Navigation Links
Indian plant could play key role in death of cancer cells
Date:2/14/2013

AUGUSTA, Ga. Scientists at the Georgia Regents University Cancer Center have identified an Indian plant, used for centuries to treat inflammation, fever and malaria, that could help kill cancer cells.

Cancer cells typically avoid death by hijacking molecular chaperones that guide and protect the proteins that ensure normal cellular function and then tricking them into helping mutated versions of those proteins stay alive, says Dr. Ahmed Chadli, a researcher in the Molecular Chaperone Program at the GRU Cancer Center and senior author of the study named the Journal of Biological Chemistry's Paper of the Week.

Drug development has focused on the chaperone Hsp90 (heat shock protein 90) because it plays a key role in assisting mutated proteins, making it an attractive cancer drug target. However, the clinical efficacy of Hsp90 inhibitors has been disappointing. Most current small molecules targeting Hsp90 have inadvertently resulted in the expression of proteins that protect cancer cells from programmed cell death and compromise the Hsp90 inhibitors in the clinic.

In this study, however, Chaitanya Patwardhan, a graduate student in Dr. Chadli's lab, found that gedunin, an Indian plant compound, attacks a co-chaperone, or helper protein, of Hsp90 called p23.

"This compound binds directly to p23, leading to inactivation of the Hsp90 machinewithout production of anti-apoptotic proteinsthus killing cancer cells," said Dr. Chadli. "The idea here is that this will open a door for new ways of targeting Hsp90 by targeting its helper proteins, which may be used in combination with established Hsp90 inhibitors that are ongoing clinical trials. In the future, this research could have applications in drug development for hormone-dependent cancers, including breast, prostate and endometrial cancers."

"One of the major areas of scientific emphasis of the GRU Cancer Center is to develop therapeutic approaches to cancer
'/>"/>

Contact: Danielle Moores
dwongmoores@yahoo.com
706-496-5956
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. American Indian spiritual beliefs influential in spurring youth to avoid drugs and alcohol
2. Top Canadian, Indian institutions form $30M partnership
3. Cost Per Workers’ Compensation Claim Rising In Indiana As Payments for Medical Care Increase, Says New WCRI Study
4. Best Drug Rehabilitation's New Indiana Facility to Create Dozens of Quality Long-Term Jobs
5. Central Brace & Limb of Indiana Fits Patient with a Michelangelo Myoelectric Hand Prosthesis
6. Malecare Announces a New LGBT Cancer Survivor Support Group in Indianapolis Indiana
7. Indiana network for patient care helps officials track disease, warn of outbreaks
8. Westminster Pediatrician Residents Love Encourages Flu Shots for the Whole Family at Indian Crest Pediatrics
9. American Indians at Heightened Risk for Suicide After Heavy Drinking
10. UTHealth research shows American Indians at greater risk of suicide after alcohol intoxication
11. Discovery could help to develop drugs for organ transplant and cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Indian plant could play key role in death of cancer cells
(Date:4/17/2014)... the most popular vaccine brands for children may not ... overlooking some cost factors when choosing vaccines, driving the ... according to a new study by University of Illinois ... be driven by numerous factors," says Sheldon H. Jacobson, ... computer science and of mathematics at the U. of ...
(Date:4/17/2014)... issue of Experimental Biology and Medicine ... Gaskins and Paul Kenis in the Institute of ... University of Illinois Urbana-Champaign describe their recent work ... a variety of cell functions including energy metabolism, ... roles in regulating normal cellular behavior, redox status ...
(Date:4/17/2014)... recent papers by a University of Colorado School ... develop treatments or vaccines for Dengue fever, West ... disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, associate ... School of Medicine and an early career scientist ... recently published articles in the scholarly journals ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2
... BEER-SHEVA, ISRAEL, December 17, 2010 As middle ear ... University of the Negev (BGU) suggest that in many ... instead of using antibiotics immediately. The review, published ... Therapy , does not suggest use of watchful waiting ...
... -- Differences in immune signaling pathways among various species ... primates to certain infectious diseases, researchers say. For ... to AIDS or severe complications from hepatitis B, it ... chimpanzees to the serious effects of these viral infections, ...
... News) Christmas and other winter holidays are supposed to ... the more stressful when they are anything but joyous. ... especially vulnerable to depression, Dr. Angelos Halaris, a psychiatrist with ... release. Shopping and entertaining can be stressful, while reflecting on ...
... research indicates that about half of women age 65 and ... place, the poverty rate for women falls to 12 percent. ... are presented in the latest installment of the Public ... on an Aging Society, the public policy branch of The ...
... THURSDAY, Dec. 16 (HealthDay News) -- U.S. scientists have unraveled ... cancer in children. Gene sequencing reveals that this tumor, ... adult tumors. The discovery that MB has five to ... attempts to understand what triggers the cancer and which treatment ...
... , , , , , ... , AUDIO: People with a known risk ... Click here for more information. , , ... , , , , , ...
Cached Medicine News:Health News:Ben-Gurion U. researchers: High resistance rates among acute otitis media pathogens in children 2Health News:Primate Immune System Differences Identified 2Health News:Surviving the Holiday Blues 2Health News:Brief clarifies Social Security's value for women 2Health News:Gene Research Brings Insight Into Deadly Childhood Brain Tumor 2Health News:MRI scans reveal brain changes in people at genetic risk for Alzheimer's 2Health News:MRI scans reveal brain changes in people at genetic risk for Alzheimer's 3Health News:MRI scans reveal brain changes in people at genetic risk for Alzheimer's 4Health News:MRI scans reveal brain changes in people at genetic risk for Alzheimer's 5
(Date:1/15/2014)... , Jan. 15, 2014 Tegra Medical is very pleased ... as its new Chief Executive Officer.  Mark was promoted ... he has overseen the company,s four facilities in ... Rica.  Mr. King joined Tegra Medical in 2012 with 20+ ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium Research ... market intelligence, the United States ... device markets will expand moderately through 2022, with ... In particular, increasing interest in drug-eluting beads (DEBs) ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ...
Breaking Medicine Technology:Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... YORK, Jan. 19, 2012 Berkery Noyes, an independent ... Year Mergers and Acquisitions trend report for ... The report analyzes the sector ... 2009 and 2010. This market includes information and technology ...
... Associates is among just five workplaces to appear on ... For" since the rankings debuted three decades ago.  The ... earned the No. 38 spot on the 2012 list, ... ) Headquartered in Newark, Del., Gore employs ...
Cached Medicine Technology:Berkery Noyes Releases 2011 Pharma & Healthcare Information and Technology Industry Mergers & Acquisitions Report 2Berkery Noyes Releases 2011 Pharma & Healthcare Information and Technology Industry Mergers & Acquisitions Report 3W. L. Gore & Associates Named a Top U.S. Workplace 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: