Navigation Links
Individual Genome Changes Over a Lifetime
Date:6/24/2008

Finding suggests dietary, environmental exposures may explain 'late onset' diseases

TUESDAY, June 24 (HealthDay News) -- A new finding about the chemical, or epigenetic, marks on an individual's DNA sequence may explain why people become more susceptible to disease as they age and why the health of one's genes is similar among families.

Researchers at Johns Hopkins University, reporting in the June 25 issue of the Journal of the American Medical Association, found that certain types of epigenetic marks change during a person's lifetime and the amount of change is similar among related people.

"We're beginning to see that epigenetics stands at the center of modern medicine, because epigenetic changes, unlike DNA sequence which is the same in every cell, can occur as a result of dietary and other environmental exposure," Dr. Andrew P. Feinberg, director of the Epigenetics Center at the Johns Hopkins School of Medicine, said in a prepared statement. "Epigenetics might very well play a role in diseases like diabetes, autism and cancer."

Researchers found in one study that methylation -- a specific type of epigenetic mark that can contribute to disease if levels are off -- changed over an 11-year period in a third of the 600 people whose DNA was studied. In some, the levels increased; in others, it decreased.

"What we saw was a detectable change over time, which showed us proof of the principle that an individual's epigenetics does change with age," M. Daniele Fallin, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, said in a prepared statement. "What we still didn't know was why or how, but we thought 'maybe this, too, is something that's heritable' and could explain why certain families are more susceptible to certain diseases."

In a second study, the team studied 126 people from two- and three-generation families over a 16-year period and found that the methylation changes tended to be similar among family members: if one's levels dropped over time, for example, a similar decrease occurred in other family members.

"We still haven't concretely figured out what this means for health and disease, but as an epidemiologist, I think this is very interesting, since epigenetic changes could be an important link between environment, aging and genetic risk for disease," Fallin said.

More information

The U.S. National Library of Medicine has more about DNA.



-- Kevin McKeever



SOURCE: Johns Hopkins University, news release, June 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Laser surgery probe targets individual cancer cells
2. Blue Cross and Blue Shield of Georgia Introduces New Individual Products
3. WellPoint Appoints Raj G. Bal as President of Individual Business
4. Every patient is unique: Individualized therapies for non-Hodgkins lymphoma
5. Utah Schools Leading the Nation in Adopting Technology to Manage Individual Student Achievement
6. Depression diversity: Brain studies reveal big differences among individuals
7. PA Department of Health Urges Sexually Active Individuals in Delaware County to Get STD Tests
8. Bayada Nurses Advocates for Increase in Medicaid Reimbursement Rate to Allow More Individuals to Receive Home Care and Hire More Skilled Staff
9. Bayada Nurses Schedule Tuesday News Conference to Address Need for Increased Medicaid Reimbursement to Enable Home Health Care Organizations to Treat More Individuals
10. Bernard A. Krooks From the Special Needs Alliance to Talk Tax Strategies for Individuals With Disabilities Tomorrow on Good Morning America NOW
11. LA Career Coach Unveils LifeStage Methodology to Help Individuals Make Effective Work-Life Choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... International Protein, ... nutritional and bodybuilding supplements, announced it attended the January ECRM trade show in Hilton ... and nutritional scientist who was determined to create a line of products that would ...
(Date:1/20/2017)... ... , ... “Mary Magdalene: Grace is Greater than Sin”: a unique and ... Christ firsthand. “Mary Magdalene: Grace is Greater than Sin” is the creation of published ... with countless women who had little knowledge of the female characters portrayed in the ...
(Date:1/20/2017)... Farmville, NC (PRWEB) , ... January 20, 2017 ... ... the vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in ... article by Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive ...
(Date:1/20/2017)... ... 20, 2017 , ... “The Land of More and More”: a brilliant ... hunger, and shares the simple and achievable answer. “The Land of More and More” ... Fairview Missionary Church in Angola, Indiana where he works with the children’s ministry department. ...
(Date:1/19/2017)... ... 19, 2017 , ... Next week after January 20th, the fear for many ... that circumvent health needs of over 30 million. Many interviews with Dr. Carol Francis ... government public servants were suppose to prioritize. Interviews provided below. , Among ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
(Date:1/19/2017)... January 19, 2017 According to a study ... is set to witness a CAGR of 6.5% during the forecast ... will continue to be the leading market for cryotherapy globally ... ... emphasizing on ensuring affordable and adequate supply of gas in order ...
Breaking Medicine Technology: