Navigation Links
Inflammation Might Play Role in Heart Disease: Study
Date:3/14/2012

WEDNESDAY, March 14 (HealthDay News) -- A protein involved in inflammation appears to play a role in the development of coronary heart disease, new research indicates.

Coronary heart disease -- also known as hardening of the arteries -- is caused by plaque build-up in the small vessels that supply blood and oxygen to the heart.

The new findings suggest that drugs that target the protein interleukin-6 receptor (IL6R) in the body might help prevent coronary heart disease. One such drug, tocilizumab, is currently used to treat rheumatoid arthritis.

The articles appeared online March 13 in The Lancet.

In one analysis, researchers reviewed data from more than 200,000 people in 82 studies and found that those with a genetic variation of IL6R that dampens inflammation had a reduced risk of heart disease.

For each inherited copy of the genetic variation Asp358Ala, a person had a 3.4 percent reduced risk of coronary heart disease.

"These results support the inflammation hypothesis in coronary heart disease and encourage exploration of modulation of IL6R pathways as a means to prevent coronary heart disease," wrote researchers from the IL6R Genetics Consortium and Emerging Risk Factors Collaboration.

In the second analysis, researchers reviewed data from more than 133,000 people in 40 studies and found a 5 percent reduced risk of coronary heart disease for each inherited copy of the Asp358Ala variant.

"IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomized trials," wrote the researchers with the IL6R Mendelian Randomization Analysis Consortium.

"Collectively, these large-scale and highly consistent results lend strong support to the concept that inhibition of inflammatory pathways is an attractive strategy to reduce cardiovascular risk," Matthijs Boekholdt and Erik Stroes, from the Academic Medical Center in Amsterdam, Netherlands, wrote in an accompanying editorial.

More information

The U.S. National Heart, Lung, and Blood Institute has more about coronary heart disease.

-- Robert Preidt

SOURCE: The Lancet, news release, March 12, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New class of compounds stops disease-fueling inflammation in lab tests
2. The balancing act between protection and inflammation in MS
3. NIH grant targets inflammation in link between obesity and disease
4. UIC researchers discover how cells limit inflammation in lung injury
5. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
6. Major cause of chronic kidney disease-related inflammation is identified
7. Titanium Joint Debris May Trigger Painful Inflammation
8. Ginger Supplements Might Ease Inflammation Linked to Colon Cancer
9. Imaging agents offer new view of inflammation, cancer
10. T cells making brain chemicals may lead to better treatments for inflammation, autoimmune diseases
11. Inflammation From Rheumatoid Arthritis Tied to Heart Disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inflammation Might Play Role in Heart Disease: Study
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... **An FDAnews Management Report**, http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world of ... can get while staying in compliance with FDA rules. , The FDA has ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... LVS 7510 at the Global GS1 Healthcare Conference 2017 in Chicago, IL on ... industry for ensuring label quality and improving patient safety. , Microscan ...
(Date:9/21/2017)... , ... September 21, 2017 , ... FlipBelt, the fitness ... attention to detail to the athletic wear market with the launch of their FlipBelt ... can have their essentials securely at their fingertips while at the gym, on the ...
(Date:9/20/2017)... ... 20, 2017 , ... FirstAlign ( http://www.firstalign.com ), combines strategies ... Intelligence (AI) thinking, announced today the launch of its revamped web presence. ... that offers a more comprehensive understanding of the organization’s business and machine learning ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released a ... activities. , FDA is more adamant than ever about medical device, pharmaceutical, ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... 2017  Explorers Like Us ( https://explorerslikeus.com/ ) is embarking ... — and deliver these experiences as part of Life Environments™, ... and heal better. ... While nothing beats a walk, jog or simply playing ... Environments™ is the next best thing when getting there isn’t ...
(Date:8/29/2017)... , Aug. 29, 2017 ivWatch, LLC, the leading ... IV infiltrations, announced it has been awarded an Innovative Technology contract ... in the country. ... monitoring device to aid in the early detection of peripheral IV ... The Innovative Technology ...
(Date:8/28/2017)... , Aug. 28, 2017   Aesculight ®, a division of ... surgical lasers. Built on over 20 years of American veterinary laser ... New and Exclusive VetScalpel®Features and Enhancements ... Duclos, DVM, is excising a tumor with his new VetScalpel laser. Dr. ... Lynnwood, WA. ...
Breaking Medicine Technology: