Study found infertile men were 2.6 times more likely to get more dangerous disease
MONDAY, March 22 (HealthDay News) -- Infertility increases the risk that a man will develop the aggressive, potentially fatal form of prostate cancer, a new study suggests.
"To my knowledge, this is the first study to identify a link between male factor infertility and prostate cancer," said Dr. Thomas J. Walsh, an assistant professor of urology at the University of Washington, and lead author of a report published online March 22 in the journal Cancer.
There have been hints in previous studies of such a link, Walsh said, but those studies had a built-in bias, since they looked specifically at men who were screened by urologists because they were identified as being infertile, rather than comparing their risk of prostate cancer with that of all other men.
The new study avoided that bias by using a statewide database of prostate cancer cases maintained in California. The incidence of prostate cancer in that general population was compared with the incidence of prostate cancer in 22,562 men evaluated for infertility at 15 California centers between 1967 and 1998.
The overall incidence of prostate cancer in the two groups was about the same, the study found. But a difference emerged when the aggressiveness of the tumors was measured by the Gleason score, which looks for degree of abnormal organization of a prostate tumor. A higher Gleason score is an indicator of aggressive growth, and the incidence of cancers with high Gleason scores was 2.6 times higher in the infertile men.
There are several possible explanations for the relationship, none of them as yet proven, Walsh said. "There could be underlying genetic abnormalities on the male chromosome," he said. "Also, these men may have a deficit in their ability to repair DNA; there is some evidence that this may be the underlying cause."
But there are
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