Navigation Links
Inflammation Can't Explain Depression's Link to Heart Disease

Other factors must be at play to raise women's risk, researchers say

THURSDAY, Nov. 15 (HealthDay News) -- Depression is known to hike the risk of cardiovascular disease, but don't put all the blame on any concurrent rise in inflammation.

So concludes a study led by Dr. Viola Vaccarino, a professor of medicine at Emory University, in Atlanta.

That means that it's back to the drawing board in terms of unraveling the depression-heart disease link, according to Vaccarino.

"That depression is a factor in cardiovascular disease is clear. What is not clear is what kind of mechanism is involved," she said.

The Emory group, as well as researchers from five other medical institutions, studied the possible role of inflammation in a group of 559 women who were referred for heart tests because of blockage in a coronary artery. All the women had a standard test for depression at the start of the study and were followed for an average of about six years.

They were divided into three groups on the basis of those tests: those who clearly were depressed by diagnosis and previous treatment; those who might be depressed because of either a diagnosis or treatment; and those who had no indicator of depression.

The researchers made frequent measurements of two molecules linked to the inflammatory response -- C-reactive protein (CRP) and interleukin-6.

There were 79 major events of cardiovascular disease during the study, 23 of them fatal.

As expected, the incidence of such events was 2.5 times higher in women with depression. There was no comparable increase in women classified as possibly depressed.

The team found that women diagnosed as depressed had a 70 percent higher level of C-reactive protein and a 25 percent higher level of interleukin-6 compared to women who were not depressed. Women classified as possibly depressed had elevated levels of both markers, but to a lesser extent.

The bottom line, according to the researchers, was that while inflammation was tied to heart risk, it failed to explain most of the cardiovascular danger posed by depression.

"Despite being associated with each other, depression and inflammation predicted future events for the large part independently," the researchers wrote. "Thus, despite a clear relationship between depression and inflammation, the latter plays only a minor role in the higher risk of adverse outcomes for women with depression."

The finding is something of as surprise, said Dr. David S. Sheps, professor of medicine at the University of Florida at Gainesville, a member of the research team.

"We know from other studies that there is a relationship between depression and elevation of certain inflammatory molecules, but no one knows for sure what the mechanism is," Sheps said.

"What is clear is that inflammation does not play a substantial role," Vaccarino said. "We need to look at other things. Perhaps there is a change in the ability of platelets to aggregate." Platelets are blood cells that can form clots to block arteries. "And there could be other pathways," she said.

More information

There's more on C-reactive protein and heart disease at the American Heart Association.

SOURCES: Viola Vaccarino, M.D., Ph.D., professor, medicine, Emory University, Atlanta; David S. Sheps, M.D., professor, medicine, University of Florida, Gainesville; November 2007 Journal of the American College of Cardiology

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. New insights into inflammation in osteoarthritis
3. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
4. Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
5. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
6. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
7. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
8. Elliott Extremely Dissatisfied With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company
9. Study shows adverse drug events reported to the FDA have significantly increased
10. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
11. Ericom Provides Significant Cost-Savings for Major New York City Healthcare Organization
Post Your Comments:
Related Image:
Inflammation Can't Explain Depression's Link to Heart Disease
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... HMP , ... recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ ... on October 11, 2017. , The annual award competition recognizes editorial and design excellence ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  According to the Centers for Disease Control and ... October . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the ... certain health insurance regulations. ... time to get a flu shot is by the end of October, ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
Breaking Medicine Technology: