Navigation Links
Inflammation Can't Explain Depression's Link to Heart Disease
Date:11/15/2007

Other factors must be at play to raise women's risk, researchers say

THURSDAY, Nov. 15 (HealthDay News) -- Depression is known to hike the risk of cardiovascular disease, but don't put all the blame on any concurrent rise in inflammation.

So concludes a study led by Dr. Viola Vaccarino, a professor of medicine at Emory University, in Atlanta.

That means that it's back to the drawing board in terms of unraveling the depression-heart disease link, according to Vaccarino.

"That depression is a factor in cardiovascular disease is clear. What is not clear is what kind of mechanism is involved," she said.

The Emory group, as well as researchers from five other medical institutions, studied the possible role of inflammation in a group of 559 women who were referred for heart tests because of blockage in a coronary artery. All the women had a standard test for depression at the start of the study and were followed for an average of about six years.

They were divided into three groups on the basis of those tests: those who clearly were depressed by diagnosis and previous treatment; those who might be depressed because of either a diagnosis or treatment; and those who had no indicator of depression.

The researchers made frequent measurements of two molecules linked to the inflammatory response -- C-reactive protein (CRP) and interleukin-6.

There were 79 major events of cardiovascular disease during the study, 23 of them fatal.

As expected, the incidence of such events was 2.5 times higher in women with depression. There was no comparable increase in women classified as possibly depressed.

The team found that women diagnosed as depressed had a 70 percent higher level of C-reactive protein and a 25 percent higher level of interleukin-6 compared to women who were not depressed. Women classified as possibly depressed had elevated levels of both markers, but to a lesser extent.

The bottom line, according to the researchers, was that while inflammation was tied to heart risk, it failed to explain most of the cardiovascular danger posed by depression.

"Despite being associated with each other, depression and inflammation predicted future events for the large part independently," the researchers wrote. "Thus, despite a clear relationship between depression and inflammation, the latter plays only a minor role in the higher risk of adverse outcomes for women with depression."

The finding is something of as surprise, said Dr. David S. Sheps, professor of medicine at the University of Florida at Gainesville, a member of the research team.

"We know from other studies that there is a relationship between depression and elevation of certain inflammatory molecules, but no one knows for sure what the mechanism is," Sheps said.

"What is clear is that inflammation does not play a substantial role," Vaccarino said. "We need to look at other things. Perhaps there is a change in the ability of platelets to aggregate." Platelets are blood cells that can form clots to block arteries. "And there could be other pathways," she said.

More information

There's more on C-reactive protein and heart disease at the American Heart Association.



SOURCES: Viola Vaccarino, M.D., Ph.D., professor, medicine, Emory University, Atlanta; David S. Sheps, M.D., professor, medicine, University of Florida, Gainesville; November 2007 Journal of the American College of Cardiology


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. New insights into inflammation in osteoarthritis
3. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
4. Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
5. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
6. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
7. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
8. Elliott Extremely Dissatisfied With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company
9. Study shows adverse drug events reported to the FDA have significantly increased
10. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
11. Ericom Provides Significant Cost-Savings for Major New York City Healthcare Organization
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inflammation Can't Explain Depression's Link to Heart Disease
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
Breaking Medicine Technology: