Navigation Links
Individual gene differences can be tested in zebrafish
Date:10/25/2012

HERSHEY, Pa. -- The zebrafish is a potential tool for testing one class of unique individual genetic differences found in humans, and may yield information helpful for the emerging field of personalized medicine, according to a team led by Penn State College of Medicine scientists. The differences, or mutations, in question create minor changes in amino acids -- the building blocks of DNA -- from person to person. Zebrafish can be used as a model to understand what biological effects result from these genetic mutations.

Personalized medicine uses modern technology and tools to find biological and genetic differences in individuals so that treatment is more effectively delivered.

"A major challenge of personalized medicine is the lack of a standard way to define the importance of each of the many unique mutations found in an individual's genetic code," said Keith Cheng, M.D., Ph.D., professor of pathology and lead researcher. "Approaches are particularly needed to experimentally determine what differences these mutations make. It is difficult to distinguish the effects of a single amino acid change caused by those changes in our DNA."

The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo and the powerful genetic tools available in this model organism.

The Cheng lab's approach is like testing small damages in car parts, one at a time. For example, a "mutant" car headlight is known not to work when a certain connector is missing. Taking a normally functioning connector out of a working headlight and replacing it with a connector damaged in a specific way -- a cracked wire casing or a corroded wire connector, for example -- can show whether the damage matters. If the light works, then that mutation makes no difference on the function of the headlight. If the light does not work, the mutation has an effect.

Postdoctoral fellow Zurab Tsetskhladze, who perform
'/>"/>

Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Restricting high-risk individuals from owning guns saves lives
2. Normal weight individuals with belly fat at highest CVD risk
3. Individualized care best for lymphedema patients, MU researcher says
4. In Massachusetts, individual mandate led to decreased hospital productivity
5. Neuroeconomics to study decision-making in anxious individuals
6. Lax gun ownership laws could impact ability of high-risk individuals to purchase firearms
7. Device converting images into music helps individuals without vision reach for objects in space
8. Mesothelioma Victims Center Now Urges US Navy Veterans Or Individuals With Mesothelioma To Call Them For The Names Of The Best Mesothelioma Attorneys & Treatment Options
9. Mesothelioma Victims Center Now Offers A US Navy Veteran Individual Or Family Dealing With Mesothelioma The Names Of The Best Mesothelioma Attorneys--Quality Matters
10. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
11. Personalizing biologic treatment to individual patients with rheuatoid arthritis is cost-effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... 28, 2015 One in three young ... research presented today at the American Orthopaedic Society for ... examined the long term success of surgery for patients ... survey data from 242 patients who underwent ACL reconstruction ... Roe, MBBS, FRACS, from North Sydney Orthopaedic and Sports ...
(Date:3/28/2015)... NV (PRWEB) March 28, 2015 Delaying ... not be necessary, according to research presented today at ... ) Specialty Day. , “Our study compared results for ... who underwent an additional glenohumeral joint capsule release procedure ... George Murrell MD, PhD, lead author from St. George ...
(Date:3/28/2015)... 28, 2015 Genomic medicine experts have ... revealing, for the first time, key information for understanding ... read the newly posted story on the Surviving ... of British Columbia, the British Columbia Cancer Agency, and ... reveal underlying molecular alterations and mutations that can lead ...
(Date:3/28/2015)... OR (PRWEB) March 28, 2015 Lately ... the media regarding recent changes and proposals around the ... , current and former collegiate student-athletes across a spectrum ... and reflect on common challenges. The special panel consists ... country in sports ranging from football, track and field, ...
(Date:3/28/2015)... 2015 Healthpointe’s otolaryngologists, medical practitioners who ... disorders, are now offering a wide variety of ... is characterized by the presence of phantom sounds or ... tinnitus is a prevalent symptom that can arise due ... non-fatal, tinnitus can impede a person’s quality of life. ...
Breaking Medicine News(10 mins):Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:New Genomics Research May Help Doctors Tailor Mesothelioma Treatment, According to Surviving Mesothelioma 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2
... In the blink of an eye, people at risk ... diseases such as diabetic retinopathy and age-related macular degeneration. ... of Energy,s Oak Ridge National Laboratory to understand semiconductor ... digital cameras that take pictures of the retina. Those ...
... This release is available in French . ... drug addicts at medically supervised clinics does not pose ... by Serge Brochu, a researcher at the Universit de ... leg of the NAOMI project, otherwise know as the ...
... Recovery and Investment Act of 2009 by Congress, the ... Specter of Pennsylvania for his leadership in including a ... (NIH). , "Senator Specter has demonstrated a long-standing ... the fight against cancer," said Margaret Foti, Ph.D., M.D. ...
... CHICAGO --- The kids who pass through juvenile detention facilities ... do they fare a few years after this significant brush ... University,s Feinberg School of Medicine interviewed youths ages 13 to ... Detention Center to see how they were doing three years ...
... Feb. 17 The State Commander of the Indiana ... a "slap in the face" to supporters of the ... Daniels."At his (Governor Daniels,) request to our Department Adjutant, ... alternative to simply shutting down the Home, and what ...
... similar to verbal communication, Nicaraguan study shows , , TUESDAY, Feb. ... own language-like gesture systems that expand in the same way ... , That,s the finding from a University of Chicago researcher ... , "Since 1996, I have been working with deaf adolescents ...
Cached Medicine News:Health News:ORNL, UT project could save vision of millions 2Health News:ORNL, UT project could save vision of millions 3Health News:Medical prescription of heroin does not pose neighborhood risk 2Health News:American Association for Cancer Research lauds Senator Arlen Specter 2Health News:Troubled youths struggle after time in detention center 2Health News:Legion Condemns Governor's Non-Response to ISSCH Proposal As 'Slap In The Face' 2Health News:Deaf Children Can Create Own Sign Language 2
(Date:3/27/2015)... , March 27, 2015  Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces the reporting of data from ... Hydrochloride for Injection with the Delcath Hepatic Delivery ... presentation at the Society of Surgical Oncology (SSO) ...
(Date:3/26/2015)... 2015  The Burzynski Research Institute, Inc. (BRI) announced ... by the Department of Surgery at Kurume University ... have been published. The study, a randomized non-blinded ... as post-operative adjuvant therapy with and without Antineoplastons ... A total of 65 patients, ...
(Date:3/26/2015)... March 26, 2015 "Whether it,s our family, ... day." In a single sentence, Dr. ... officer at Pfizer,s Centers for Therapeutic Innovation ... fueling progress at America,s biopharmaceutical companies. ... with academia, patient foundations and the National Institutes of ...
Breaking Medicine Technology:Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 2Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 4Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 5Collaboration for Cures: Teaming Up to Advance Science and Save Lives 2
... Biotech scientists increasingly are applying genomics technologies to ... drug candidates on a variety of organ systems, reports ... ). They are especially interested in figuring out a ... predictive toxicology technique, according to the November 15 issue ...
... NeuroDiscovery Ltd (ASX:,NDL), a specialty neuroscience service ... Corporation ("Sosei"; TSE Mothers Index: 4565), a ... presenting further pivotal pre-clinical efficacy data for ... for neuropathic pain and has,successfully completed Phase ...
Cached Medicine Technology:GEN Reports on the Trend Toward Predictive Toxicogenomics 2Sosei and NeuroSolutions Present Further Data on NSL-043/SD118 at the Society for Neuroscience 38th Annual Meeting 2Sosei and NeuroSolutions Present Further Data on NSL-043/SD118 at the Society for Neuroscience 38th Annual Meeting 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: