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InDevR's FluChip detects and distinguishes swine-origin H1N1 from human influenza viruses
Date:5/5/2009

InDevR, a small biotech company in Boulder, CO, and the Influenza Division of the Centers for Disease Control and Prevention (CDC) in Atlanta confirmed today that the M gene version of InDevR's FluChip can detect swine-origin H1N1 influenza A viruses and clearly distinguish them from seasonal influenza viruses (A/H1N1 and A/H3N2) as well as the deadly avian A/H5N1 virus.

The FluChip was invented by a joint team of scientists at the University of Colorado at Boulder and the Centers for Disease Control and Prevention in an NIAID-supported effort led by then-Professor Kathy Rowlen, CEO of InDevR. InDevR recently licensed the intellectual property from the University of Colorado and CDC.

The CDC provided InDevR scientists with non-infectious genetic material from swine-origin influenza viruses earlier this week. The FluChip performance was evaluated with several of these samples in a side-by-side comparison with seasonal human influenza viruses. "The FluChip assay detected all of the 6 swine-origin H1N1 viruses tested, and the resulting pattern, or signature, on the microarray was dramatically different than the signature for seasonal A/H1N1 and A/H3N2 viruses. Interestingly, the signature of the swine H1N1 virus indicated an avian component within the M-gene, which is consistent with its reported Eurasian lineage, said Dr. Erica Dawson, the Lead Scientist on the project at InDevR and co-inventor of the FluChip technology. Representative results from this study are available on the InDevR website (www.indevr.com/FluChip.htm).

The FluChip is expected to be a powerful addition to the influenza surveillance toolkit since it will be less susceptible to failure than qRT-PCR assays as the virus continues to evolve. According to Rowlen the reason that the M-gene version of the FluChip is more robust has to do with the fact that the diagnostic target is a stable, internal gene which codes for the virus' matrix proteins. Current qRT-PCR sub
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Contact: Kathr rowlen
Rowlen@indevr.com
303-402-9100
University of Colorado at Boulder
Source:Eurekalert

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