Navigation Links
Inflammation Markers May Help Predict Stroke Risk
Date:1/8/2009

They should be used when assessing traditional risk factors, experts say

THURSDAY, Jan. 8 (HealthDay News) -- Two molecular signs -- or "biomarkers" -- of inflammation may provide useful information when trying to assess a person's risk of stroke, new research says.

"If you are very high or very low risk, adding these markers does not change things much," said study lead author Dr. Vijay Nambi, a cardiologist at the Methodist DeBakey Heart & Vascular Center and Baylor College of Medicine in Houston. "But if we are not sure if you are at high risk or low risk, they can provide you with more information."

The markers in question are C-reactive protein (CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2). Both are indicators of inflammation, and both -- especially CRP -- have been well studied as potential predictors of cardiovascular conditions such as heart attack and stroke.

A first assessment of the risk of stroke must start with the well-known risk factors, such as high blood pressure, high cholesterol, obesity, diabetes and lack of physical activity, Nambi said.

In the new report on the long-running Atherosclerosis Risk in Communities (ARIC) study, those risk factors were used to describe 12,762 participants as having a low risk of stroke (less than 2 percent) within the next five years, intermediate risk (2 percent to 5 percent), or high risk (greater than 5 percent) within five years.

Tests for the two biomarkers reclassified 4 percent, 39 percent, and 34 percent of the low-, intermediate- and high-risk categories, respectively.

In all, 4 percent of the individuals were reclassified from the low- to the intermediate-risk group; 10.7 percent and 27.9 percent were reclassified from the intermediate-risk to the high- and low-risk groups, respectively; and 33 percent of the individuals classified as high risk were reclassified to the intermediate-risk group. No individuals were reclassified from the low- to the high-risk group. Reclassification was most frequent in the intermediate-risk group, the study found.

The findings are published in the February issue of the journal Stroke.

The findings don't prove the value of testing for inflammation biomarkers, Nambi said, adding, "They need to be looked at in different populations" of people.

But the study seems to support an American Heart Association recommendation that a CRP test isn't recommended for someone at low risk of stroke, which the association defines as less than 10 percent within 10 years. CPR tests are recommended, however, for individuals at intermediate risk -- 20 percent within 10 years.

And once the classification has been made, the biomarkers aren't the target of preventive measures, Nambi said. The real targets should be lowering blood pressure, keeping blood cholesterol at safe levels, avoiding obesity, and increasing physical activity, he said.

"Blood pressure has a lot more effect on stroke, compared to its role in heart disease," Nambi said. "Cholesterol is of more importance for heart disease."

Dr. Philip Gorelick, director of the Center for Stroke Research at the University of Illinois College of Medicine at Chicago, said "patients who are concerned about the risk of stroke or have risk factors for stroke should have these tests [for inflammation] done."

Adding the two inflammation biomarkers to conventional risk factors "should help determine how aggressively you treat the conventional risk factors, for example, how low you drive down cholesterol levels," he said.

More information

Learn more about CRP's role in heart disease and stroke at the American Heart Association.



SOURCES: Vijay Nambi, M.D., cardiologist, Methodist DeBakey Heart & Vascular Center and Baylor College of Medicine, Houston; Philip Gorelick, M.D., M.P.H., FACP, director, Center for Stroke Research, University of Illinois College of Medicine at Chicago; February 2009, Stroke


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. New insights into inflammation in osteoarthritis
3. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
4. Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
5. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
6. Inflammation Cant Explain Depressions Link to Heart Disease
7. UC Davis researchers discover novel pathway to increased inflammation in diabetes patients
8. Exercise may play role in reducing inflammation in damaged skin tissue
9. Researchers develop powerful tool to study the genetics of inflammation
10. Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome
11. Diabetes Linked to Blood Vessel Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 24, 2017 , ... Accordant Technology, a trusted IT solutions ... an analytics-first approach, layered with machine learning, that provides real-time visibility into the ... cloud to the edge. Through the new partnership, customers get the real-time situational ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., ... the food and beverage industry offers Citri-Fi®, a natural citrus fiber, to improve ... decision process. As a result, labels need to deliver simple, transparent and clear ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Allegheny Health ... open The Alexis Joy D’Achille Center for Women’s Behavioral Health at West Penn ... in western Pennsylvania for women suffering from pregnancy-related depression. Construction of the Center ...
(Date:5/23/2017)... , ... May 23, 2017 , ... ... body for exercise professionals, is pleased to announce the organization’s Certified Strength Coach ... The NCSF Certified Strength Coach (CSC) program validates the competency of qualified candidates ...
(Date:5/23/2017)... York (PRWEB) , ... May 23, 2017 , ... ... LifeLabs, a leading equipment provider in the modern ART laboratory, to provide hands-on ... in Ft. Lauderdale, Florida. , NextGen LifeLabs, a MedTech Group Purchasing vendor ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Bayer announced today that the latest research from ... the 53 rd Annual Meeting of the American ... in Chicago . ... liver and thyroid cancers, as well as lymphomas, and ... trial of copanlisib in patients with relapsed or refractory ...
(Date:5/11/2017)... , May 11, 2017  Thornhill Research ... has been awarded an $8,049,024 USD five-year, firm-fixed-priced, ... through the Canadian Commercial Corporation (CCC) ( ... Anesthesia Systems to administer general anesthesia to patients ... "The US Marine Corps have been ...
(Date:5/10/2017)... May 10, 2017 Radiology has become the ... costs have also spiraled to the number one ranking ... radiology than ever before as the most complete and ... patient with lower back pain an MRI may confirm ... for pain, resulting in entirely different treatment protocols.  In ...
Breaking Medicine Technology: