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Increased risk of developing lung cancer after radiotherapy for breast cancer
Date:4/6/2014

ts showed that the risk of developing a radiation-induced second lung cancer was approximately one in every 200 women treated with postoperative radiotherapy. "In the current study, we wanted to see if there was a dose-response correlation for second primary lung cancer after breast cancer irradiation. We further wished to estimate the excess relative risk per delivered Gray to the lung. As smoking is strongly correlated to lung cancer, we also looked into the effect of radiation and smoking," explained Dr Grantzau.

The researchers retrieved radiotherapy records of the previous breast cancer radiation treatment (including the delivered dose, field size and treatment technique) together with the smoking status for all cases and controls. For the cases they also obtained radiographic images of the lung cancers. With this information they were able to reconstruct the ways that the women had been treated for the original breast cancer and to estimate the amount of radiation that was delivered to the part of the lung where the subsequent tumour developed. They tested the accuracy of their calculated radiation doses on a model, or "phantom", and made adjustments to take into account the higher doses that they found were actually delivered to areas outside the main field of radiation.

The median age of the women when they were diagnosed with breast cancer was 54 (with a range of 34-74) and the median age when a second primary lung cancer was diagnosed was 68 (range 46-90). Seventy percent of the lung cancers were diagnosed five or more years after radiotherapy for breast cancer, ranging from five to 26 years. The majority (91%) of the lung cancer cases were smokers, whereas 40% of the controls were smokers.

The mean average dose of radiotherapy during breast cancer treatment that had been delivered to the site of the lung tumour was 8.7 Gy, while it was 5.6 Gy to the comparable site in the women who had not developed lung cancer. Although the a
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Contact: Emma Mason
wordmason@mac.com
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

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