Navigation Links
Indian plant could play key role in death of cancer cells
Date:2/14/2013

AUGUSTA, Ga. Scientists at the Georgia Regents University Cancer Center have identified an Indian plant, used for centuries to treat inflammation, fever and malaria, that could help kill cancer cells.

Cancer cells typically avoid death by hijacking molecular chaperones that guide and protect the proteins that ensure normal cellular function and then tricking them into helping mutated versions of those proteins stay alive, says Dr. Ahmed Chadli, a researcher in the Molecular Chaperone Program at the GRU Cancer Center and senior author of the study named the Journal of Biological Chemistry's Paper of the Week.

Drug development has focused on the chaperone Hsp90 (heat shock protein 90) because it plays a key role in assisting mutated proteins, making it an attractive cancer drug target. However, the clinical efficacy of Hsp90 inhibitors has been disappointing. Most current small molecules targeting Hsp90 have inadvertently resulted in the expression of proteins that protect cancer cells from programmed cell death and compromise the Hsp90 inhibitors in the clinic.

In this study, however, Chaitanya Patwardhan, a graduate student in Dr. Chadli's lab, found that gedunin, an Indian plant compound, attacks a co-chaperone, or helper protein, of Hsp90 called p23.

"This compound binds directly to p23, leading to inactivation of the Hsp90 machinewithout production of anti-apoptotic proteinsthus killing cancer cells," said Dr. Chadli. "The idea here is that this will open a door for new ways of targeting Hsp90 by targeting its helper proteins, which may be used in combination with established Hsp90 inhibitors that are ongoing clinical trials. In the future, this research could have applications in drug development for hormone-dependent cancers, including breast, prostate and endometrial cancers."

"One of the major areas of scientific emphasis of the GRU Cancer Center is to develop therapeutic approaches to cancer
'/>"/>

Contact: Danielle Moores
dwongmoores@yahoo.com
706-496-5956
Georgia Health Sciences University
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. American Indian spiritual beliefs influential in spurring youth to avoid drugs and alcohol
2. Top Canadian, Indian institutions form $30M partnership
3. Cost Per Workers’ Compensation Claim Rising In Indiana As Payments for Medical Care Increase, Says New WCRI Study
4. Best Drug Rehabilitation's New Indiana Facility to Create Dozens of Quality Long-Term Jobs
5. Central Brace & Limb of Indiana Fits Patient with a Michelangelo Myoelectric Hand Prosthesis
6. Malecare Announces a New LGBT Cancer Survivor Support Group in Indianapolis Indiana
7. Indiana network for patient care helps officials track disease, warn of outbreaks
8. Westminster Pediatrician Residents Love Encourages Flu Shots for the Whole Family at Indian Crest Pediatrics
9. American Indians at Heightened Risk for Suicide After Heavy Drinking
10. UTHealth research shows American Indians at greater risk of suicide after alcohol intoxication
11. Discovery could help to develop drugs for organ transplant and cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Indian plant could play key role in death of cancer cells
(Date:5/20/2013)... 2013) - A new "telerehabilitation" approach lets physical therapists ... Internet, with good accuracy compared with face-to-face examinations, reports ... Spine . The journal is published ... of Wolters Kluwer Health . , Taking advantage ... a more feasible alternative to in-person clinic visits, according ...
(Date:5/20/2013)... May 20, 2013 Medicare Part D ... satisfied, citing lower costs, convenient access to pharmacies and ... Research Associates released today by the Pharmaceutical Care Management ... (9.5 million) are currently enrolled in plans with preferred ... and overall value of plans with preferred pharmacy networks,” ...
(Date:5/20/2013)... 2013 Cliff Lake Dental Care is pleased to ... schedules when visiting the dentist office . The change was ... schedule. , Here are the new office hours: Mondays- 8 a.m. ... 8 a.m. to 1 p.m. and 2-5 p.m., Thursdays 7 a.m. ... will be open to take appointments only. Cliff Lake Dental wants ...
(Date:5/20/2013)... 20, 2013 A pioneer and ... solutions, i2i Systems announced today that ... Foundation (SCF) selected i2iTracks as their population management ... meet their Meaningful Use (MU), Government Performance and ... requirements – a welcomed solution to managing the ...
(Date:5/20/2013)... May 20, 2013 Selexis SA, a ... identification and cell line development for scale-up and manufacturing ... co-founder will present data on the Company’s core technology ... Engineering Conference, May 20 - 23 at the Hyatt ... Selexis’ co-founder and scientific advisory board member, Nicolas Mermod, ...
Breaking Medicine News(10 mins):Health News:Telerehabilitation allows accurate assessment of patients with low back pain 2Health News:Telerehabilitation allows accurate assessment of patients with low back pain 3Health News:Survey: 85% of Part D Seniors in Preferred Pharmacy Plans are Satisfied With Costs, Pharmacy Choices 2Health News:Cliff Lake Dental Care Announces Office Hours Change 2Health News:Baldrige Award Winner Southcentral Foundation Selects i2iTracks Population Health Intelligence Solution to Support Meaningful Use, GPRA and UDS Reporting Requirements 2Health News:Baldrige Award Winner Southcentral Foundation Selects i2iTracks Population Health Intelligence Solution to Support Meaningful Use, GPRA and UDS Reporting Requirements 3Health News:Selexis SA to Present Technology Platform Data at Cell Line Development & Engineering 2Health News:Selexis SA to Present Technology Platform Data at Cell Line Development & Engineering 3
... new but today there is a growing industry catering to ... National Guard Sgt. Darrell "J.R." Salzman has learned to tie ... shiny metal hook that serves as his right called Utah ... myoelectric Utah Arm, made by Motion Control Inc., of Salt ...
... number of doctors in Portugal were refusing to carry out ... the 10th week of pregnancy . ,The law ... at least nine public hospitals out of a total of ... approved the law in March after a February referendum found ...
... Asbestos Saskatchewan committee, the Canadian Cancer Society's call for a ... is welcomed news and reflects a changing environment. ,"Obviously ... Canada of public interests and social justice organizations to put ... political agenda, Sass was quoted.,"Up to now it has not ...
... will build a 60-acre health and education complex in Islamabad ... people of the capital and the twin city of Rawalpindi ... residential development plan to develop a Health and Education City ... colleges of medicine, nursing, and dentistry. ,Harvard ...
... A new study has found that divorce, not shared genetic ... to the higher rates of break-ups experienced by the offspring ... study to look at genetics as a reason in the ... found that the parents' divorce itself, played a key role ...
... of children ages 5 to 7,C-reactive protein, a marker ... disease, may also indicate cognitive impairment in children ... OSA have increased levels of hsCRP [high-sensitivty C-reactive protein] ... David Gozal, M.D., of the University of Louisville in ...
Cached Medicine News:Health News:War Stimulates Research Blitz in Prosthetics Industry 2Health News:Move To Ban Asbestos Welcomed 2Health News:Genetics is Not the Reason for Family Break-ups 2Health News:C -reactive Protein is the Marker for Cardiovascular Disease 2
(Date:5/20/2013)... ALEXANDRIA, Va. , May 20, 2013   ... B. Douglas Hoey , RPh, MBA issued the ... Hart Research Associates regarding Medicare Part D "preferred ... pharmacies from offering patients the plan,s lowest advertised co-payments: ... "Officials with Medicare and MedPAC , ...
(Date:5/20/2013)... MAPLE GROVE, Minn. , May 20, 2013 ... committed to the development of new treatments for ... the launch of its newly designed website, ... through images and narratives.  As part of the ... – our new branding campaign centers around people ...
(Date:5/20/2013)... 20, 2013 /PRNewswire-iReach/ -- Today at American Society ... Christine Ginocchio discussed Specific Technologies blood ... identification of microorganisms producing bloodstream infection. Dr. Ginocchio ... the Division of Infectious Disease Diagnostics at North ... non-sectarian health system. (Photo: http://photos.prnewswire.com/prnh/20130520/CG16829 ...
Breaking Medicine Technology:Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 2Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 3Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 4Upsher-Smith Introduces Newly Redesigned Corporate Website 2Specific Technologies Bloodstream Infection Identification Solutions Discussed at the American Society for Microbiology Conference by Award Lecturer Christine Ginocchio 2Specific Technologies Bloodstream Infection Identification Solutions Discussed at the American Society for Microbiology Conference by Award Lecturer Christine Ginocchio 3
... -- Global Information, Inc. (GII) is pleased to announce ... Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017" by ... The Insulin Delivery Devices Market is Set to Grow ... 2017 GlobalData estimated the global insulin ...
... N.C., Jan. 13, 2012  Facing patent cliffs and shrinking ... either through in-licensing deals or M&A activities - as ... sound strategy, but a difficult one to effectively put ... a business is fraught with potential pitfalls. With 2012 ...
Cached Medicine Technology:Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 2Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 3Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 4Excellence Services Program Delivers a Road Map to Successfully Guide the Pharmaceutical Industry Through the New Alliance Landscape 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: