Navigation Links
Increased risk of relapse omitting RT in early PET scan negative Hodgkin lymphoma
Date:3/19/2014

Interim analysis of the intergroup EORTC-LYSA-FIL 20051 H10 trial published in the Journal of Clinical Oncology indicates an increased risk of early relapse when omitting radiotherapy in early PET scan negative patients with stage I/II Hodgkin's lymphoma. Early outcome, however, was excellent in both arms, and the final analysis should reveal whether these initial findings are maintained over time.

Dr. J.M.M. Raemaekers of the Radboud university medical center Nijmegen, The Netherlands, and central coordinator of the study says, "The standard treatment for patients with clinical stage I/II Hodgkin's Lymphoma is ABVD (adriamycin, bleomycin, vinblastin and dacarbazin) chemotherapy followed by radiotherapy. Striking the right balance between initial cure through combined modality treatment and accepting a higher risk of late complications, and a higher recurrence rate after omitting radiotherapy in subsets of patients who will subsequently need intensive salvage treatment, is a matter of unsettled debate."

The main objective of the H10 trial was to evaluate whether involved-node radiotherapy could be omitted without loss of efficacy in terms of progression-free survival in patients with stage I/II Hodgkin's Lymphoma who had a negative earlyPET scan after two cycles of ABVD chemotherapy. This interim trial analysis included a total of 1137 patients with untreated clinical stage I/II Hodgkin's Lymphoma. Of these, 444 patients had favorable and 693 unfavorable prognoses. Patients in each prognostic group were randomized between standard and experimental treatment and first received two cycles of ABVD chemotherapy. Patients in the experimental arm who attained a negative earlyPET scan after the two cycles of ABVD chemotherapy were spared involved-node radiotherapy.

For patients with a favorable prognosis and a negative earlyPET scan, one progression occurred in the standard arm and nine progressions occurred in the experimental arm. F
'/>"/>

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gestational diabetes linked to increased risk for heart disease in midlife
2. Despite recession, childrens health spending increased between 2009-2012, says new report
3. Death of partner associated with increased risk of heart attack, stroke
4. Smoking linked with increased risk of most common type of breast cancer
5. New clues may link hereditary cancer genes to increased risk of cancer from alcohol
6. Patients with multiple sclerosis in Taiwan may be at increased risk of developing cancer
7. Increased risk of prostate cancer in African-American men; implications for PSA screening
8. No brakes -- Study finds mechanism for increased activity of oncogene in certain cancers
9. Hospital-diagnosed maternal infections linked to increased autism risk
10. Local Campaign to Educate African American Women on Increased Risk of Breast Cancer
11. In Light of Increased Levels of Personal Stress Over the Holiday Season, Lanahan Insurance Recommends Staying Covered with Health Insurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Johnson & Johnson and its ... lawsuit ( http://www.risperdallawsuit2014.com/ ) settlement with a California ... use of the antipsychotic medication. According to court ... third bellwether trial to involve male breast growth ... Pennsylvania’s Philadelphia Court of Common Pleas, where more ...
(Date:5/29/2015)... May 29, 2015 A group of doctors ... joined the national effort to teach this “new math” to ... U.S. have been “sickened” by the recent implementation of Common ... or hate it, Common Core is now a reality in ... Parents are now seeking ways to improve common core ...
(Date:5/29/2015)... FL (PRWEB) May 29, 2015 ... Utah, recently partnered with Stratus Video ... which will facilitate better communication and timely ... (LEP) and hearing loss. Stratus’ video remote ... in-house translators, enabling staff to quickly access ...
(Date:5/29/2015)... 29, 2015 The print component of ... circulation of approximately 250,000 and an estimated readership of ... vast social media strategy, and across a network of ... digital version of the campaign, click here. ... publication. Inside, the actress, model and producer details her ...
(Date:5/29/2015)... New York, NY (PRWEB) May 29, 2015 ... readers on the “beauty of protection”. Skin Health ... through USA Today within the markets of New York, ... reach an estimated 750,000 readers. Its digital counterpart will ... online content hubs. To read more the Skin Health ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 2Health News:Risperdal Lawsuit Selected as Pennsylvania’s Third Bellwether Gynecomastia Case Settles Hours Before Trial 3Health News:Doctors Discover a Cure for the Common Core 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4Health News:Mediaplanet Launches “Skin Health” Campaign Featuring Colorescience 2
... According to a new study it is observed that ... effects for adults diagnosed with bacterial meningitis. Dexamethasone is ... patients.// The death rate among adults diagnosed with bacterial ... pneumonia. Researchers from the Academic Medical Center in Amsterdam ...
... to a new study researchers observe that stress hormones ... HPA (hypothalamus-pituitary-adrenal) axis is a hormonal system that helps ... end result is the production of the stress hormone ... is characterized by aches, pains and overwhelming tiredness. It's ...
... that a new topical medication can effectively treat signs of ... that in a long-term study of tazarotene cream, has ... 55 percent// of those tested, and it continued to show ... radiation from the sun is known to have numerous ill ...
... University observed that a chest compression belt outperforms manual ... someone has a cardiac arrest, it's vital to get ... as possible. Usually this is done by applying chest ... but these are usually not available in those vital ...
... in University of Boston observe that brain imaging sheds new ... apnoea, a person stops breathing, momentarily, many times during the ... at the back of the throat, causing upper airway obstruction. ... daytime sleepiness. It may also be a risk factor for ...
... emphysema does not help the sickest patients, according to ... lungs - the alveoli - are progressively destroyed,// leaving ... do everyday activities like climbing stairs or carrying their ... lung reduction surgery was beneficial for people with emphysema. ...
Cached Medicine News:
(Date:5/29/2015)... MENLO PARK, Calif. , May 29, ... (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical ... therapies in new orphan drug indications, presented additional ... Cancer Research (AACR) Advances in Brain Cancer Research ... product candidate VAL-083 (dianhydrogalactitol) to treat ...
(Date:5/29/2015)... 2015 Educating the community continues to ... the Advancement of Wound Care (AAWC), which was ... AAWC,s corporate partners, the Association provides medical professionals ... AAWC website at http://aawconline.org/education-for-the-generalist/ . The portal ... links to various CME/CEU educational programs. This education ...
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Companies"  to their offering.  ... (RNAi) or gene silencing involves the use ... the cell, this material is processed into ...
Breaking Medicine Technology:DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 4DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 5The Association for the Advancement of Wound Care Educates the Public 2Global RNAi Market Report 2015-2024 - Technologies, Markets and Companies 2Global RNAi Market Report 2015-2024 - Technologies, Markets and Companies 3
... N.Y., July 17 Strong National,Museum of Play ... of the,American Journal of Play, the first interdisciplinary ... The inaugural issue enters the scholarly scene ... the most prominent national,researchers and writers in the ...
... to data from other, technologies -, ... Bradmer Pharmaceuticals Inc.,(TSX: BMR), a biopharmaceutical company dedicated ... released progression free,survival (PFS) data from two previously ... (GBM) patients. As an exploratory,endpoint of the single ...
Cached Medicine Technology:Groundbreaking American Journal of Play from Strong National Museum of Play(R) Premiers July 2008 2Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials 2Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials 3Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials 4Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: