Navigation Links
Infection With 2 HIV Strains Slows Disease Progression
Date:7/19/2012

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, July 18 (HealthDay News) -- While many people don't know it, there's more than one kind of AIDS virus. Besides the HIV-1 strain that's common throughout the world, a type known as HIV-2 is found in some parts of Africa. Now, a new study finds that people infected with HIV-2 and later with HIV-1 appear to be better equipped to fight off the virus.

Double-infected people can still go on to develop AIDS, and there's no indication that anyone infected with HIV-1 should go out in search of HIV-2.

However, "this study should prompt researchers to take a fresh look at HIV-2 infection" and why it seems weaker, and the potential implications for a vaccine, said Sarah Rowland-Jones, an AIDS specialist and professor of immunology at John Radcliffe Hospital in Oxford, England.

The big questions, she said, are these: Is there something about the HIV-2 virus that makes it less dangerous to the human body's immune system defenses? Or is it perhaps the other way around, and the body's defenses are the key?

"If we understood this, it would have a lot of relevance for HIV vaccine design," said Rowland-Jones, who's familiar with the new study's findings.

The HIV-2 strain is largely found in West Africa and hasn't spread much beyond there, although there have been cases reported in Europe, India, Japan and the United States, Rowland-Jones said. Many people who are infected with the HIV-2 virus develop AIDS and die, but some live normal lives, she said.

The new study looked at West Africans in the country of Guinea-Bissau and focused on 223 people who first became infected with HIV-2 and then with HIV-1 or those who only got the HIV-1 strain.

The researchers tracked the patients for about 20 years. They found that it took an average of 104 months (nine years) for those with dual infections to develop AIDS, but just 68 months (nearly six years) for those infected solely with the HIV-1 virus.

"Those infected with HIV-2 first seem to be better prepared to handle the more aggressive HIV-1 infection and thereby have a longer progression time to AIDS," said study lead author Joakim Esbjörnsson, a postdoctoral researcher at Lund University, in Sweden.

"It is clear that the effect is huge," Esbjörnsson said, and it probably affects death rates, too.

Esbjörnsson emphasized that the research only looked at people who became infected with HIV-2 first: "People already single-infected with HIV-1 should under no circumstances try to get infected with HIV-2," he said.

Phyllis Kanki, an AIDS specialist and professor of immunology and infectious diseases at the Harvard School of Public Health, suggested that people who get infected with HIV-2, which affects the body more slowly, may develop better defenses against the virus. That, in turn, could help them more effectively fight the HIV-1 strain, she said.

The study appears in the July 19 issue of The New England Journal of Medicine.

More information

To learn more about HIV, visit the U.S. National Library of Medicine.

SOURCES: Sarah Rowland-Jones, AIDS specialist and professor of immunology, John Radcliffe Hospital, Oxford, England; Joakim Esbjörnsson, Ph.D., Department of Experimental Medical Science, Lund University, Lund, Sweden; Phyllis Kanki, DVM, AIDS specialist and professor of immunology and infectious diseases, Harvard School of Public Health, Boston; July 19, 2012, New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Lungs respond to hospital ventilator as if it were an infection
2. Reporting of hospital infection rates and burden of C. difficile
3. FDA Approves 1st Pill to Help Prevent HIV Infection
4. Helper T cells, not killer T cells, might be responsible for clearing hepatitis A infection
5. UW scientists discover why human body cannot fight HIV infection
6. More Proof Cranberry Juice Thwarts Infection
7. Einstein receives nearly $5 million to study how Ebola causes infection
8. UCLA study to determine if copper surfaces can reduce hospital-acquired infections
9. Uncircumcised Boys at Higher Risk for Infection: Study
10. HPV Vaccine Reducing Infections, Even Among Unvaccinated: Study
11. HPV vaccine reduces infection, even in unvaccinated
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Infection With 2 HIV Strains Slows Disease Progression
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
Breaking Medicine Technology: