Navigation Links
Individual mutations are very slow to promote tumor growth
Date:9/28/2010

CAMBRIDGE, Mass., Sept. 28, 2010 -- Individual cancer-causing mutations have a minute effect on tumor growth, increasing the rate of cell division by just 0.4 percent on average, according to new mathematical modeling by scientists at Harvard University, Johns Hopkins University, and other institutions.

Their research, appearing this week in the Proceedings of the National Academy of Sciences, reinforces that cancer is the culmination of many accumulated mutations. It also highlights the fundamental heterogeneity and randomness of many cancers, consistent with the observations of epidemiologists and clinicians.

"This work suggests that significant tumor growth probably requires the slow and steady accumulation of multiple mutations in a cell over a number of years," says lead author Ivana Bozic, a doctoral student in Harvard's Department of Mathematics and Program for Evolutionary Dynamics. "It also helps explain why so many cancer-driving mutations are needed to form an advanced malignancy within the lifetime of an individual."

All of our cells undergo regular division and death, processes that ordinarily balance out each other. In cancer this balance is broken, leading to invasive tumors that crowd out healthy cells and spread in the body.

"While emerging data from the sequencing of cancer genomes are illuminating, their reconciliation with epidemiological and clinical observations poses a major challenge," Bozic says. "Our novel mathematical model begins to address this disconnect."

Bozic's work adds to scientists' recent efforts to differentiate between "driver" and "passenger" mutations in tumors. Researchers have found that most solid tumors contain 40 to 100 mutations in coding genes, but that on average only 5 to 15 of these actually drive tumor growth. The remainder are simply along for the ride: associated with driver mutations, but not benefiting the tumor.

Tumors begin growing with the f
'/>"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bacteria identified that may lead to inflammatory bowel disease in certain individuals
2. For migrant workers, community cooperation builds on individual strengths
3. Lung cancer survival rates improved through use of individualized chemotherapy
4. Rectal cancer rates are rising in young individuals
5. Children have a negative impact on physical activity among individuals with heart disease
6. Individuals confess alcohol abuse to clergy
7. Brain responses of obese individuals are more weakly linked to feelings of hunger
8. New research shows peer drug use may increase an individuals genetic tendency to use drugs
9. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
10. Educate individuals to prevent sky-rocketing health care costs
11. Tai Sophia Institute Offers Individual Graduate-Level Courses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 BESLER Consulting , ... services for hospitals, is pleased to announce that it ... of America’s Fastest-Growing Companies. The list represents the most ... independent entrepreneurs. , "It's been an exciting year ... included in this year's Inc. 5000 list,” said Jonathan ...
(Date:8/27/2014)... designed to help regulate the blood,s iron supply shows promise ... to results from the first human study of ... , the Journal of the American Society of Hematology ... blood cells are in short supply or do not function ... get enough oxygen, since there are fewer red blood cells ...
(Date:8/27/2014)... State University,s Center for Leadership in Disability (CLD) ... Maternal and Child Health Bureau of the Health ... the Autism Plan for Georgia, aimed at improving ... disorder. , In preparing for this project, CLD ... key stakeholders from across Georgia. The resulting plan ...
(Date:8/27/2014)... Cash House 's contributions to Horizons ... upkeep of the shelter including new initiatives and a wide ... the lives of each youth who walk through their door. ... for youth ages 16-25. Not only does Horizons operate as ... for the youth who come through their doors. Horizons has ...
(Date:8/27/2014)... Houston, TX (PRWEB) August 27, 2014 ... The reality is that depression has a mortality ... those with bi-polar disorder is slightly less, though it's ... of roughly 7%. In order to properly treat ... schizophrenia, and bi-polar, medication must be taken as directed. ...
Breaking Medicine News(10 mins):Health News:BESLER Consulting Among America’s Fastest Growing Private Companies 2Health News:Drug represents first potential treatment for common anemia 2Health News:Cash House a Major Supporter of Horizons for Youth 2Health News:Cash House a Major Supporter of Horizons for Youth 3Health News:MedicationDiscountCard.com now Makes Brintellix and Mental Illness Medications More Affordable with Discount Cards 2
... that even in young neurons it is the survival of ... off// depends on its ability to establish connections with other ... Fred H. Gage, Ph.D., a professor in the Gene Expression ... on Age-Related Neurodegenerative Diseases. It says that a subunit of ...
... with prostate cancer and their spouses/significant others are being ... Los Angeles-area medical centers as part of a// collaborative ... Prostate cancer is the most common form of cancer ... Prostate Cancer Center at the Samuel Oschin Comprehensive Cancer ...
... to stress and the absence of disease rather than ... the fields of neurobiology// and psychoneuroendocrinology. And healthy aging ... along with adopting an active, healthy lifestyle. This finding ... the American Psychological Association (APA). ,From a ...
... Pinij Jarusombat, said on Sunday that a total of 46 ... under close medical// supervision. ,The minister visited two ... on Sunday afternoon. A total of 46 patients in ... kept under close medical supervision. ,The new outbreak ...
... breast biopsy has successfully removed the lesion by taking ... lesion, a new study// shows. ,“Contrast-enhanced MRI ... with lesions that cannot be detected with other techniques,” ... the University of Texas M.D. Anderson Cancer Center in ...
... AIDS began here with calls for a long-term strategy to defeat ... Joint United Nations Programme on HIV and AIDS (UNAIDS) said Sunday ... the start of the 16th International AIDS Conference. ,As ... was time to attack the root causes of the problem in ...
Cached Medicine News:Health News:Fittest Of Newborn Neurons Survive 2Health News:Fittest Of Newborn Neurons Survive 3Health News:Prostate Cancer Patients Sought for Database as Part of Joint Effort 2Health News:Prostate Cancer Patients Sought for Database as Part of Joint Effort 3Health News:Wear and Tear of Stress: The Psychoneurobiology of Aging 2Health News:Wear and Tear of Stress: The Psychoneurobiology of Aging 3Health News:Specimen Radiography Confirms Success of MRI-Guided Breast Biopsy 2Health News:Global AIDS Conference Calls for Long-term Strategies 2
(Date:8/27/2014)... 27, 2014 Decision Resources Group finds that ... Memphis health system and hospital sector ... with rivals Methodist Le Bonheur Healthcare and Baptist Memorial ... coordinate patient care. In addition, a national contract recently ... health plan enrollment in the Memphis ...
(Date:8/27/2014)... , Aug. 27, 2014 ISPE , ... it has released a preview of its Drug ... industry avoid drug shortages and maintain a robust and ... The Plan, a first for the industry, was ... industry members and describes how industry can best prevent ...
(Date:8/27/2014)... Conn. , Aug. 27, 2014 Pulse ... Record (EHR) , Practice Management , and Revenue ... little known business practices performed by some RCM vendors, at ... Philadelphia, PA on September 19-20, 2014.  ... Systems will return in September with a new session encouraging ...
Breaking Medicine Technology:Memphis-area Health Systems Turn Attention to Clinical Integration 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 3ISPE Releases First Look at its Plan to Prevent Drug Shortages 4Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 2Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 4
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
12 mm diameter pigtail curved probes with eyes 4mm back of blunt ends. Stainless steel. Round knurled handle with polished finish. Overall length: 5.9 inches....
The Novus 2000 argon laser combines power, size, and versatility. Ideal for the office, clinic and operating room environments, Novus 2000 is the world's most widely accepted ophthalmic laser....
The VISULAS 532s combines ease of use, efficiency and safety to provide ophthalmologists with an overall system sharply focused on their requirements. ,The VISULAS 532s is a laser of many talent...
Medicine Products: