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Infectious Disease Research Institute Receives Grant from the Bill & Melinda Gates Foundation for Adjuvant Access and Development
Date:12/3/2007

SEATTLE, Dec. 4 /PRNewswire/ -- The Infectious Disease Research Institute (IDRI), a Seattle-based non-profit scientific research institute, announced today that it has received a $29,947,850 five year grant from the Bill & Melinda Gates Foundation. The grant will be used to provide adjuvants (essential components for many vaccines) for priority malaria vaccine candidates. Advances arising from this project are likely also to facilitate development of vaccines against other neglected diseases.

Adjuvants are vaccine components that, when appropriately formulated and combined with an antigen, direct the immune system to give an effective response while boosting the potency and longevity of the specific immune responses. Most adjuvants are owned by large pharmaceutical companies and not easily accessible to researchers developing vaccines for neglected diseases. IDRI seeks to provide the public sector with safe, effective, low-cost adjuvants through component testing and licensing, product improvement, development of adjuvant-antigen formulations, and the creation of an adjuvant library.

With this grant, IDRI will focus on adjuvants for malaria vaccines. Because malaria parasites have a complex life cycle, creating an effective vaccine is a major scientific challenge. Worldwide, every year between 350 million and 500 million people are infected with malaria and more than 1 million die from this preventable disease. To accelerate the fight against malaria, IDRI will obtain access to adjuvants with proven clinical potential in malaria vaccines and will develop next-generation adjuvant formulations for malaria vaccine candidates.

"This grant enables IDRI to help advance the development of malaria vaccines," said Dr. Steven Reed, Founder and Head of IDRI's Research and Development Program. "We are honored that the Gates Foundation has provided this opportunity and look forward to working with researchers in the field of malaria."

IDRI, in partnership with the World Health Organization in Geneva, will work closely with the PATH Malaria Vaccine Initiative and other agencies and investigators to select priority malaria antigens for preliminary development and testing of these adjuvant formulations.

About IDRI

IDRI is a non-profit organization committed to developing technologies to treat "neglected" diseases that place a significant burden on those living in the developing world. IDRI achieves its mission by working closely with industry, universities, and hospitals in developed and developing countries, government and private funding agencies, and the World Health Organization. For more information, go to http://www.idri.org.


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SOURCE The Infectious Disease Research Institute
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