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Increased glucose level is a strong risk factor for colorectal cancer
Date:11/1/2007

the cut point for the patients in the high group in the study; a fasting blood glucose level between 100 and 125 mg/dl signals pre-diabetes. The levels used in the study are reflective of those in the general U.S. population, therefore it is important to note that even a modest elevation of fasting glucose can affect a patients risk of colorectal cancer.

Patients who presented with the highest levels of both insulin and glucose had an approximately 50 percent increased risk of colorectal tumor recurrence. The Polyp Prevention Trial found a recurrence for colorectal tumors of 39.6 percent over four years, meaning the recurrence rate in this subset of patients represents a large increase in absolute risk. Patients who had a high concentration of glucose experienced more than 2.4 times increased odds of advanced tumor recurrence. The subjects with the highest glucose concentration also tended to be slightly older and have higher body mass index (BMI) and waist to hip ratios. Additionally, they were more likely to be male, current smokers, a member of a minority group and less likely to have advanced beyond a high school education. For those without a family history of colorectal cancer, researchers observed an even greater risk with elevated concentrations of insulin and glucose compared to the overall study population.

More than 1,905 patients from the Polyp Prevention Trial completed the study protocol, of which 375 matched pairs, or 750 patients, were included in this subset analysis. The patients were matched for gender and age within five years among trial participants who had recurrent adenomas and stored serum. The Polyp Prevention Trial was a clinical trial headed by the National Cancer Institute conducted with 2,079 men and women to determine the effect of a low-fat, high-fiber, high fruit/vegetable eating plan on the recurrence of precancerous polyps in the colon and rectum. Every participant had been diagnosed with a polyp within the pre
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Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

Page: 1 2 3

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