Navigation Links
Incorrect Cell Lines Used for Worldwide Cancer Research
Date:1/14/2010

But tumor-type mixups don't necessarily negate findings, experts say

THURSDAY, Jan. 14 (HealthDay News) -- Cancer researchers rely on specific tumor cell lines when developing new treatments, but those samples aren't always what they're advertised to be, a Dutch team reports.

Their study found that three of 13 human esophageal cancer cell lines widely used for worldwide research were actually cell lines from lung, colorectal and other malignancies.

Two of the contaminated or misidentified cell lines were involved in research published in more than 100 papers and in the issuance of 11 U.S. patents, which led to clinical trials in patients.

One of those trials involved testing the drug Nexavar (sorafenib) on patients with Barrett-related esophageal adenocarcinoma. Nexavar is approved for kidney and liver cancer but not yet for this indication.

While earlier-phase studies using these cell lines are still "scientifically sound," the clinical trials should be revisited, said Winand N.M. Dinjens, senior author of a short paper published online Jan. 14 in the Journal of the National Cancer Institute and head of molecular diagnostics in the department of pathology at the Josephine Nefkens Institute, University Medical Center Rotterdam in The Netherlands.

"Widespread use of contaminated cell lines threatens the development of treatment strategies for EAC," he and his colleagues wrote.

Other experts expressed less concern, saying the unintentional misidentification or contamination of the cell lines is not critical and is even a fairly common occurrence.

"From the scientific point of view, it's not a huge deal, but it's certainly something you're glad you found out," said Charles Saxe, scientific director of the Program in Cancer Cell Biology and Metastasis at the American Cancer Society in Atlanta. "This probably doesn't surprise anybody. The surprise is probably that there w
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Consumer Group Responds to Governor Schwarzeneggers Incorrect Claims About the Impact of Medical Malpractice Caps
2. Out of court settlement of malpractice claims: Incorrect treatment of bone fractures in children
3. Physician Hospitals (PHA) Responds to TIME Magazine Article: Filled With Incorrect Assumption and Innuendo
4. Many Baby Boomers Incorrectly Believe They Are Protected Against the Risk of Disability
5. Neuralstem Responds to Incorrect StemCells, Inc. Release on Patents
6. Get Vaccinated Against a Second Wave of H1N1 Flu for Only $15 And no Waiting in Long Lines
7. Allsup Outlines What You Need to Know Before Filing Your SSDI Claim
8. Fewer headaches on the horizon thanks to latest guidelines
9. Physician Satisfaction with Electronic Medical Records Declines
10. New Guidelines Urge A1C Test for Diabetes Diagnosis
11. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Demand Response Management Systems is a crucial peak ... imbalance between energy supply and demand. With the help ... (due to increasing pressure on the grid) and replaced ... residential appliances and thermostats for load reduction. , ... and with government mandates and benefits for energy efficiency ...
(Date:7/12/2014)... 12, 2014 Tylenol lawsuits ( ... move forward in the federal multidistrict litigation underway ... Bernstein Liebhard LLP reports. According to a filing ... F. Stengel has ordered the deposition of a ... found that the witness’s testimony concerning the marketing ...
(Date:7/12/2014)... (HealthDay News) -- Burn injuries increase in the summer as ... burn experts. Among those most vulnerable to these seasonal fire ... and often get burned by putting their hands on the ... the burn unit at Loyola University Medical Center in Maywood, ... adage of ,When you play with fire, you get burned, ...
(Date:7/12/2014)... July 12, 2014 “After my mom’s stroke, she ... a stroke and loss the use of his left side. Eating ... a way to help people like them enjoy eating again,” said ... prototype for the PATRICIA CAROL HALL PLATE (P C H PLATE). ... a more ergonomic way to eat for individuals who suffer from ...
(Date:7/12/2014)... July 12, 2014 With prom shopping ... manufacturer and retailer, is ready to showcase its new ... new collection of evening dresses in its online shop. ... 67% off) for these elegant gowns. According to the ... end on July 26, 2014. , He says, ...
Breaking Medicine News(10 mins):Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:Burn Injuries More Common in Summer 2Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2
... clinical trial of the experimental drug dimebon (latrepirdine) in people ... cognition. That is the conclusion of a study published ... "This is the first clinical trial that has focused ... disease," said University of Rochester Medical Center neurologist Karl Kieburtz, ...
... with use, but other factors may contribute, experts say , ... treat glaucoma appear to outlive those who don,t treat the ... reduced risk for premature death stems from the glaucoma drugs ... access to health care remains unclear. , Use of glaucoma ...
... residue may give rise to new pollutants indoors, chemists ... smoke residue found on indoor surfaces -- so-called "third-hand ... new, potentially cancer-causing substances, research suggests. , Details about ... what health concerns it might create remain unclear, however, ...
... BOSTON , Feb. 8 The National Patient ... on March 7, 2010 , in a concerted effort ... of health care, and strengthen alliances between patients, families and ... During the week, participating hospitals and healthcare systems will plan ...
... , Feb. 8 Independence Blue Cross (IBC) today ... newly created role of senior vice president of marketing services. He ... executive, Linda M. Taylor . , In this new ... care consumers better manage their care and will also head product ...
... , Feb. 8 SpectraCell Laboratories announced that ... D.C. to its scientific staff as Director of Clinical Nutrition ... national basis and consult with clients on the implementation of ... is a long-time client of SpectraCell, using their micronutrient testing ...
Cached Medicine News:Health News:Drug shows promise for Huntington's disease 2Health News:Glaucoma Drugs May Play Role in Longer Life 2Health News:Glaucoma Drugs May Play Role in Longer Life 3Health News:'Third-Hand Smoke' Could Be Troublesome, Too 2Health News:'Third-Hand Smoke' Could Be Troublesome, Too 3Health News:National Patient Safety Foundation Leads Nationwide Effort to Promote Patient Safety 2Health News:Independence Blue Cross Names John Janney to Newly Created Position: Senior Vice President Marketing Services 2Health News:Independence Blue Cross Names John Janney to Newly Created Position: Senior Vice President Marketing Services 3Health News:Dr. Ron Grabowski Named Director of Clinical Nutrition and Education for SpectraCell Laboratories 2Health News:Dr. Ron Grabowski Named Director of Clinical Nutrition and Education for SpectraCell Laboratories 3
(Date:7/10/2014)... Quebec , July 10, 2014  Valeant Pharmaceuticals ... VRX) today announced it has completed the sale to ... and Dysport owned or held by Valeant for $1.4 ... with Nestle S.A, which recently completed its acquisition of ... the divestiture of our products to a company that ...
(Date:7/10/2014)... July 10, 2014 CVS Caremark Corporation (NYSE: ... has approved a quarterly dividend of $0.275 (27.5 cents) per ... on August 1, 2014, to holders of record on July ... CVS Caremark is dedicated to helping people on their path ... the United States . Through the company,s ...
(Date:1/15/2014)... ANTONIO , Jan. 15, 2014 Most osteoporosis ... according to a recent online survey* sponsored by Mission ... among the National Osteoporosis Foundation online support community, revealed ... take medication that comes in a form other than ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3
InterVascular HemaPatch product line offers the vascular surgeon a range of collagen coated patches in a range of larger sizes angioplasty, or profundaplasty procedures without suture hole bleeding. ...
The VasoSeal Low Profile device is designed for smaller sheath angiography procedures. VasoSeal Low Profile. Seal your arterial punctures with confidence....
D-Stat Radial is a dry version of the D-Stat together with a compression band, and is designed for the control of surface bleeding from vascular access sites, including the sites on the radial artery...
The D-Stat Radial hemostat band utilizes a compression band together with the active haemostatic material of the D-Stat to control surface bleeding....
Medicine Products: