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Increased cancer risk following the use of radioactive Radium-224 in the therapy
Date:6/23/2008

ely to 224Radium preparations being declared obsolete and have resulted in the revocation of the licensing of SpondylAT by the Federal Institute for Drugs and Medical Devices (BfArM) and the decision by the licence holders to discontinue development of the treatment. In earlier legal proceedings the Cologne Administrative Court, in its decision of October 26th, 2006, came to the conclusion that the "increase of myeloid leukaemia [] could be explained causally with the deposition of radium as a calcium-like element into the bone", because, due to its short half-life of only 3.66 days, the radiation released from 224Radium has its effect mainly at the bone surface in the proximity of the blood-forming bone marrow cells.

Although previous studies have shown that radium treatment has an analgesic effect the risks of 224Radium treatment exceed its benefit, particularly, since there are many other therapeutic options available. Accordingly, the Committee for Quality Assurance of the German Society for Rheumatology no longer include this therapy in its recommendations.


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Contact: Dr. Roland R. Wick
wick@helmholtz-muenchen.de
49-893-187-2518
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

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