Navigation Links
Individual mutations are very slow to promote tumor growth
Date:9/28/2010

CAMBRIDGE, Mass., Sept. 28, 2010 -- Individual cancer-causing mutations have a minute effect on tumor growth, increasing the rate of cell division by just 0.4 percent on average, according to new mathematical modeling by scientists at Harvard University, Johns Hopkins University, and other institutions.

Their research, appearing this week in the Proceedings of the National Academy of Sciences, reinforces that cancer is the culmination of many accumulated mutations. It also highlights the fundamental heterogeneity and randomness of many cancers, consistent with the observations of epidemiologists and clinicians.

"This work suggests that significant tumor growth probably requires the slow and steady accumulation of multiple mutations in a cell over a number of years," says lead author Ivana Bozic, a doctoral student in Harvard's Department of Mathematics and Program for Evolutionary Dynamics. "It also helps explain why so many cancer-driving mutations are needed to form an advanced malignancy within the lifetime of an individual."

All of our cells undergo regular division and death, processes that ordinarily balance out each other. In cancer this balance is broken, leading to invasive tumors that crowd out healthy cells and spread in the body.

"While emerging data from the sequencing of cancer genomes are illuminating, their reconciliation with epidemiological and clinical observations poses a major challenge," Bozic says. "Our novel mathematical model begins to address this disconnect."

Bozic's work adds to scientists' recent efforts to differentiate between "driver" and "passenger" mutations in tumors. Researchers have found that most solid tumors contain 40 to 100 mutations in coding genes, but that on average only 5 to 15 of these actually drive tumor growth. The remainder are simply along for the ride: associated with driver mutations, but not benefiting the tumor.

Tumors begin growing with the f
'/>"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bacteria identified that may lead to inflammatory bowel disease in certain individuals
2. For migrant workers, community cooperation builds on individual strengths
3. Lung cancer survival rates improved through use of individualized chemotherapy
4. Rectal cancer rates are rising in young individuals
5. Children have a negative impact on physical activity among individuals with heart disease
6. Individuals confess alcohol abuse to clergy
7. Brain responses of obese individuals are more weakly linked to feelings of hunger
8. New research shows peer drug use may increase an individuals genetic tendency to use drugs
9. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
10. Educate individuals to prevent sky-rocketing health care costs
11. Tai Sophia Institute Offers Individual Graduate-Level Courses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... The Residential Senior Care Franchises ... years. The industry, which provides residential and personal-care services ... for themselves, has boomed on account of the aging ... seniors with memory impairment. As a result, IBISWorld expects ... 4.1% to $1.9 billion over the five years to ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post explaining ... caused by a car accident. , Car insurance ... A policy can pay for car repairs and even ... carry appropriate coverage when they are driving. ... several important riders that offer extra coverage options. One ...
(Date:4/18/2015)... Carinsurancehints.com has released a new blog post explaining how ... protection against fire damage. , Clients can now find ... vehicle is set intentionally on fire. This type of damages ... other things. , It is possible to compare the ... http://www.carinsurancehints.com/ , in just a few minutes. Clients should ...
(Date:4/18/2015)... PITTSBURGH, PA (PRWEB) April 18, 2015 ... so I decided to create a healthful juice ... an inventor from Rosedale, Md. "It increases my ... overall healthy body." , He developed Tapp's Juice ... The juice helps to prevent physical and mental ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Insuranceautoquote.info has ... online auto insurance quotes . , Clients ... a single website. The online environment provides important advantages ... vehicles. , Drivers who do not have coverage ... rates during any season, day or hour. Many agencies ...
Breaking Medicine News(10 mins):Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2
... Veterinary Medical,Association (AVMA) today cited the release of ... Inspector General (OIG) report on pre-slaughter,activities in U.S. ... of,food animal veterinarians,( http://www.avma.org/press/releases/080208_nvmsa.asp ) can have dire,consequences ... The OIG report, which was released ...
... access from Internet fraud, Vetted International has implemented a higher level ... ... Raleigh, NC (PRWEB) December xx, 2008 --- Vetted Internationals ... from web fraud . An application upgrade to its ...
... says lack of exposure could also perpetuate more allergies ... Peanut and other food allergies are on the rise, ... life-threatening allergies, and schools are responding by providing nut-free ... schools are going too far, even creating hysteria over ...
... Obama,Administration sets its sights on stabilizing and strengthening ... today called on the transition,team and incoming Treasury ... where action by the Treasury Department is needed ... alcohol content,per serving and the definition of moderate, ...
... than 200 underprivileged,children in Detroit will receive new winter jackets ... annual Holiday Party presented by the Wayne County,Medical Society Foundation ... The New Detroit Science Center at 5020 John R at ... Physicians, medical students, physician spouses and staff ...
... Mich.Dec. 12 The Michigan Legislature,took an important step ... yesterday,by passing House Bill 4146, according to the Michigan ... The bill, introduced by Rep. Frank Accavitti (D-Eastpointe), regulates,tanning ... 18, larger warning signs in tanning facilities listing potential ...
Cached Medicine News:Health News:AVMA Calls for Increased Veterinary Oversight in Meat Production; Cites USDA Audit Report Initiated After Hallmark/Westland Recall 2Health News:AVMA Calls for Increased Veterinary Oversight in Meat Production; Cites USDA Audit Report Initiated After Hallmark/Westland Recall 3Health News:To Further Combat Internet Fraud, Heightened Security Levels are Implemented by Vetted International 2Health News:To Further Combat Internet Fraud, Heightened Security Levels are Implemented by Vetted International 3Health News:Nut Bans in Schools May Be Spurring Hysteria 2Health News:Nut Bans in Schools May Be Spurring Hysteria 3Health News:Consumer/Health Groups Call for Meaningful Change in How Treasury Department Regulates Alcohol Labeling 2Health News:Consumer/Health Groups Call for Meaningful Change in How Treasury Department Regulates Alcohol Labeling 3Health News:Consumer/Health Groups Call for Meaningful Change in How Treasury Department Regulates Alcohol Labeling 4Health News:Consumer/Health Groups Call for Meaningful Change in How Treasury Department Regulates Alcohol Labeling 5Health News:Consumer/Health Groups Call for Meaningful Change in How Treasury Department Regulates Alcohol Labeling 6Health News:Dermatologists Applaud Passage of Tanning Salon Regulation 2
(Date:4/17/2015)... RALEIGH, N.C. , April 17, 2015 /PRNewswire/ ... of the Integrated Embolic Protection™ filter platform for ... completion of a $5.6 million Series B financing ... stage venture firm with a focus on medical ... medicine. The round also included Mountain Group Partners, ...
(Date:4/17/2015)... 2015 LifeScienceIndustryResearch.com announces having ... on Global and China Lysine Industry to its ... and the deep research report in this field. ... information including definition, classification specifications, application, industry chain ... Europe , Japan ...
(Date:4/17/2015)... April 17, 2015 CVS Health Corporation (NYSE: ... on Friday, May 1, 2015, at 8:30 a.m. (EDT) ... financial results. An audio webcast of the ... Relations portion of the CVS Health website for all ... . This webcast will be archived and available on ...
Breaking Medicine Technology:Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 3Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5
... 2011 ULURU Inc. (NYSE AMEX: ... of a portfolio of wound management and oral care products, ... NYSE Amex (the "Exchange"), dated December 5, 2011, indicating that ... granted the Company an extension until March 21, 2013 to ...
... CardioMEMS announced today that the U.S. Food and Drug ... the Champion Heart Failure Monitoring System, the first wireless, ... failure patients from their homes.  While the panel agreed ... of 9-1, the majority did not vote positively that ...
Cached Medicine Technology:ULURU Inc. Receives Notice From NYSE Amex Regarding Continued Listing Standards 2ULURU Inc. Receives Notice From NYSE Amex Regarding Continued Listing Standards 3FDA Advisory Panel Recommends Against Approval of Champion® Heart Failure Management System for Patients With Heart Failure 2FDA Advisory Panel Recommends Against Approval of Champion® Heart Failure Management System for Patients With Heart Failure 3
... a 22 kD, 191 amino acid, polypeptide hormone ... pituitary. The hGH gene contains five exons and ... a gene family. The hGH ELISA is used ... into the cell culture supernatant of eukaryotic cells ...
... is a high-throughput immunoassay system built around ... 2000 with the important addition of Logic ... to be designed for optimal performance with ... for critical assays such as the cardiac ...
... IMMULITE 2000 assays ... with the IMMULITE 2000, ... access immunoassay analyzer. IMMULITE ... through centralization, and a ...
... and IMMULITE 1000 assays are ... IMMULITE and IMMULITE 1000, continuous ... offer simplicity in both design ... be found in a wide ...
Medicine Products: