Navigation Links
Inexpensive Compound Could Treat Severe Diarrhea
Date:6/17/2008

Finding may be 'magic bullet' to help miilions of children in developing world, study says

TUESDAY, June 17 (HealthDay News) -- A new compound that may lead to an inexpensive, easy-to-take treatment for diarrhea has been discovered by researchers at the University of Texas Health Science Center at Houston.

This finding may prove especially important for developing countries, where diarrhea is a major cause of child deaths. Diarrhea kills an estimated 1.6 million to 2.5 million children a year, according to information published by the World Health Organization.

The new compound -- a pyridopyrimidine derivative -- targets E. coli and other enterotoxigenic strains of bacteria that cause acute secretory diarrhea. These bacteria produce toxins that stimulate the linings of the intestines, causing them to secrete excessive fluid, resulting in diarrhea.

In preclinical tests on animals infected with diarrhea-causing bacteria, the new compound was associated with a significant reduction in intestinal fluid secretion. The compound also reduced fluid build-up in laboratory tests on human cells. There was no indication of toxicity caused by the compound.

The research was published in the June 16 online edition of the journal Proceedings of the National Academy of Sciences.

"While this research looks extremely promising as a preventive or therapeutic intervention in Third World diarrheal disease and traveler's diarrhea, much work remains to be done to move into clinical trials and eventual therapeutic approval," study senior author Dr. Ferid Murad cautioned in a prepared statement.

A drug based on this compound may also prove effective in treating inflammatory bowel disease and some endocrine disorders, Murad said.

The discovery of this compound is "a promising lead," said Dr. Stanley G. Schultz, a cellular signaling expert at the University of Texas Medical School at Houston who was not involved in the study.

"An inexpensive drug that could block the intestinal secretory pathway, with minimal side effects, would be a 'magic bullet' that would not only save millions of lives in many parts of the developing world, but would also save the billions of dollars that are lost annually because of diarrhea throughout the world. It would truly be a treatment of diarrhea rather than a treatment of the consequences of diarrhea," Schultz said in a prepared statement.

Currently, there is no effective way to directly treat secretory diarrhea. Treatment is aimed at minimizing fluid loss through intravenous or oral rehydration.

More information

The American College of Gastroenterology has more about diarrheal diseases.



-- Robert Preidt



SOURCE: University of Texas Health Science Center at Houston, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel
2. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
3. Inexpensive Online Pain Education Program for Physicians as Effective as Live Presentations by National Experts
4. UCR chemists use green chemistry to produce amines, chemical compounds used widely in industry
5. Telik Announces Patents on Compounds Related to TELINTRA
6. New PA Economic Study: Bush Medicare Cuts Compound State Medicaid Crisis
7. Red Wine Compound Helps Heart, May Slow Aging
8. New Compound Slows HIV Replication
9. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
10. Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol
11. Grapefruit Compound Inhibits Hepatitis C Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: