Navigation Links
Infertility Raises Risk of More Aggressive Prostate Cancer
Date:3/22/2010

Study found infertile men were 2.6 times more likely to get more dangerous disease

MONDAY, March 22 (HealthDay News) -- Infertility increases the risk that a man will develop the aggressive, potentially fatal form of prostate cancer, a new study suggests.

"To my knowledge, this is the first study to identify a link between male factor infertility and prostate cancer," said Dr. Thomas J. Walsh, an assistant professor of urology at the University of Washington, and lead author of a report published online March 22 in the journal Cancer.

There have been hints in previous studies of such a link, Walsh said, but those studies had a built-in bias, since they looked specifically at men who were screened by urologists because they were identified as being infertile, rather than comparing their risk of prostate cancer with that of all other men.

The new study avoided that bias by using a statewide database of prostate cancer cases maintained in California. The incidence of prostate cancer in that general population was compared with the incidence of prostate cancer in 22,562 men evaluated for infertility at 15 California centers between 1967 and 1998.

The overall incidence of prostate cancer in the two groups was about the same, the study found. But a difference emerged when the aggressiveness of the tumors was measured by the Gleason score, which looks for degree of abnormal organization of a prostate tumor. A higher Gleason score is an indicator of aggressive growth, and the incidence of cancers with high Gleason scores was 2.6 times higher in the infertile men.

There are several possible explanations for the relationship, none of them as yet proven, Walsh said. "There could be underlying genetic abnormalities on the male chromosome," he said. "Also, these men may have a deficit in their ability to repair DNA; there is some evidence that this may be the underlying cause."

But there are indications that the increased risk may be related in some way to male hormones, Walsh said. Studies have found a lower risk of prostate cancer in men who grow bald earlier in life, he said, and baldness is often caused by androgen activity.

The apparent link between infertility and increased prostate cancer risk can be put to medical use, Walsh said. When inability to father children is suspected, "we may want to screen these men more aggressively for prostate cancer," he said.

The finding "may provide clues as to how we can identify the underlying reasons why some prostate cancers are aggressive and most aren't," said Robert A. Smith, director of cancer screening for the American Cancer Society.

It may also add a factor to be considered when the issue of screening comes up, Smith said. The society does not recommend routine screening with a test for prostate-specific antigen, he noted, but says the issue should be made on the basis of individual factors, such as family history. Infertility may become such a factor, Smith said.

But since this is a first study, "it needs to be confirmed in other populations of men," Walsh said. "It is up to scientists to confirm the findings and do basic research to enable us to understand the link."

And men who might have fertility problems need not panic about cancer, he said. "The absolute risk of cancer is still very low," Walsh said. "No man need be alarmed unduly."

More information

Learn about prostate cancer and its treatment from the U.S. National Cancer Institute.



SOURCES: Thomas J. Walsh, M.D., assistant professor, urology, University of Washington, Seattle; Robert A. Smith, Ph.D., director, cancer screening, American Cancer Society, Atlanta; March 22, 2010, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Infertility increases a mans risk of prostate cancer
2. Leading U.S. Infertility Practice Opens Boston IVF The Maine Center in Portland, Helping Build Families in Maine
3. Doctors miss major cause of infertility and obesity
4. New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem
5. Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
6. Women Arent Waiting to Seek Infertility Help
7. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
8. DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform
9. Erectile Dysfunction Plus Heart Disease Raises Death Risk
10. AdMeTech Praises Rep. Cummings for Introducing $650 Million Prostate Research Bill
11. Genetic Variant Raises Lung Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... ... Southland Log Homes , designer and manufacturer of America’s Favorite Log ... be found on its website at SouthlandLogHomes.com. , The designs of the wood ... craftsmanship of timber post and beam construction. The result is a barn that ...
(Date:5/27/2016)... , ... May 27, 2016 , ... W.S. Badger ... announced today that it has been recognized as one of the best small businesses ... was named as one of nine small businesses providing progressive benefits to new parents ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... With over ... to walk, the demand for a sustainable product to aid in the rehabilitation process ... aid in the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, ... ... caregivers to casual readers, this installment is bolstered by inspiring human-interest stories, courtesy ... trends and tech within the industry, from leading advocates, associations and industry leaders ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active ... time that Coolsculpting is being used for for more than just cosmetic purposes. ... the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... May 27, 2016 Hutchison ... company focused on the highly lucrative global oncology ... pipeline of potential first-in-class or best-in-class tyrosine kinase ... development with strategic partners. HCM,s profitable Chinese healthcare ... market. We expect progress of the mid-to-late-stage pipeline ...
(Date:5/27/2016)... 27, 2016 Amarantus BioScience Holdings, Inc. ... products for Regenerative Medicine, Neurology and Orphan Diseases, today announced that ... at two upcoming investor conferences: SeeThru Equity MicroCap ... New York City , NY When: ... Marcum MicroCap Conference   Where: Grand Hyatt Hotel, 109 ...
(Date:5/26/2016)... , May 26, 2016 According to ... Waste Management Market - U.S. Industry Analysis, Size, Share, Growth, ... market in the U.S. was valued at US$ 5.89 Bn ... of 3.4% from 2015 to 2023 to reach US$ 7.99 ... of current and emerging needle free drug delivery devices and ...
Breaking Medicine Technology: