Navigation Links
Infant immune systems learn fast, but have short memories
Date:6/11/2014

ITHACA, N.Y. Forgetful immune systems leave infants particularly prone to infections, according to a new Cornell University study. Upending the common theory that weak immune cells are to blame, the study has found that infants' immune systems actually respond to infection with more speed and strength than adults, but the immunities they create fail to last.

Published in the Journal of Immunology, the discovery reveals a new angle immunizations could take in protecting infants and children from infectious diseases.

"The perfect vaccine would be a single dose given at birth that generates long-lasting immunity," said immunologist Brian Rudd at Cornell's College of Veterinary Medicine, the study's lead author. "No such vaccine exists because we haven't understood why infants rapidly lose immunities. Our finding could change the way we immunize infants and ultimately lead to more effective ways of enhancing immunity in early life."

Immunity against most microbes depends on forming "memory T cells" that remember specific pathogens and can rapidly respond to future infections. Adults almost always generate large numbers of effective memory T cells during infection, around 10 percent of which stay in a long-lived memory pool to rapidly respond next time.

Rudd found that newborn T cells generated in response to infection met dramatically different fates. When faced with the same pathogen, newborn immune systems made T cells that responded more rapidly to infection than adult cells, but quickly became terminally differentiated, never making it into the memory pool.

"So the immune system is forced to start the learning process over again when infected by the same pathogen later in life." Rudd said.

"We hope to find a way to make neonatal cells behave more like adult cells in how they learn from vaccines and respond to infection. Knowledge gained from these studies could be used to design more effective therapeutic interventions and vaccines that can be safely administered in early life."


'/>"/>

Contact: Melissa Osgood
mmo59@cornell.edu
607-255-2059
Cornell University
Source:Eurekalert

Related medicine news :

1. MRI shows brain abnormalities in late preterm infants
2. Despite economic blows, infant health has improved among US poor
3. UT Dallas study sheds light on how infants understand speech
4. Medication does not lower risk of fungal infection, death among ELBW infants
5. Outcomes of steroid therapy following surgery for infants with bile duct disorder
6. Steroids after surgery do not help infants with rare liver disease
7. Despite recommendations for safer sleeping, infant deaths persist
8. Many parents dont follow safe infant sleep practices
9. Many infants still not placed on their backs to sleep
10. New study says probiotic use for infant colic is not effective in reducing symptoms
11. Scientists describe gut bacteria that cause sepsis in preterm infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... , ... December 06, 2016 , ... ... organization, is proud to announce it has added CXC Solutions (CXC) as a ... solutions. These solutions are tailored to help benefits advisors reduce operating costs ...
(Date:12/6/2016)... , ... December 06, 2016 , ... ... one-stop portal for all the knowledge resources, including white papers, guides, handbooks, case ... more. , To access more than 9,000 documents, webinars and videos available ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana ... a powerful woman's story of sacrifice and enlightenment. , “Tatiana Sibirskaya: ... Carolyn Fryer. Always looking for creative outlets, Carolyn gravitated toward writing through the ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates ... Top 125 for their industry leading training methods that engage their associates and ... among the global elite in employer-sponsored training and development programs. , “The 2017 ...
(Date:12/5/2016)... (PRWEB) , ... December 06, 2016 , ... For many ... Lithuanian poetry , both thick and thin. The beauty of the Lithuanian language ... Trafford Publishing). , In this poetry book, Zubinas lyrically explores all aspects of a ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... Dec. 6, 2016 /PRNewswire/ - InMed Pharmaceuticals, Inc. ... on its R&D program in the use of ... disease (COPD). In June, 2015 InMed initiated its ... identify the targets and potential active compounds that ... Subsequently, with in vitro assays using human lung ...
(Date:12/5/2016)... -- Balloon catheter is an innovative medical device that comprises ... artery in the leg or sometimes into the radial ... These products are generally used to prevent blood vessel ... substances in the blood vessel. In terms of revenue, ... at a CAGR of 3.8% during the forecast period ...
(Date:12/5/2016)... 5, 2016 Spain Glaucoma Surgery Devices Market ... "Spain Glaucoma Surgery Devices Market Outlook to 2022", provides ... market. The report provides value, in millions of US ... market segements - Canaloplasty Micro Catheters and Glaucoma Drainage ... distribution shares data for each of these market segements, ...
Breaking Medicine Technology: