Navigation Links
Infected Tasmanian devils reveal how cancer cells evolve in response to humans
Date:2/18/2014

Tasmanian Devil Facial Tumour Disease (DFTD) has ravaged the world's largest carnivorous marsupial since it emerged in 1996, resulting in a population decline of over 90%. Conservation work to defeat the disease has including removing infected individuals from the population and new research in Evolutionary Applications explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells.

DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33% of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

However, this parasitical disease has been able survive and counteract the effect of deleterious mutation, genomic instability as well as being able to infect more than 100,000 devils.

"In this study, we focus on the evolutionary response of DFTD to a disease suppression trial," said Beata Ujvari, from the, The University of Sydney. "Tumours collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumours from other populations where no increase of tetraploid tumours were observed."

The disease eradication trial provides a unique opportunity to discover the long-term effects of human selection on DFTD evolution and to explore this, the team collected tumour tissue samples between 2006 and 2011 at 11 sites within the DFTD affected areas of Tasmania.

"Our study clearly demonstrates that DFTD tumours are able to rapidly respond to increased selection and adapt to a selective regime," said Ujvari. "The results suggest that ploidization may offer yet another pathway to which DFTD is able to adapt to the ever-changing evolutionary landscape sculptured by the devils' immune system. Our study is the first to show that anthropogenic selection may enhance cancer evolution in the wild, and it therefore cautions about what measures we employ to try to halt the spread of this devastating disease."


'/>"/>
Contact: Ben Norman
Sciencenewsroom@wiley.com
44-012-437-70375
Wiley
Source:Eurekalert  

Related medicine news :

1. NIH-created toxin can kill HIV-infected cells that persist despite treatment
2. The Best Christmas Wish of STD Infected People Is to Find a Match According to The Survey on Members of PositiveSingles.com
3. 61 Percent Herpes Infected People On PositiveSingles.com Said Condoms Make Things Safer
4. The Inspirational Stories on PositiveSingles Proved to Be Very Helpful for STD Infected People
5. U of M researchers find HIV protein may impact neurocognitive impairment in infected patients
6. HIV antibody infusions show promise for treating SHIV-infected monkeys
7. PositiveSingles.Com Will Cancel the Accounts of Members Not Infected with an STD
8. Fear of Rejection- The Main Reason That STD Infected People Intentionally Spread Sexually Transmitted Diseases to Others
9. Tufts researchers identify how Yersinia spreads within infected organs
10. UC Davis Children's Hospital Saves the Life of 14-year-old Bishop, Calif. Teen Infected with Hantavirus
11. JPIDS explores trends in perinatally infected HIV patients now approaching adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Infected Tasmanian devils reveal how cancer cells evolve in response to humans
(Date:6/28/2017)... ... June 28, 2017 , ... ... financial consultations to communities in northern Virginia and DC, is announcing a cooperative ... for patients with Alzheimer’s and other disorders that lead to memory impairment. , ...
(Date:6/27/2017)... ... June 27, 2017 , ... Nearly 70 percent of ... released today by the American Society for Dermatologic Surgery (ASDS). , ... of consumers considering a cosmetic medical procedure has doubled since 2013. , “Cosmetic ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... for many of the health care industry’s hospitals and provider groups, has announced ... portal for select customers. Parasail Health is a San Francisco health-finance startup that ...
(Date:6/27/2017)... ... ... From June 20-22, EarQ and Widex held an exclusive training event ... is headquartered. , Together, the organizations educate hearing care professionals on how to ... latest in hearing technology. At the event, EarQ members got an in-depth look ...
(Date:6/27/2017)... ... June 27, 2017 , ... The Kelahan Agency, ... services to residents of southern New Hampshire, is teaming up with the New ... hunger and homelessness in the region. , New Horizons for New Hampshire provides ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... June 19, 2017  Researchers from DRUGSCAN ® ... will host a live, complimentary webinar titled, "Untangling methods ... to the real world" on Wednesday June 28, 2017 ... This webinar will feature interviews with recreational and ... the manipulation techniques abusers use to prepare opioid tablets ...
(Date:6/14/2017)... -- In 2016, Embodied Labs took top prize ... came away with $25,000 in seed-fund investment. Embodied Labs ... "entering the life of another" and by the Journal ... medical professionals in an entirely new dimension." Building upon ... for the Department of Education,s EdSimChallenge, where they received ...
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. ... focused on the design, manufacture, sale and distribution of ... on the progress of its commercial roll-out in ... available in more than one hundred (100) medical institutions ... AeroForm offers a needle-free alternative for women who ...
Breaking Medicine Technology: