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Infections cause lower proportion of lead extractions than expected
Date:9/3/2013

Amsterdam, The Netherlands Tuesday 3 September 2013: Infections cause a lower proportion of lead extractions than expected, according to preliminary results from the ELECTRa Registry presented at ESC Congress 2013 today by Dr Maria Grazia Bongiorni from Italy.

The European Lead Extraction ConTRolled (ELECTRa) Registry is the first large prospective, multicentre, European controlled registry of consecutive patients undergoing transvenous lead extraction (TLE) procedures in European real world practice. It is carried out by the European Heart Rhythm Association (EHRA) and managed by the ESC's EORP programme.1

Dr Bongiorni said: "The implantation rate of cardiovascular implantable electronic devices (CIEDs) continues to rise in most countries in Europe and in the US.2-6 The number of leads per patient is increasing due to a higher proportion of dual versus single chamber devices and an increase in implantations."

She added: "Despite developments in technology and improvements in reliability, leads remain the weak point of CIED systems and in some cases may fail and require extraction. Extractions are also needed due to infections. In recent years, an increasing number of European centres have started performing TLE procedures7 and data is needed on appropriate indications, techniques, success rates, safety and follow-up."

The primary aims of the ELECTRa Registry are to evaluate the acute and long-term safety of TLE and quantify major procedure related complications (including death) in acute and long-term follow-up. It is anticipated that over 100 centres from 25 countries will join the programme. Each centre will enroll consecutive patients undergoing TLE from November 2012 to January 2014 and follow them for 1 year. The target for statistical analysis is at least 3,500 patients. At the end of July 1,200 patients were enrolled.

Preliminary results show that infections were the indication for lead extraction in 52% of cases. Dr Bongiorni said: "Infections are the first reason for lead extractions but they were expected to be responsible for a higher proportion.3,8 This result might be related to the fact that lead malfunctions have increased in recent years and therefore the proportion of non-infectious indications have increased as well."

More than 60% of patients had diabetes or hypertension (see figure 1). Dr Bongiorni said: "A high proportion of patients requiring lead extraction had these risk factors for cardiovascular disease. They are both typical cardiovascular risk factors and prominent comorbidities of patients with CIEDs. Diabetes is also a risk factor for infections and therefore it could be related to the extractions for infectious cause."

CIED systems with more than a single lead were the most represented in the registry (dual chamber pacemaker, CRT-Defibrillator, dual chamber defibrillator, CRT-Pacemaker) (see figure 2). Dr Bongiorni said: "These findings are in line with the worldwide trend where more complex devices are correlated with more complications, hence the requirement for more lead extractions."

She concluded: "This important study will provide more accurate knowledge of outcomes in real world clinical practice. The data will be used to improve the quality of lead extraction, set standards for these procedures, and improve patient results."


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Contact: Jacqueline Partarrieu
press@escardio.org
44-754-070-4494
European Society of Cardiology
Source:Eurekalert

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