Navigation Links
Increased level of magnetic iron oxides found in Alzheimer's disease
Date:3/12/2008

A team of scientists, led by Professor Jon Dobson, of Keele University in Staffordshire, UK, have found, for the first time, raised levels of magnetic iron oxides in the part of the brain affected by Alzheimer's Disease (AD).

Their research has also shown that this association was particularly strong in females compared to males. The group speculates that this may be a result of gender differences in the way the body handles and stores iron.

Though the results are based on a small number of samples, they give an indication that iron accumulation associated with Alzheimer's appears to involve the formation of strongly magnetic iron compounds. As these compounds have a strong effect on MRI signal intensity, with further study, it may be possible to use this as a biomarker for the development of an MRI-based Alzheimer's diagnostic technique.

The research team also included Quentin Pankhurst, London Centre for Nanotechnology and Department of Physics & Astronomy, University College, London; Dimitri Hautot, Institute of Science and Technology in Medicine, Keele University, and Nadeem Khan, Department of Neuropathology, Institute of Psychiatry, King's College London.

The study looked at brain tissue from 11 Alzheimers Disease and 11 age-matched control subjects. It showed, for the first time, that the total concentration of biogenic magnetite is generally higher in the Alzheimer brain (in some cases as much as 15 times greater than controls) and that there are gender-based differences, with Alzheimers Disease with female subjects having significantly higher concentrations than all other groups.

Professor Dobson said: Iron accumulation and dysregulation of iron transport and storage has been found to be associated with many other neurodegenerative conditions, such as Parkinsons disease, Huntingtons disease (HD), multiple sclerosis and Amyotrophic Lateral Sclerosis. In recent years, a hereditary neurodegenerative disease, neuroferritinopathy, has been linked to a mutation in the gene encoding for the ferritn light polypeptide. This direct link between neurodegeneration in the basal ganglia and ferritin, the bodys primary iron storage protein, results in the accumulation of iron in the brain and symptoms similar to HD.

There is still little known about the chemical form of iron associated with these diseases, its role in neurodegeneration (if any) and its origin. Investigations of brain iron based on histochemical staining techniques have generally ignored its chemical state.

This study shows a clear correlation in the concentration and the size of the biogenic magnetite in both the Alzheimer disease and control groups. It is also notable that the largest magnetite concentrations and smallest particles are all from Alzheimer disease subjects, and that the data from the control subjects follow the same trend. This implies that the genesis of the biogenic magnetite may be the same in all cases, but that in Alzheimer Disease it may be more indicative of an accelerated process.

Professor Dobson added: We speculate that magnetite formation within the ferritin core may occur generally in the brain, perhaps associated with aging, and that the process may become abnormal and uncontrolled in the Alzheimer brain. At this stage, this should be considered a working hypothesis and needs to be examined in larger studies. It appears, however, that elevated levels of magnetic iron oxides, which include reactive Fe2+, are present in AD tissue, a finding that lends weight to the suggestion that redox-active iron may play a role in neurodegenerative disease."


'/>"/>

Contact: Chris Stone
press@keele.ac.uk
44-178-258-3375
IOS Press
Source:Eurekalert

Related medicine news :

1. Increased distance to physician associated with thicker skin cancer at diagnosis
2. Methamphetamine study suggests increased risk for HIV transmission
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Minorities more likely to have sleep durations associated with increased mortality
5. Teens who see more smoking in movies may have increased risk of becoming established smokers
6. Study shows adverse drug events reported to the FDA have significantly increased
7. New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction
8. Maternal depression and controlling behavior associated with increased stress response in infants
9. BioProcessors Launches SimCell(TM) Services to Meet Increased Customer Demand
10. Both short and long sleep is associated with increased mortality
11. New Study Shows Lower Costs, Increased Consumer Engagement in Account-Based Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Boston, MA (PRWEB) , ... May 03, 2016 , ... Registration is now open for ... Sunday, June 5, 2016 at the Hatch Memorial Shell on the Esplanade. The event regularly ... 6.2-miles. The 5K Run is a competitive, timed event fully sanctioned by the USA Track ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Elizabeth Murray ... pet parrots to join her with one on her shoulder and one on her ... a parking lot because of years of mitral valve prolapse. , The valves of ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... ... today announced that it is launching a new client service center in La ... Houston, Texas, and will provide the full range of Empyrean client services. , ...
(Date:5/3/2016)... ... , ... Ogawa World USA introduced the first of its kind Ogawa ... Application. The Smart 3D combines the best in technological advancement, design, and massage capability ... specialized massage program, each user has a tailored experience unparalleled by any other massage ...
(Date:5/3/2016)... ... May 03, 2016 , ... Dr. Poneh Ghasri, cosmetic dentist in West ... new and existing patients. Cosmetic dentistry allows patients to improve the aesthetics of their ... with some minor or more serious cosmetic flaws. These specials allow patients to achieve ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... PROVO, Utah , May 3, 2016  Forté Elements, LLC (Forté) is excited ... use nutritional products that address the nutritional needs of recovery for a variety of ... its products. Photo - http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
(Date:5/3/2016)... , May 3, 2016 ... heute bekannt, dass sie einen entscheidenden Meilenstein ... haben: Ein Aufruf zum Handeln, um Patientenresultate ... Veröffentlichung trägt zu Fortschritten im Verständnis der ... hervor, ein Bewusstsein für Hepatische Enzephalopathie in ...
(Date:5/2/2016)... NEW YORK , May 2, 2016 Leading Economies ... Growth Ethiopia 10.2 Côte d,Ivoire 8.6 Uzbekistan 8 Ireland 7.8 India 7.3, ... TechSci Research, BRICS nations , which comprises of Brazil ... China and South Africa , registered the fastest ... economic slowdown in China , recession in Brazil ...
Breaking Medicine Technology: