Navigation Links
Infertility Raises Risk of More Aggressive Prostate Cancer
Date:3/22/2010

Study found infertile men were 2.6 times more likely to get more dangerous disease

MONDAY, March 22 (HealthDay News) -- Infertility increases the risk that a man will develop the aggressive, potentially fatal form of prostate cancer, a new study suggests.

"To my knowledge, this is the first study to identify a link between male factor infertility and prostate cancer," said Dr. Thomas J. Walsh, an assistant professor of urology at the University of Washington, and lead author of a report published online March 22 in the journal Cancer.

There have been hints in previous studies of such a link, Walsh said, but those studies had a built-in bias, since they looked specifically at men who were screened by urologists because they were identified as being infertile, rather than comparing their risk of prostate cancer with that of all other men.

The new study avoided that bias by using a statewide database of prostate cancer cases maintained in California. The incidence of prostate cancer in that general population was compared with the incidence of prostate cancer in 22,562 men evaluated for infertility at 15 California centers between 1967 and 1998.

The overall incidence of prostate cancer in the two groups was about the same, the study found. But a difference emerged when the aggressiveness of the tumors was measured by the Gleason score, which looks for degree of abnormal organization of a prostate tumor. A higher Gleason score is an indicator of aggressive growth, and the incidence of cancers with high Gleason scores was 2.6 times higher in the infertile men.

There are several possible explanations for the relationship, none of them as yet proven, Walsh said. "There could be underlying genetic abnormalities on the male chromosome," he said. "Also, these men may have a deficit in their ability to repair DNA; there is some evidence that this may be the underlying cause."

But there are indications that the increased risk may be related in some way to male hormones, Walsh said. Studies have found a lower risk of prostate cancer in men who grow bald earlier in life, he said, and baldness is often caused by androgen activity.

The apparent link between infertility and increased prostate cancer risk can be put to medical use, Walsh said. When inability to father children is suspected, "we may want to screen these men more aggressively for prostate cancer," he said.

The finding "may provide clues as to how we can identify the underlying reasons why some prostate cancers are aggressive and most aren't," said Robert A. Smith, director of cancer screening for the American Cancer Society.

It may also add a factor to be considered when the issue of screening comes up, Smith said. The society does not recommend routine screening with a test for prostate-specific antigen, he noted, but says the issue should be made on the basis of individual factors, such as family history. Infertility may become such a factor, Smith said.

But since this is a first study, "it needs to be confirmed in other populations of men," Walsh said. "It is up to scientists to confirm the findings and do basic research to enable us to understand the link."

And men who might have fertility problems need not panic about cancer, he said. "The absolute risk of cancer is still very low," Walsh said. "No man need be alarmed unduly."

More information

Learn about prostate cancer and its treatment from the U.S. National Cancer Institute.



SOURCES: Thomas J. Walsh, M.D., assistant professor, urology, University of Washington, Seattle; Robert A. Smith, Ph.D., director, cancer screening, American Cancer Society, Atlanta; March 22, 2010, Cancer, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Infertility increases a mans risk of prostate cancer
2. Leading U.S. Infertility Practice Opens Boston IVF The Maine Center in Portland, Helping Build Families in Maine
3. Doctors miss major cause of infertility and obesity
4. New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem
5. Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
6. Women Arent Waiting to Seek Infertility Help
7. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
8. DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform
9. Erectile Dysfunction Plus Heart Disease Raises Death Risk
10. AdMeTech Praises Rep. Cummings for Introducing $650 Million Prostate Research Bill
11. Genetic Variant Raises Lung Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... 2017 , ... MarkeTouch Media has partnered with fred’s Pharmacy ... modern design with a more streamlined user experience and is designed to improve ... includes hundreds of digital coupons that can be clipped to a customer’s account ...
(Date:9/19/2017)... ... 2017 , ... With Netmail Hadron, construction companies ... States, can easily manage all of their data, apply policies on that data, ... “As a construction company,” says Ryan Sinnwell, the Infrastructure Manager at The Weitz ...
(Date:9/18/2017)... ... September 19, 2017 , ... Sarantos For The ... This December , Sarantos is proud to be the 1st (and continues to be ... song release. A new song, music video, book chapter and behind the scenes video ...
(Date:9/18/2017)... ... September 18, 2017 , ... A September 7 article ... that aspirin, one of the world’s most common and least expensive medications, may be ... dentist Dr. Farzad Feiz of California Dental Group and Calabasas Dental Care says that, ...
(Date:9/18/2017)... ... September 18, 2017 , ... Altec Products, Inc., ... DocLink Advanced Admin Training in Irvine, CA. The four-day training session, which ... that will allow them to manage DocLink more efficiently and effectively. , Covering ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
(Date:9/9/2017)... Lilly and Company (NYSE: LLY ) will ... an investigational, oral, first-in-class molecule for the acute treatment ... placebo in the Phase 3 SPARTAN study. Detailed results ... the International Headache Society (IHC) in Vancouver ... lasmiditan,s potential to reduce pain and provide freedom from ...
(Date:9/7/2017)... Sept. 7, 2017 Caris Life Sciences, ... fulfilling the promise of precision medicine, today announced ... benefits of its molecular profiling approach in guiding ... genomic profiling plus (CGP+) with Caris Molecular Intelligence ... on a molecular level, leading to more therapeutic ...
Breaking Medicine Technology: