Navigation Links
Indication of considerable added benefit of vemurafenib in advanced melanoma
Date:1/8/2013

The drug vemurafenib (trade name Zelboraf) has been approved since February 2012 for the treatment of advanced melanoma (cancer of the skin cells that produce the dark pigment, melanin). It can be an option for adults whose melanoma cannot be removed by surgery or has formed secondaries (metastases) and in whose cancer a change (mutation) has occurred in a certain gene (BRAF-V600). The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG). According to the findings, major advantages in terms of overall survival are accompanied by major potential harm in the form of side effects. Overall, there is an indication that vemurafenib offers considerable added benefit.

Vemurafenib in comparison with dacarbazine

The Federal Joint Committee (G-BA) has specified the drug dacarbazine as the appropriate comparator therapy. One study that compared vemurafenib directly with dacarbazine was available for the benefit assessment. This is a randomized and open-label study, i.e. patients were randomly assigned to one of the two treatment groups and both they and their doctors knew which of the two drugs was used in each case.

Longer survival means major added benefit

IQWiG always assesses a drug with a view to patient-relevant outcomes such as survival (mortality), symptoms and complications (morbidity) as well as quality of life. The study provides an indication that vemurafenib can prolong life. While half of the patients who received dacarbazine died after less than 10 months, in the vemurafenib group this was the case only after more than 13 months. The differing course of the two survival curves provides an indication of a major added benefit of vemurafenib.

Pain was the only outcome recorded in the study in relation to morbidity. There were, however, no statistically significant diff
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antibody-coated stents: Indication of disadvantages
2. Abiraterone: Indication of considerable added benefit in certain patients
3. Considerable added benefit of ipilimumab in advanced melanoma
4. Marketing Xocolate International Corporation (MXI-Corp) Introduces Xe Healthy Energy Drink, A Rich And Delicious Antioxidant Beverage, Now Added to Xoçai™ Product Line
5. Capsiplex Plus Reviews for Improved Weight Loss Supplement Added to BestAppetiteSuppressantPills.com
6. UV-Aid Cold and Flu Prevention Added to List of Biomimicry Strategies on AskNature.Org
7. Healthy Chocolate Omega Squares, a Decedent Dark Chocolate Added to Marketing Xocolate International Corporation (MXI Corp) Product Lines
8. Rilpivirine for HIV: Added benefit for single agent proven
9. US Drug Watchdog Has Added Wright, Stryker, Biomet, and Zimmer To Their Initiative For All Metal Hip Implant Failures Victims & Offers Them The Names Of The Best Lawyers
10. CFO 911 Solutions' Charles K. Dargan II, CEO, and Reid Dabney, Managing Director Have Been Added to the Financial Entrepreneur Platform ("FEP") of Merriman Capital, Inc., a Wholly Owned Subsidiary of Merriman Holdings, Inc. (OTCQX: MERR)
11. Vandetanib in thyroid cancer: No proof of added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... and sound may be bad for your waistline. TV ... watching an excerpt from a Hollywood action film than ... been blamed for helping Americans to gain weight because ... why has been on the medium and not the ... cause people to eat more, including reading, listening to ...
(Date:9/1/2014)... (HealthDay News) -- You may be able to convince your ... research suggests. The study included eight overweight and obese ... meant to change how people react to different foods. These ... and obese people who weren,t in the program. Both ... study and again six months later. The scans revealed that ...
(Date:9/1/2014)... New York (PRWEB) September 01, 2014 ... room in a hospital for performing surgical operations. An ... as operating tables, surgical booms, operating room lights, imaging ... According to a report by Transparency Market Research, a ... is expected to reach USD 4.5 billion by 2019. ...
(Date:9/1/2014)... HealthDay Reporter FRIDAY, Aug. ... given to two American aid workers successfully cured a group ... researchers report. The drug, ZMapp, prompted recovery in all ... the medication until five days after infection. ZMapp even ... or even hours away from death, said study senior author ...
(Date:9/1/2014)... 01, 2014 The National Association of ... that Dawn Bazarko, DNP, MPH, RN, and Adriana Perez, ... American Academy of Nursing. They will be inducted with ... FACHE, whose induction we reported last May. , Our ... during the 2014 American Academy of Nursing Policy Conference ...
Breaking Medicine News(10 mins):Health News:Research letter: Viewers ate more while watching Hollywood action flick on TV 2Health News:Train Your Brain to Choose Fruit Salad Over French Fries 2Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 2Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 3Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 2Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4
... might be associated with a one third reduction in ... published on bmj.com today. The findings confirm ... potential beneficial link between chocolate consumption and heart health. ... to test whether chocolate actually causes this reduction or ...
... San Francisco, CA The 2011 Annual Meeting & OTO ... Neck Surgery Foundation (AAO-HNSF), the largest meeting of ear, nose, ... 2011, in San Francisco, CA. Featuring more than 386 ... hours for attendees, the annual meeting is a unique opportunity ...
... blood vessels is mostly done the same way today ... the French surgeon Alexis Carrel won a Nobel Prize for ... Stanford University School of Medicine has developed a sutureless method ... In animal studies, a team led by Stanford microsurgeon ...
... The death rate among patients prescribed a statin in a ... those given a placebo, even though most participants in both ... Cardiac Outcomes Trial, was stopped early because the statin was ... new analysis has shown that eight years on, the most ...
... pacing on implantable cardioverter-defibrillator (ICD) patient survival is ... mitigated by cardiac resynchronization therapy (CRT), based on ... society of Cardiology (ESC) Congress Aug 28 in ... the average patient, despite having severe left ventricular ...
... 27 (HealthDay News) -- As another school year begins, ... books and other supplies can lead to back injury. ... to time. They often carry much more than they ... unnecessary items," Dr. Joshua Hyman, director of orthopedic surgery ...
Cached Medicine News:Health News:It's official -- chocolate linked to heart health 2Health News:2011 AAO-HNSF poster presentations 2Health News:2011 AAO-HNSF poster presentations 3Health News:2011 AAO-HNSF poster presentations 4Health News:2011 AAO-HNSF poster presentations 5Health News:2011 AAO-HNSF poster presentations 6Health News:2011 AAO-HNSF poster presentations 7Health News:2011 AAO-HNSF poster presentations 8Health News:2011 AAO-HNSF poster presentations 9Health News:2011 AAO-HNSF poster presentations 10Health News:2011 AAO-HNSF poster presentations 11Health News:2011 AAO-HNSF poster presentations 12Health News:2011 AAO-HNSF poster presentations 13Health News:2011 AAO-HNSF poster presentations 14Health News:2011 AAO-HNSF poster presentations 15Health News:2011 AAO-HNSF poster presentations 16Health News:2011 AAO-HNSF poster presentations 17Health News:2011 AAO-HNSF poster presentations 18Health News:2011 AAO-HNSF poster presentations 19Health News:2011 AAO-HNSF poster presentations 20Health News:2011 AAO-HNSF poster presentations 21Health News:Stanford researchers invent sutureless method for joining blood vessels 2Health News:Stanford researchers invent sutureless method for joining blood vessels 3Health News:Stanford researchers invent sutureless method for joining blood vessels 4Health News:Statins reduce deaths from infection and respiratory illness, 8 years on from trial 2Health News:Patients are living longer with ICDs, but pacing impacts survival rates 2
(Date:8/29/2014)... Aug. 29, 2014   Vittamed Corporation , a neurodiagnostics ... announced today that T. (Teo) Forcht Dagi , MD, ... Board of Directors. " Teo Forcht Dagi ... neurosurgery, medical innovation and venture capital," said Remis Bistras ... to add his clinical, strategic, and entrepreneurial expertise to our ...
(Date:8/29/2014)... /PRNewswire-iReach/ -- ChemImage will present a workshop focused on ... Forensic Science Society,s 22 nd International Symposium ... Australia .  Forensic Scientists will be in ... imaging can bring to examination procedures. ... Product Development at ChemImage, will host a workshop ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014  Pacific Medical ... its new website design . The main website, ... that showcases the company,s new services and content relevant ... implementing a new streamlined design, viewers can now better ... for health care practices and create a more visible ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3PMDS Announces New Website 2
... Nov. 20 Medco Health Solutions, Inc (NYSE: ... healthcare through an advanced, wired pharmacy paradigm that is already ... curve downward -- making medicine smarter for the benefit of ... the elements in its strategy enable "Smarter Medicine" to help ...
... , NEW YORK, ... a new market research report is available in ... Analysis and Forecasts to 2015 , ... , India Medical Equipment Market Analysis and Forecasts ...
Cached Medicine Technology:Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 2Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 3Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 4Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 5Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 2Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 3Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 4Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 5Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 6Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 7Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 8Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 9Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 10Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 11Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 12Reportlinker Adds India Medical Equipment Market Analysis and Forecasts to 2015 13
Infant Nebulizer Kit W/Misty-Nebulizer 30/CS CE Mark Only...
... Suggested Clinical Applications:, ,Cool Aerosol Therapy. ... open system devices such as aerosol masks, ... that provide only limited FIO2 and limited ... Nebulizer guards against accidental dilution with room ...
... new PARI TREK™ Compact Compressor is for ... aerosol treatments anywhere and everywhere. The compressor ... versatile power source optionsworldwide AC compatibility (100 ... battery, permit patients the freedom to take ...
... ,Allied Healthcares Timeter® PCS 414 portable air ... compressors that you may wonder if its running. ... features a durable, mar-resistant steel case thats easy ... only 26.5 pounds. The PCS 414 has been ...
Medicine Products: