Navigation Links
Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment
Date:3/28/2011

Researchers at Mount Sinai School of Medicine have found that patients with Alzheimer's disease have lower glucose utilization in the brain than those with normal cognitive function, and that those decreased levels may be detectable approximately 20 years prior to the first symptoms of Alzheimer's disease. This new finding could lead to the development of novel therapies to prevent the eventual onset of Alzheimer's. The study is published online in the journal Translational Neuroscience.

Using mice modified to develop Alzheimer's disease, the research team found that when β-amyloid, an abnormal protein linked to Alzheimer's disease, starts to become detectable in the brain in its soluble toxic form, the mitochondria, or "power plants" of the cell where glucose is converted into energy, became impaired. Within the equivalent of about 20 human years, mice with decreased energy metabolism developed signs of Alzheimer's disease such as cognitive defects and impairment of the synaptic terminal, the area of brain cells important in memory formation.

"This evidence in mice validates that the diagnosis of probable Alzheimer's disease may be the end result of impairment in brain cell energy production," said the study's lead author, Giulio M. Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry, Geriatrics, and Adult Development at Mount Sinai School of Medicine. "Identifying that mitochondrial impairment is evident years earlier than cognitive defects is a major breakthrough."

"This new evidence could revolutionize the way we design interventions," said Merina T. Varghese, MD, co-author of the study and Postdoctoral Fellow in Neurology at Mount Sinai School of Medicine. "This study sets the stage for the development of potential novel preventions or therapies to apply in humans, even when they have normal cognitive function, to prevent the eventual onset of Alzheimer's disease."


'/>"/>

Contact: Jeanne Bernard
Jeanne.Bernard@MountSinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Early indications of Parkinsons disease revealed in dream sleep
2. Study finds changes in incidence of end-stage renal disease from lupus nephritis
3. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
4. Load up on fiber now, avoid heart disease later
5. Study examines whether lower blood pressure reduces kidney disease progression
6. Study Ties Asthma to Higher Odds for Diabetes, Heart Disease
7. Chemistry of Mosquito Sex May Hold Key to Disease Control
8. Doctors should evaluate liver disease patients for cognitive impairment, address driving safety
9. New blood analysis chip could lead to disease diagnosis in minutes
10. Bilingual neurons may reveal the secrets of brain disease
11. Sirolimus therapy alleviates symptoms of lung disease LAM
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... VA (PRWEB) , ... June 23, 2017 , ... ... of what is needed and will ultimately do significant harm to people with ... to everyone. , "While it leaves in place the Affordable Care Act ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... cooking is essential, and two new videos highlight the importance of correctly using ... Christine Bruhn, Ph.D., who has done extensive research on consumer food safety habits. ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance ... With the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more ... 2012, the Biggert-Waters Act was enacted to reflect the actual risk in flood ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency that offers ... Texas, is announcing the launch of a new charity drive to benefit women in ... United States reveal that an estimated 252, 710 new cases of invasive or high ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... 1, 2017 Nutriceutical Holdings (NH), parent company ... (VRS), and KD Pharma Group have decided to join ... KD Pharma Group. KD Pharma Group will become the ... acquire the entire company. "We believe we ... committed to growing the NH companies by providing us ...
(Date:5/26/2017)... 26, 2017  Endo International plc (NASDAQ: ENDP ... CEO, will represent the Company in a fireside chat at ... Tuesday, June 13, 2017 at 10:40 a.m. PT / 1:40 ... in Rancho Palos Verdes, CA. ... will be available on the Company,s website at http://www.endo.com/investors/overview ...
(Date:5/22/2017)...  As the specialty pharmacy industry and the ... the revolutionary shift from volume-based to value-based care, ... patient outcomes and shaping the future of the ... from clinical trials and toward data that reveals ... therapy utilization in precise patient populations. Therigy ® ...
Breaking Medicine Technology: