Navigation Links
Inexpensive Compound Could Treat Severe Diarrhea
Date:6/17/2008

Finding may be 'magic bullet' to help miilions of children in developing world, study says

TUESDAY, June 17 (HealthDay News) -- A new compound that may lead to an inexpensive, easy-to-take treatment for diarrhea has been discovered by researchers at the University of Texas Health Science Center at Houston.

This finding may prove especially important for developing countries, where diarrhea is a major cause of child deaths. Diarrhea kills an estimated 1.6 million to 2.5 million children a year, according to information published by the World Health Organization.

The new compound -- a pyridopyrimidine derivative -- targets E. coli and other enterotoxigenic strains of bacteria that cause acute secretory diarrhea. These bacteria produce toxins that stimulate the linings of the intestines, causing them to secrete excessive fluid, resulting in diarrhea.

In preclinical tests on animals infected with diarrhea-causing bacteria, the new compound was associated with a significant reduction in intestinal fluid secretion. The compound also reduced fluid build-up in laboratory tests on human cells. There was no indication of toxicity caused by the compound.

The research was published in the June 16 online edition of the journal Proceedings of the National Academy of Sciences.

"While this research looks extremely promising as a preventive or therapeutic intervention in Third World diarrheal disease and traveler's diarrhea, much work remains to be done to move into clinical trials and eventual therapeutic approval," study senior author Dr. Ferid Murad cautioned in a prepared statement.

A drug based on this compound may also prove effective in treating inflammatory bowel disease and some endocrine disorders, Murad said.

The discovery of this compound is "a promising lead," said Dr. Stanley G. Schultz, a cellular signaling expert at the University of Texas Medical School at Houston who was not involved in the study.

"An inexpensive drug that could block the intestinal secretory pathway, with minimal side effects, would be a 'magic bullet' that would not only save millions of lives in many parts of the developing world, but would also save the billions of dollars that are lost annually because of diarrhea throughout the world. It would truly be a treatment of diarrhea rather than a treatment of the consequences of diarrhea," Schultz said in a prepared statement.

Currently, there is no effective way to directly treat secretory diarrhea. Treatment is aimed at minimizing fluid loss through intravenous or oral rehydration.

More information

The American College of Gastroenterology has more about diarrheal diseases.



-- Robert Preidt



SOURCE: University of Texas Health Science Center at Houston, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel
2. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
3. Inexpensive Online Pain Education Program for Physicians as Effective as Live Presentations by National Experts
4. UCR chemists use green chemistry to produce amines, chemical compounds used widely in industry
5. Telik Announces Patents on Compounds Related to TELINTRA
6. New PA Economic Study: Bush Medicare Cuts Compound State Medicaid Crisis
7. Red Wine Compound Helps Heart, May Slow Aging
8. New Compound Slows HIV Replication
9. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
10. Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol
11. Grapefruit Compound Inhibits Hepatitis C Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... August 16, 2017 , ... Blue Health Intelligence (BHI) ... Chief Medical Officer. Dr. Spiro brings over 30 years of clinical, healthcare IT, value-based ... BHI’s cutting-edge analytics solutions. , “I am thrilled to welcome Dr. Spiro to ...
(Date:8/16/2017)... ... August 16, 2017 , ... Any Lab Test Now® ... company ranked #4429 on the newly released, 36th annual Inc. 5000 , the ... look at the most successful companies within the American economy’s most dynamic segment — ...
(Date:8/16/2017)... ... August 16, 2017 , ... Modern Consulting Insurance & Financial ... Partnering once again with Boys & Girls Clubs of Greater Kansas City, the ... very own American Idol. With all proceeds benefitting local worthy causes, donations may ...
(Date:8/16/2017)... ... August 16, 2017 , ... A global leader in ... opened clubfoot clinics in all 29 Indian states—bringing the country one step closer to ... Himachal Pradesh, the nonprofit organization is on track to enroll 10,000 children in the ...
(Date:8/16/2017)... ... 16, 2017 , ... Harbor Retirement Associates (HRA), a regional ... two of their associates were recognized with individual “Best of the Best” awards ... Florida. The awards were announced at the 5th Annual 2017 Conference, held in ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
(Date:7/31/2017)... TORONTO , July 31, 2017 7D Surgical, ... Spartan Medical has purchased the 7D Surgical System to support ... Washington D.C. and Virginia.  7D Surgical ... Medical for many of the premier medical facilities within those ... ...
(Date:7/26/2017)... , July 26, 2017 E.I. Medical Imaging ... the Bimini SharkLab to custom design the worlds first ultrasound system ... sharks in their native habitat. In preparation for a ... Channel,s Shark Week, Dr. Guttridge approached EIMI with the ... diagnosis directly to hammerhead sharks underwater. ...
Breaking Medicine Technology: