Navigation Links
Inflammation, depression and antidepressant response: Common mechanisms
Date:5/29/2008

Major depressive disorder is a common and complex condition that impacts about 15% of the population of the United States, yet very little is known about the mechanisms behind the psychiatric disorder. What is known is that there are clinical parallels between depressive symptoms and the symptoms of certain inflammatory disorders.

In findings published electronically in Molecular Psychiatry, researchers from University of Miami found polymorphisms in inflammation-related genes that are associated with susceptibility to major depression and antidepressant response. Two genes critical for T-cell function in the immune system have been associated with susceptibility for major depressive disorder and antidepressant treatment response: PSMB4 (proteasome beta 4 subunit) and TBX21 (T-bet).

The study population was made up of 284 depressed Mexican-Americans from Los Angeles who were already enrolled in a pharmacogenetic study of antidepressant treatment response. The control group was made up of 331 individuals from the same community.

Our findings suggest that a simple blood test to look for these genes could help us identify people who are at risk for depression, said Ma-Li Wong, M.D., professor and vice chair for translational research in the Department of Psychiatry and Behavioral Sciences at the Miller School of Medicine and lead author of the study. We would know to watch these people in stressful situations, such as a soldier in combat, and intervene earlier to get them the help they need.

Interestingly, genetic variations in PSMB4 and TBX21 may also be relevant to two immune disorders, psoriasis and asthma. Both of these disorders are known to be co-morbid withmajor depressive disorder and are related to psychosocial stressors.


'/>"/>

Contact: Ma-Li Wong
mali@miami.edu
305-323-6808
Molecular Psychiatry
Source:Eurekalert

Page: 1

Related medicine news :

1. Mergent, Inc. Announces Changes to the HealthShares(TM) Composite, Enabling Technologies, Autoimmune-Inflammation, Cancer, Cardiology and Neuroscience Indexes
2. Pathway links inflammation, angiogenesis and breast cancer
3. Buyers Health Care Action Group Pilots New Bridges to Excellence Program for Depression
4. Antidepressants May Prevent Depression After Stroke
5. Anthem Blue Cross Foundation Supports National Campaign Focused on Depression Among Men
6. Medication may prevent depression in patients with head and neck cancer
7. JAMA publication features study on depression and head and neck cancer
8. Depression, PTSD Common Among Lung Transplant Patient Caregivers
9. Depression and PTSD symptoms in caregivers of lung transplant patients
10. Low Vitamin D Tied to Depression in Older Adults
11. Depression and anger can plague recent university graduates: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 01, 2014 Marriagelifeinsurance.com has released ... insurance for retired couples. , Senior citizens can ... security for their loved ones. A joint policy is ... persons pass away. , Life insurance can be ... insurance can even be purchased online, as the application ...
(Date:10/1/2014)... October 01, 2014 Bedros Keuilian is ... Boot Camp fitness boot camps, he’s also considered the ... , with sold out business summits, a line of ... consultant to a recent Spike TV reality show to ... now is the time for personal trainers and fitness ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 First Warning ... abnormal circadian cellular changes throughout the body, announced the ... to better address the company’s breadth of upcoming product ... breast cancer screening technology. , “Our initial focus will ... system which detects abnormal circadian cellular changes over time,” ...
(Date:10/1/2014)... October 01, 2014 T.E.N., ... and relationship-marketing firm, announced today the nominees ... and Project of the Year Awards for ... representing organizations in financial services, commercial, health ... technology endeavors that address key issues in ...
(Date:10/1/2014)... MO (PRWEB) October 01, 2014 Join the ... Castlewood Eating Disorder Treatment Center’s first ever charity golf tournament ... for people with eating disorders who cannot afford treatment. The ... Golf Club in Eureka, Mo. , The day-long event ... noon. A reception and award dinner will begin at 5 ...
Breaking Medicine News(10 mins):Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3
... Cancer,Center announced that Judy and Larry Freeman have ... Comprehensive Cancer Center, Keck School of,Medicine of USC. ... Freeman Cancer,Day Hospital, an outpatient facility currently located ... Larry Freeman is the founder of Freeman,Cosmetics Corporation, ...
... contains minerals that provide safe, effective prevention,and relief from ... 23 Dr. Howard Peiper, a Pulitzer prize,nominated author, ... 12 best sellers. Dr. Peiper is recommending a brand ... Zeolite-AV,and is the first all natural product ever created ...
... do not routinely remove cancer from the lungs may be ... conducted by researchers at Duke University Medical Center. , "Our ... types of surgeries have correspondingly lower mortality rates than those ... an anesthesiologist at Duke and lead investigator on the study. ...
... to end the symptoms of her diabetes. Jeannie Baellow, 54, was chosen ... the Lifestyle Center of America (LCA). , ... New York, NY (PRWEB) ... fight to end the symptoms of her diabetes. Jeannie Baellow, 54, was ...
... Oct. 22 Every year in Jacksonville,nearly 600 ... until now,their long road to recovery lacked long-term ... Clubhouse, the only program,in Florida created to help ... to community reintegration., The Brain Injury Association ...
... to Steal, SAN FRANCISCO, Oct. 22 ... identity theft, and in a lawsuit filed against ... claims that the,credit industry is facilitating the crimes. ... identity verification systems, credit,card companies such as Bank ...
Cached Medicine News:Health News:USC Cancer Center Announces Contribution By Larry and Judy Freeman 2Health News:Doctor Recommends New Powerful Natural Antiviral Against the Flu 2Health News:Doctor Recommends New Powerful Natural Antiviral Against the Flu 3Health News:Study finds that practice makes perfect in lung cancer surgery 2Health News:Video Blog Chronicles One Woman's Fight Against Her Diabetes 2Health News:Brooks Rehabilitation Opens First Work-Based Brain Injury Rehab Program in Florida 2Health News:Credit Card Companies Accomplices in Millions of Identity Theft Cases Alleges Eric Drew 2
(Date:10/1/2014)... Calif. , Oct. 1, 2014  Varian Medical ... it will report results for the fourth quarter of ... on Wednesday, October 22, 2014.  The news release will ... parties at 2:00 p.m. PT.  The news release and ... available on the company website at: www.varian.com/investor .  ...
(Date:10/1/2014)... , Oct. 1, 2014 Quantum ... scaling volume production of photoactive quantum dots for ... . While offering numerous advantages for solar power ... large quantities of quantum dots with which to ... kept them from commercial utilization and acceptance. The ...
(Date:10/1/2014)... FREMONT, Calif. , Oct. 1, 2014 ... ARDX ), a clinical-stage biopharmaceutical company focused ... announced positive results from its 371 patient ... patients with constipation-predominant irritable bowel syndrome (IBS-C).  ... and clinically meaningful improvement in IBS-C symptoms ...
Breaking Medicine Technology:Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 2Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 4Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 5Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 6
... Normal and Abnormal Control ... of vWF, D-dimer and ... STA© Analyzers. For use ... (#0518),STA© LIATEST© D-DI (#0515) ...
CRP Full Range (0.1-160mg/l)...
Inquire...
Sera available in three levels for the control of accuracy and precision for up to 31 analytes...
Medicine Products: