ... facing our country," Rex Repass , CEO of the ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... ASHBURN, Va., Dec. 18 Innocoll, Inc., ... first of three planned,phase 2 clinical trials ... Ltd, to investigate CollaRx(R) GENTAMICIN TOPICAL for ... ulcers, has commenced,dosing., CollaRx GENTAMICIN TOPICAL ...
... RICHMOND, Va., Dec. 18 Insmed Inc. (Nasdaq:,INSM), ... that the Food and Drug Administration (FDA) has ... of Myotonic Muscular,Dystrophy (MMD). Insmed is currently conducting ... MMD, and recently was awarded a grant of,approximately ...
Cached Medicine Technology:Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) GENTAMICIN TOPICAL for the Treatment of Mildly Infected Diabetic Foot Ulcers 2Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) GENTAMICIN TOPICAL for the Treatment of Mildly Infected Diabetic Foot Ulcers 3Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) GENTAMICIN TOPICAL for the Treatment of Mildly Infected Diabetic Foot Ulcers 4Insmed Receives FDA Orphan Drug Designation for IPLEX(TM) in the Treatment of Myotonic Muscular Dystrophy 2Insmed Receives FDA Orphan Drug Designation for IPLEX(TM) in the Treatment of Myotonic Muscular Dystrophy 3
... The Carriazo-Pendular microkeratome is based on ... the cornea during the cut., ,This ... evenly from the beginning of the ... that the intraocular pressure does not ...
... somatomedin-C, is a peptide highly dependent on ... activity. IGF-I is transported in serum by ... growth disorders, measurements of IGF-I are a ... secretion. A normal plasma or serum IGF-I ...
... The IDS OCTEIATM IGF-I kit is a ... Insulin-like Growth Factor-I (IGF-I) in serum or ... polyclonal "capture" antibody in microtiter wells and ... horseradish peroxidase. A simple sample pre-treatment replaces ...
Inquire...
Medicine Products: