Navigation Links
Individual Genome Changes Over a Lifetime
Date:6/24/2008

Finding suggests dietary, environmental exposures may explain 'late onset' diseases

TUESDAY, June 24 (HealthDay News) -- A new finding about the chemical, or epigenetic, marks on an individual's DNA sequence may explain why people become more susceptible to disease as they age and why the health of one's genes is similar among families.

Researchers at Johns Hopkins University, reporting in the June 25 issue of the Journal of the American Medical Association, found that certain types of epigenetic marks change during a person's lifetime and the amount of change is similar among related people.

"We're beginning to see that epigenetics stands at the center of modern medicine, because epigenetic changes, unlike DNA sequence which is the same in every cell, can occur as a result of dietary and other environmental exposure," Dr. Andrew P. Feinberg, director of the Epigenetics Center at the Johns Hopkins School of Medicine, said in a prepared statement. "Epigenetics might very well play a role in diseases like diabetes, autism and cancer."

Researchers found in one study that methylation -- a specific type of epigenetic mark that can contribute to disease if levels are off -- changed over an 11-year period in a third of the 600 people whose DNA was studied. In some, the levels increased; in others, it decreased.

"What we saw was a detectable change over time, which showed us proof of the principle that an individual's epigenetics does change with age," M. Daniele Fallin, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, said in a prepared statement. "What we still didn't know was why or how, but we thought 'maybe this, too, is something that's heritable' and could explain why certain families are more susceptible to certain diseases."

In a second study, the team studied 126 people from two- and three-generation families over a 16-year period and found that the methylation changes tended to be similar among family members: if one's levels dropped over time, for example, a similar decrease occurred in other family members.

"We still haven't concretely figured out what this means for health and disease, but as an epidemiologist, I think this is very interesting, since epigenetic changes could be an important link between environment, aging and genetic risk for disease," Fallin said.

More information

The U.S. National Library of Medicine has more about DNA.



-- Kevin McKeever



SOURCE: Johns Hopkins University, news release, June 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Laser surgery probe targets individual cancer cells
2. Blue Cross and Blue Shield of Georgia Introduces New Individual Products
3. WellPoint Appoints Raj G. Bal as President of Individual Business
4. Every patient is unique: Individualized therapies for non-Hodgkins lymphoma
5. Utah Schools Leading the Nation in Adopting Technology to Manage Individual Student Achievement
6. Depression diversity: Brain studies reveal big differences among individuals
7. PA Department of Health Urges Sexually Active Individuals in Delaware County to Get STD Tests
8. Bayada Nurses Advocates for Increase in Medicaid Reimbursement Rate to Allow More Individuals to Receive Home Care and Hire More Skilled Staff
9. Bayada Nurses Schedule Tuesday News Conference to Address Need for Increased Medicaid Reimbursement to Enable Home Health Care Organizations to Treat More Individuals
10. Bernard A. Krooks From the Special Needs Alliance to Talk Tax Strategies for Individuals With Disabilities Tomorrow on Good Morning America NOW
11. LA Career Coach Unveils LifeStage Methodology to Help Individuals Make Effective Work-Life Choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... 21, 2017 , ... The Margarian Law Firm has filed a class ... ale for allegedly containing no ginger. Dr. Pepper produces the “Canada Dry” brand of ... Margaryan alleges Canada Dry Ginger Ale claims on its bottle that it is made ...
(Date:7/21/2017)... ... July 21, 2017 , ... “Kids aren't born knowing how to ... shoes,” says Suzanne Tucker, Founder of St. Louis-based positive education company Generation Mindful. To ... Kickstarter on Monday, July 21st. , The kit uses colorful, engaging and educational ...
(Date:7/21/2017)... CANADA (PRWEB) , ... July 21, 2017 , ... ... torn anterior cruciate ligament (ACL) offer patients improved quality of life five years ... for Sports Medicine’s Annual Meeting in Toronto, Ontario, Canada. The study followed ...
(Date:7/20/2017)... Boston, MA (PRWEB) , ... July 20, 2017 ... ... aggressive form of blood and bone marrow cancer that progresses rapidly without treatment. ... often recommended to reduce the chance of reoccurrence and relapse. With such ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... in which their iMedSecure™ comes included with each system installation. RMT’s iMedHD2™ ... to remote participants for real-time collaboration and immediate decision-making requirements. While never ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... 2017  New York City-based market research firm Kalorama Information ... aware of.  From new products to new costs, to the ... recently completed study, Potential Pipeline Disruptors . ... 1.  Age-Driven Growth - True Impact Moment Arriving ... the impact the growing population and, to a more extreme ...
(Date:7/11/2017)... ROCKVILLE, Md. , July 11, 2017  The ... had estimated revenues of approximately $394.1 million in 2016.  ... a trend of solid growth, in particular as a ... oncology clinical practice, and the recent introduction of a ... the need for less-invasive testing of tumor biomarkers to ...
(Date:7/10/2017)... GAITHERSBURG, Md. , July 10, 2017 ... in non-animal test methods, is the recipient of a ... by the PETA International Science Consortium. The device, which ... be used to expose human lung cells to airborne ... lung. IIVS will use the VITROCELL® system for testing ...
Breaking Medicine Technology: